Results 61 to 70 of about 26,611 (238)

Energy- and temperature-dependent transport of integral proteins to the inner nuclear membrane via the nuclear pore [PDF]

, 2004
Resident integral proteins of the inner nuclear membrane (INM) are synthesized as membrane-integrated proteins on the peripheral endoplasmic reticulum (ER) and are transported to the INM throughout interphase using an unknown trafficking mechanism.
Gerace, Larry, Nishimoto, Takeharu, Ohba, Tomoyuki, Schirmer, Eric C   +3 more
core   +3 more sources

Biochemical, Biophysical, and Mutational Analyses of Subunit Interactions of the Human Cytomegalovirus Nuclear Egress Complex [PDF]

Journal of Virology, 2009
ABSTRACT Nuclear egress, the trafficking of herpesvirus nucleocapsids from the nucleus to the cytoplasm, involves two conserved viral proteins that form a complex at the nuclear envelope, referred to as the nuclear egress complex. In human cytomegalovirus, these two proteins are called UL50 and UL53. To study UL50 and UL53 in molecular detail,
Sam, My, Evans, Brady, Coen, Donald, Hogle, James   +3 more
openaire   +3 more sources

The Oligomeric Assemblies of Cytomegalovirus Core Nuclear Egress Proteins Are Associated with Host Kinases and Show Sensitivity to Antiviral Kinase Inhibitors

Viruses, 2022
The nucleo-cytoplasmic capsid egress of herpesviruses is a unique regulated process that ensures the efficiency of viral replication and release. For human cytomegalovirus (HCMV), the core of the nuclear egress complex (NEC) consists of the pUL50–pUL53 ...
Jintawee Kicuntod, Sigrun Häge, Friedrich Hahn, Heinrich Sticht, Manfred Marschall   +4 more
doaj   +1 more source

Structure of the herpes-simplex virus portal-vertex [PDF]

, 2018
Herpesviruses include many important human pathogens such as herpes simplex virus, cytomegalovirus, varicella-zoster virus, and the oncogenic Epstein–Barr virus and Kaposi sarcoma–associated herpesvirus.
Bhella, David, McElwee, Marion, Rixon, Frazer, Vijayakrishnan, Swetha   +3 more
core   +2 more sources

Inhibition of Human Cytomegalovirus Particle Maturation by Activation of Liver X Receptor

Frontiers in Microbiology, 2022
Human cytomegalovirus (HCMV), a herpesvirus family member, is a large, complex enveloped virus. The activation of liver X receptor (LXR) can significantly inhibit the replication of HCMV and weaken the virulence of progeny virus (unpublished data).
Bingnan Liu, Bingnan Liu, Bingnan Liu, Yanping Ma, Yanping Ma, Yanping Ma, Yujing Huang, Yujing Huang, Yujing Huang, Zhongyang Liu, Zhongyang Liu, Zhongyang Liu, Qiang Ruan, Qiang Ruan, Qiang Ruan, Ying Qi, Ying Qi, Ying Qi   +17 more
doaj   +1 more source

Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human Vam6p from the cytoplasm to the nucleus [PDF]

, 2011
Merkel cell polyomavirus (MCV) has been recently described as the cause for most human Merkel cell carcinomas. MCV is similar to simian virus 40 (SV40) and encodes a nuclear large T (LT) oncoprotein that is usually mutated to eliminate viral replication ...
Ali, Binda, Campbell, Campbell, Caplan, Cotsiki, Côté-Martin, DeCaprio, Dilworth, Felici, Feng, Flinn, Hakki, Houben, Jennifer Hein, Lane, Laude, Li, Liang, Linzer, Mannová, Nakamura, Nakamura, Ole V. Gjoerup, Pallas, Patrick S. Moore, Pelkmans, Per H. Basse, Peralta, Pipas, Poupon, Price, Qian, Richardson, Schowalter, Shuda, Shuda, Simon C.W. Richardson, Srinivasan, Sukarieh, Tuna Toptan, Whitman, Wrana, Wurmser, Xi Liu, Yuan Chang   +45 more
core   +2 more sources

Transit Lightcurve Signatures of Artificial Objects [PDF]

, 2005
The forthcoming space missions, able to detect Earth-like planets by the transit method, will a fortiori also be able to detect the transit of artificial planet-size objects.
Luc F. A. Arnold, Tarter J.
core   +3 more sources

Cytomegaloviral proteins that associate with the nuclear lamina: components of a postulated nuclear egress complex

Journal of General Virology, 2009
The nuclear egress of cytomegaloviral capsids traversing the nuclear envelope is dependent on a locally restricted destabilization of the rigid nuclear lamina. It has been suggested that the multi-component nuclear egress complex (NEC) that is formed is comprised of both viral and cellular proteins which act to recruit lamin-phosphorylating protein ...
Jens, Milbradt, Sabrina, Auerochs, Heinrich, Sticht, Manfred, Marschall   +3 more
openaire   +2 more sources

HVint: a strategy for identifying novel protein-protein interactions in Herpes Simplex Virus Type 1 [PDF]

, 2016
Human herpesviruses are widespread human pathogens with a remarkable impact on worldwide public health. Despite intense decades of research, the molecular details in many aspects of their function remain to be fully characterized.
Albright, Antinone, Aranda, Bastian, Berman, Blohm, Booy, Brady, Brückner, Budayeva, Calderone, Calderwood, Cardone, Chabaud, Chabaud, Chatr-Aryamontri, Chen, Chen, Chentoufi, Chowdary, Coller, Conner, Connolly, Cristea, Dai, Dai, Daikoku, de Chassey, de Oliveira, DeBlasio, Deng, Desai, Desai, Desai, Deutsch, Douglas, Dufour, Durmuş Tekir, Döhner, Eisenberg, Engel, Folador, Fossum, Funk, Greco, Grünenfelder, Grünewald, Guirimand, Guo, Hagen, Hosur, Hosur, Jaeger, Kerrien, Klupp, Kobayashi, Kopp, Kopp, Kramer, Krautwald, Kshirsagar, Kulak, Langelier, Lawson, Lee, Leege, Lenk, Lin, Loomis, Loret, Lyman, López-Blanco, Lövheim, Marcoux, Marras, McDowall, Meckes, Mora, Murakami, Nagel, Nagel, Navlakha, Nourani, Nozawa, Orchard, Panagiotidis, Radtke, Ramisetty, Remmert, Reynolds, Rollenhagen, Roller, Roller, Rowles, Rozen, Saeed, Schnee, Sheaffer, Silva, Singh, Snijder, Snyder, Sprinzak, Stampfer, Stellberger, Stelzl, Sugimoto, Suzek, Szklarczyk, Taylor, The UniProt Consortium, Thomsen, To, Tomishima, Toropova, Trus, Trus, Uetz, Uetz, Villaveces, Vittone, Vizcaíno, Wills, Winterbach, Wnuk, Xenarios, Yang, Yeh, You, Yu, Zahiri, Zeev-Ben-Mordehai, Zhang, Zhou   +133 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source