Use of q-values to Improve a Genetic Algorithm to Identify Robust Gene Signatures [PDF]
Several approaches have been proposed for the analysis of DNA microarray datasets, focusing on the performance and robustness of the final feature subsets.
Chambers, SJ +5 more
core +1 more source
A CLIP on the Ear: Spitz Melanocytoma Harbouring a CLIP2-BRAF Gene Fusion
Case Reports in Dermatological Medicine, Volume 2026, Issue 1, 2026.Spitzoid lesions represent one of the most challenging areas in melanocytic pathology. Many such lesions are characterised by key gene alterations including ALK, ROS and NTRK fusions. BRAF mutations are generally considered incompatible with the diagnosis of Spitz tumours. Here, we present the case of a spitzoid melanocytoma harbouring a rare BRAF gene
Karwan A. Moutasim +3 more
wiley +1 more source
Single-Cell RNA-seq Reveals Profound Alterations in Mechanosensitive Dorsal Root Ganglion Neurons with Vitamin E Deficiency. [PDF]
, 2019 Ninety percent of Americans consume less than the estimated average requirements of dietary vitamin E (vitE). Severe vitE deficiency due to genetic mutations in the tocopherol transfer protein (TTPA) in humans results in ataxia with vitE deficiency (AVED)
Bordbari, Matthew H +9 more
core
Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington's Disease. [PDF]
, 2018 Huntington's disease (HD) patients suffer from a progressive neurodegeneration that results in cognitive, psychiatric, cardiovascular, and motor dysfunction.
Colwell, Christopher S +5 more
core +1 more source
Congenital Insensitivity to Pain with Anhidrosis in an Iranian Patient
Basic and Clinical Neuroscience, 2013 Congenital insensitivity to pain with anhidrosis is a rare disease of the nervous system which causes one to lose his/her feeling of pain. The disease is subtype four of hereditary sensory and autonomic neuropathy (HSAN IV) that results from NTRK1 gene ...
Nasrollah Saleh-gohari +1 more
doaj +2 more sources
Frontiers in Microbiology, 2018 Ebolavirus (EBOV) life cycle involves interactions with numerous host factors, but it remains poorly understood, as does pathogenesis. Herein, we synthesized 65 siRNAs targeting host genes mostly connected with aspects of the negative-sense RNA virus ...
Dong-Shan Yu +17 more
doaj +1 more source
BMC Cancer, 2019 Background Pulmonary sarcomatoid carcinoma (SC) consists of both carcinomatous and sarcomatous tumors with high degree of malignancy, rapid progression, and poor prognosis. However, little is known regarding how pulmonary SC develops and progresses. Case
Jianjun Ge +7 more
doaj +1 more source
Decreased Pain Severity and Differential Gene Expression Following Calmare Therapy [PDF]
, 2015 We present the results of a double-blinded randomized sham-controlled research study of a non-pharmacologic low back pain intervention. Calmare therapy is an neurocutanous electrical stimulation approach for pain management.
Heineman, Amy +2 more
core +1 more source
A Novel Oncogenic and Drug-Sensitive KIF5B-NTRK1 Fusion in Lung Adenocarcinoma
Current OncologyWe present a case of a lung adenocarcinoma patient harboring a novel kinesin family member 5B (KIF5B)-NTRK1 gene fusion that responds well to entrectinib.
Hui Li +6 more
doaj +1 more source
Prevalence of established and emerging biomarkers of immune checkpoint inhibitor response in advanced hepatocellular carcinoma. [PDF]
, 2019 The clinical deployment of immune checkpoint inhibitors (ICIs) has created a tandem drive for the identification of biomarkers linked to benefit. Comprehensive genomic profiling was performed to evaluate the frequency of genomic biomarkers of ICI ...
Ali, Siraj M +10 more
core +1 more source