Results 51 to 60 of about 34,742 (282)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Real-time artificial intelligence-assisted detection and segmentation of nasopharyngeal carcinoma using multimodal endoscopic data: a multi-center, prospective studyResearch in context

EClinicalMedicine
Summary: Background: Nasopharyngeal carcinoma (NPC) is a common malignancy in southern China, and often underdiagnosed due to reliance on physician expertise.
Rui He, Pengyu Jie, Weijian Hou, Yudong Long, Guanqun Zhou, Shumei Wu, Wanquan Liu, Wenbin Lei, Weiping Wen, Yihui Wen   +9 more
doaj   +1 more source

Motor function outcomes of pediatric patients with hemiplegic cerebral palsy after rehabilitation treatment: a diffusion tensor imaging study

Neural Regeneration Research, 2015
Previous diffusion tensor imaging (DTI) studies regarding pediatric patients with motor dysfunction have confirmed the correlation between DTI parameters of the injured corticospinal tract and the severity of motor dysfunction.
Jin Hyun Kim, Yong Min Kwon, Su Min Son
doaj   +1 more source

Necessary and sufficient conditions for local creation of quantum correlation

, 2012
Quantum correlation can be created by a local operation from some initially classical states. We prove that the necessary and sufficient condition for a local trace-preserving channel to create quantum correlation is that it is not a commutativity ...
Fan, Heng, Hu, Xueyuan, Liu, Wu-Ming, Zhou, D. L.   +3 more
core   +1 more source

Inefficient Star Formation In Extremely Metal Poor Galaxies [PDF]

, 2014
The first galaxies contain stars born out of gas with little or no metals. The lack of metals is expected to inhibit efficient gas cooling and star formation but this effect has yet to be observed in galaxies with oxygen abundance relative to hydrogen ...
Armus, Lee, Gao, Yu, Gu, Qiusheng, Helou, George, Shi, Yong, Stierwalt, Sabrina, Wang, Junzhi, Zhang, Zhi-Yu   +7 more
core   +2 more sources

A review for grant application and merit review in the field of synthetic chemistry of NSFC from 2018 to 2020 [PDF]

SCIENTIA SINICA Chimica, 2021
Chunju Li, Wei Tian, Shaodong Zhang, Qiang Kang, Xuefeng Fu   +4 more
openaire   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Short-term use of antiepileptic drugs is neurotoxic to the immature brain

Neural Regeneration Research, 2015
Previous studies have shown that the long-term use of antiepileptic drugs can cause nervous system damage. However, short-term antiepileptic drug treatment is frequently given to infants, especially neonates, to control seizure.
Yu Liu, Xue-ying Wang, Dan Li, Lin Yang, Shao-ping Huang   +4 more
doaj   +1 more source

On the Convergence of the Self-Consistent Field Iteration in Kohn-Sham Density Functional Theory

, 2013
It is well known that the self-consistent field (SCF) iteration for solving the Kohn-Sham (KS) equation often fails to converge, yet there is no clear explanation.
Liu, Xin, Wang, Xiao, Wen, Zaiwen, Yuan, Yaxiang   +3 more
core   +1 more source

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source