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Computational Analysis of Herpesviral Nuclear Egress Complexes and the Hapten Binding Antibody B1-8

2019
Proteins have a large impact on how pathogens interact with their host and vice versa. On the pathogen side, this work investigates the nuclear egress complex (NEC) of her pesviruses, which can reshape the inner nuclear membrane (INM) of the host cells and is vital for viral proliferation.
openaire   +1 more source

Characterization of a viral-cellular protein complex which controls the nuclear egress of human cytomegalovirus

2010
Human cytomegalovirus (HCMV) has developed a replication strategy that is well adapted to conditions of the host cell. Notably, after nuclear capsid assembly, HCMV capsids traverse the nuclear envelope for nuclear egress. In this regard, the phosphorylation-mediated disassembly of the nuclear lamina is believed to be a prerequisite for the budding of ...
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Function of the Nonconserved N-Terminal Domain of Pseudorabies Virus pUL31 in Nuclear Egress

Journal of Virology, 2018
Walter Fuchs   +2 more
exaly  

Studies on two essential viral proteins forming the core nuclear egress complex of human cytomegalovirus

2014
Human cytomegalovirus (HCMV) is characterized by nuclear replication including synthesis of viral DNA and intranuclear formation of capsids. The nucleocytoplasmic export of cytomegaloviral capsids is regulated by formation of a multicomponent nuclear egress complex (NEC) consisting of viral and cellular proteins and essentially based on the viral NEC ...
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Novel Mode of Phosphorylation-triggered Reorganization of the Nuclear Lamina during Nuclear Egress of Human Cytomegalovirus

Journal of Biological Chemistry, 2010
Heinrich Sticht   +2 more
exaly  

Faculty Opinions recommendation of Membrane deformation and scission by the HSV-1 nuclear egress complex.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2014
openaire   +1 more source

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