The role of clathrin in post-golgi trafficking in toxoplasma gondii [PDF]
, 2013 Apicomplexan parasites are single eukaryotic cells with a highly polarised secretory system that contains unique secretory organelles (micronemes and rhoptries) that are required for host cell invasion.
Ferguson, D.J.P. +3 more
core +18 more sources
The Knowns and Unknowns of Herpesvirus Nuclear Egress
Annual Review of Virology, 2023 Nuclear egress of herpesvirus capsids across the intact nuclear envelope is an exceptional vesicle-mediated nucleocytoplasmic translocation resulting in the delivery of herpesvirus capsids into the cytosol. Budding of the (nucleo)capsid at and scission from the inner nuclear membrane (INM) is mediated by the viral nuclear egress complex (NEC) resulting
Barbara G, Klupp, Thomas C, Mettenleiter
openaire +2 more sources
The Herpes Simplex Virus Protein pUL31 Escorts Nucleocapsids to Sites of Nuclear Egress, a Process Coordinated by Its N-Terminal Domain. [PDF]
PLoS Pathogens, 2015 Progeny capsids of herpesviruses leave the nucleus by budding through the nuclear envelope. Two viral proteins, the membrane protein pUL34 and the nucleo-phosphoprotein pUL31 form the nuclear egress complex that is required for capsid egress out of the ...
Christina Funk +7 more
doaj +1 more source
Exit of Plasmodium Sporozoites from Oocysts Is an Active Process That Involves the Circumsporozoite Protein [PDF]
, 2005 Plasmodium sporozoites develop within oocysts residing in the mosquito midgut. Mature sporozoites exit the oocysts, enter the hemolymph, and invade the salivary glands.
Fujioka, Hisashi +2 more
core +7 more sources
Critical Steps of Plasmodium falciparum Ookinete Maturation [PDF]
, 2020 The egress and fertilization of Plasmodium gametes and development of a motile ookinete are the first crucial steps that mediate the successful transmission of the malaria parasites from humans to the Anopheles vector. However, limited information exists
Alano, P. +5 more
core +1 more source
Baculovirus Actin-Based Motility Drives Nuclear Envelope Disruption and Nuclear Egress [PDF]
Current Biology, 2018 Viruses that replicate in the host cell nucleus face challenges in usurping cellular pathways to enable passage through the nuclear envelope [1]. Baculoviruses are enveloped, double-stranded DNA viruses that infect lepidopteran insects and are tools for protein expression, cell transduction, and pest management [2-4].
Ohkawa, Taro, Welch, Matthew D
openaire +4 more sources
Nuclear envelope budding and its cellular functions
Nucleus, 2023 The nuclear pore complex (NPC) has long been assumed to be the sole route across the nuclear envelope, and under normal homeostatic conditions it is indeed the main mechanism of nucleo-cytoplasmic transport.
Katharina S. Keuenhof +6 more
doaj +1 more source
Human Cytomegalovirus pUL93 Links Nucleocapsid Maturation and Nuclear Egress [PDF]
Journal of Virology, 2016 ABSTRACT Human cytomegalovirus (HCMV) pUL93 and pUL77 are both essential for virus growth, but their functions in the virus life cycle remain mostly unresolved. Homologs of pUL93 and pUL77 in herpes simplex virus 1 (HSV-1) and pseudorabies virus (PRV) are known to interact to form a complex at capsid vertices known as the capsid vertex ...
Bernadette M, DeRussy +2 more
openaire +2 more sources
NECing goes: flexibility of the herpesvirus nuclear egress complex
, 2023 AbstractThe nuclear egress complex (NEC) allows herpesvirus capsids to escape from the nucleus without breaking the nuclear envelope barrier. It assembles into a lattice on the inner nuclear membrane enveloping newly assembled nucleocapsids, which bud into the perinuclear space.
Pražák V +12 more
europepmc +2 more sources
Defining stage-specific activity of potent new inhibitors of Cryptosporidium parvum growth in vitro [PDF]
, 2020 Currently, nitazoxanide is the only FDA-approved treatment for cryptosporidiosis; unfortunately, it is ineffective in immunocompromised patients, has varied efficacy in immunocompetent individuals, and is not approved in infants under 1 year of age ...
Funkhouser-Jones, Lisa J +2 more
core +2 more sources