Results 51 to 60 of about 26,575 (247)

A physical link between the pseudorabies virus capsid and the nuclear egress complex. [PDF]

J Virol, 2011
ABSTRACT Following their assembly, herpesvirus capsids exit the nucleus by budding at the inner nuclear membrane. Two highly conserved viral proteins are required for this process, pUL31 and pUL34. In this report, we demonstrate that the pUL31 component of the pseudorabies virus nuclear egress complex is a conditional capsid-binding protein ...
Leelawong M, Guo D, Smith GA.
europepmc   +4 more sources

XMM-Newton X-ray spectroscopy of the high-mass X-ray binary 4U1700-37 at low flux [PDF]

, 2004
We present results of a monitoring campaign of the high-mass X-ray binary system 4U 1700-37/HD 153919, carried out with XMM-Newton in February 2001. The system was observed at four orbital phase intervals, covering 37% of one 3.41-day orbit.
A. van der Meer, Ankay, Ballet, Barziv, Bautista, Blondin, Boroson, Boroson, Brown, Burderi, Clark, den Herder, Drake, Dupree, Ebisawa, Goldstein, Gottwald, Haberl, Haberl, Haberl, Haberl, Hatchett, Hayakawa, Heap, Hickox, Hutchings, in 't Zand, Jansen, Johnson, Jones, Kaastra, Kaper, Kaper, Kaper, Kaper, Kilian, L. Kaper, La Barbera, Liu, Lotz, M. Méndez, M. van der Klis, Mason, Morrison, N. R. Trams, Nagase, Nagase, P. Barr, Paerels, Quaintrell, Reynolds, Rubin, Sako, Schaller, Schulz, Strüder, T. Di Salvo, Tarter, Trümper, Turner, van Loon, Vink, Vink, Watanabe, White, Wojdowski   +65 more
core   +2 more sources

Toxoplasma gondii Syntaxin 6 is required for vesicular transport between endosomal-like compartments and the Golgi Complex [PDF]

, 2013
Apicomplexans are obligate intracellular parasites that invade the host cell in an active process that relies on unique secretory organelles (micronemes, rhoptries and dense granules) localized at the apical tip of these highly polarized eukaryotes ...
Clucas, Caroline, Ferguson, David J., Jackson, Allison J., Mamczur, Nicola J., Meissner, Markus   +4 more
core   +1 more source

Neural regulation of cancer: from mechanobiology to inflammation. [PDF]

, 2016
Despite recent progress in cancer research, the exact nature of malignant transformation and its progression is still not fully understood. Particularly metastasis, which accounts for most cancer death, is a very complex process, and new treatment ...
Kim, Tae-Hyung, Rowat, Amy C, Sloan, Erica K   +2 more
core   +2 more sources

Equine herpesvirus 1 bridles T lymphocytes to reach its target organs [PDF]

, 2019
Equine herpesvirus 1 (EHV1) replicates in the respiratory epithelium and disseminates through the body via a cell-associated viremia in leukocytes, despite the presence of neutralizing antibodies. "Hijacked" leukocytes, previously identified as monocytic
Azab, Walid, Couck, Liesbeth, Favoreel, Herman, Laval, Kathlyn, Nauwynck, Hans, Poelaert, Katrien, Van Cleemput, Jolien, Van Den Broeck, Wim   +7 more
core   +1 more source

The MATSim Network Flow Model for Traffic Simulation Adapted to Large-Scale Emergency Egress and an Application to the Evacuation of the Indonesian City of Padang in Case of a Tsunami Warning [PDF]

, 2009
The evacuation of whole cities or even regions is an important problem, as demonstrated by recent events such as evacuation of Houston in the case of Hurricane Rita or the evacuation of coastal cities in the case of Tsunamis.
Klüpfel, Hubert, Lämmel, Gregor, Nagel, Kai   +2 more
core   +1 more source

Monitoring of dynamin during the Toxoplasma gondii cell cycle [PDF]

, 2016
The obligate intracellular protozoan parasite Toxoplasma gondii actively invades virtually all warm-blooded nucleated cells. This process results in a non-fusogenic vacuole, inside which the parasites replicate continuously until egress signaling is ...
Attias, Marcia, Caldas, Lucio Ayres, de Souza, Wanderley, Lemgruber Soares, Leandro, Seabra, Sergio Henrique   +4 more
core   +1 more source

Generation and characterization of monoclonal antibodies specific for the Pseudorabies Virus nuclear egress complex

Virus Research, 2020
During herpesvirus replication, newly synthesized nucleocapsids exit the nucleus by a vesicle-mediated transport, which requires the nuclear egress complex (NEC), composed of the conserved viral proteins designated as pUL31 and pUL34 in the alphaherpesviruses pseudorabies virus (PrV) and herpes simplex viruses.
Julia E, Hölper, Sven, Reiche, Kati, Franzke, Thomas C, Mettenleiter, Barbara G, Klupp   +4 more
openaire   +2 more sources

The Oligomeric Assemblies of Cytomegalovirus Core Nuclear Egress Proteins Are Associated with Host Kinases and Show Sensitivity to Antiviral Kinase Inhibitors

Viruses, 2022
The nucleo-cytoplasmic capsid egress of herpesviruses is a unique regulated process that ensures the efficiency of viral replication and release. For human cytomegalovirus (HCMV), the core of the nuclear egress complex (NEC) consists of the pUL50–pUL53 ...
Jintawee Kicuntod, Sigrun Häge, Friedrich Hahn, Heinrich Sticht, Manfred Marschall   +4 more
doaj   +1 more source

Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion [PDF]

, 2013
Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites
A Fomovska, AE Topolska, B Lige, B Shen, BF Kafsack, BJ Luft, C Lord, CA Hunter, Chetan E. Chitnis, Christian Slomianny, CY He, D Richard, DL Alexander, F Parussini, H El Hajj, HC Hoppe, HC Hoppe, I Mellman, J Schrevel, JB Dacks, JC Boothroyd, JE Rothman, JF Dubremetz, JM Harper, K Kremer, K Miranda, KA Joiner, KA Joiner, KM Hager, L Pelletier, L Sheiner, LH Bannister, LH Bannister, LM Kats, M Elias, M Tufet-Bayona, M Yang, Markus Meissner, ME Francia, MH Ngo, MH Ngo, MK Shaw, MS Breinich, MS Marks, NA Counihan, PJ Bradley, PJ Sloves, S Mogelsvang, SD Brydges, Stanislas Tomavo, VB Carruthers, Vern B. Carruthers, WM Henne, X Que, Z Dou   +54 more
core   +2 more sources