Results 181 to 190 of about 10,967 (201)

Targeting SARS-CoV-2 Structural and Accessory Proteins: Emerging Opportunities for Small-Molecule Coronavirus Antivirals. [PDF]

Pharmaceutics
Porta EOJ, AlKharboush DF, Jackson L, Pang F, Darin A, Louka J, Shi X, Wells G, Kozielski F.   +8 more
europepmc   +1 more source

Targeting protein-protein interactions in Plasmodium: from asexual replication to sexual development. [PDF]

Parasit Vectors
Tang J, Tang W, Xie Y, Yang W, Luo X, Yu Y, He B, Liu C, Li Z.   +8 more
europepmc   +1 more source

Applying 3D correlative structured illumination microscopy and X-ray tomography to characterise herpes simplex virus-1 morphogenesis. [PDF]

Elife
Nahas KL, Connor V, Wijesinghe KJ, Barrow HG, Dobbie IM, Harkiolaki M, Graham SC, Crump CM.   +7 more
europepmc   +1 more source

Protein kinases responsible for the phosphorylation of the nuclear egress core complex of human cytomegalovirus

Journal of General Virology, 2017
Nuclear egress of herpesvirus capsids is mediated by a multi-component nuclear egress complex (NEC) assembled by a heterodimer of two essential viral core egress proteins. In the case of human cytomegalovirus (HCMV), this core NEC is defined by the interaction between the membrane-anchored pUL50 and its nuclear cofactor, pUL53.
Anne-Marie Hesse, Manfred Marschall, Uwe Sonnewald   +2 more
exaly   +4 more sources

Some of the next articles are maybe not open access.

Related searches:

An antiviral targeting strategy based on the inducible interference with cytomegalovirus nuclear egress complex

Antiviral Research, 2023
The nucleocytoplasmic capsid egress of herpesviruses like the human cytomegalovirus (HCMV) is based on a uniquely regulated process. The core nuclear egress complex (NEC) of HCMV, represented by the pUL50-pUL53 heterodimer, is able to oligomerize and thus to build hexameric lattices.
Jintawee Kicuntod, Sigrun Häge, Josephine Lösing, Serli Kopar, Yves A. Muller, Manfred Marschall   +5 more
openaire   +2 more sources

The human cytomegalovirus nuclear egress complex unites multiple functions: Recruitment of effectors, nuclear envelope rearrangement, and docking to nuclear capsids

Reviews in Medical Virology, 2017
SummaryBackgroundNuclear replication represents a common hallmark of herpesviruses achieved by a number of sequentially unrolled regulatory processes. A rate‐limiting step is provided by nucleo‐cytoplasmic capsid export, for which a defined multiregulatory protein complex, namely, the nuclear egress complex (NEC), is assembled comprising both viral and
Heinrich Sticht, Manfred Marschall, Yves A Müller   +2 more
exaly   +3 more sources

Analysis of the nuclear egress complex of mouse cytomegalovirus

2007
Herpesvirus infections are usually asymptomatic or associated with mild symptoms. Fatal diseases are seen in immune suppressed and immune incompetent individuals. Although herpesviruses are of emerging medical importance nowadays an infection only can be controlled by chemotherapeutics, which target viral DNA replication and cause negative side effects.
openaire   +1 more source

Reconstitution of the herpesviral pUL31-pUL34 nuclear egress complex function

2015
Um sich in einer Vielzahl von Wirten vermehren zu können, haben sich Herpesviren im Laufe ihrer Evolution erfolgreich angepasst. Sie sind die bisher einzig bekannten Viren, die nach einer Erstinfektion ein Leben lang in ihrem Wirtsorganismus persistieren, indem sie in eine Art Ruhezustand (Latenz) übergehen.
openaire   +4 more sources

The conserved core nuclear egress complex (NEC) as an antiherpesviral drug target: Pharmacophore-based identification of NEC-specific inhibitors

Antiviral Research
The nucleocytoplasmic capsid egress of herpesviruses is a uniquely regulated process. As well-established for the human cytomegalovirus (HCMV) core nuclear egress complex (NEC), the pUL50-pUL53 NEC heterodimer oligomerizes and builds hexameric lattices for the regulated nucleocytoplasmic release of viral capsids.
Julia Tillmanns, Verena Battisti, Jintawee Kicuntod, Friedrich Hahn, Debora Obergfäll, Pia Geiger, Sabrina Wagner, Helmut Buschmann, Bernhard Lesch, Peter Lischka, Heinrich Sticht, Thierry Langer, Manfred Marschall   +12 more
openaire   +2 more sources

The cytomegalovirus nuclear egress complex: compositional and functional characterization leading to an antiviral targeting

2023
The nuclear egress is an essential stage during lytic replication of human cytomegalovirus (HCMV) that regulates the nucleocytoplasmic translocation of viral capsids. The core nuclear egress complex (NEC) consists of two conserved viral proteins, pUL50 and pUL53, and acts as a mediator in the recruitment of a number of NEC-associated viral and cellular
openaire   +1 more source