Results 31 to 40 of about 26,575 (247)
Human cytomegalovirus UL97 phosphorylates the viral nuclear egress complex. [PDF]
J Virol, 2015 ABSTRACT Herpesvirus nucleocapsids exit the host cell nucleus in an unusual process known as nuclear egress. The human cytomegalovirus (HCMV) UL97 protein kinase is required for efficient nuclear egress, which can be explained by its phosphorylation of the nuclear lamina component lamin A/C, which disrupts the nuclear lamina.
Sharma M +7 more
europepmc +5 more sources
Proteomic analysis of the multimeric nuclear egress complex of human cytomegalovirus. [PDF]
Mol Cell Proteomics, 2014 Herpesviral capsids are assembled in the host cell nucleus before being translocated into the cytoplasm for further maturation. The crossing of the nuclear envelope represents a major event that requires the formation of the nuclear egress complex (NEC).
Milbradt J +14 more
europepmc +6 more sources
The crystal structure of the varicella-zoster Orf24-Orf27 nuclear egress complex spotlights multiple determinants of herpesvirus subfamily specificity. [PDF]
J Biol Chem, 2022 ABSTRACTVaricella zoster virus (VZV) is a human pathogen from the α-subfamily of herpesviruses. Here, the crystal structure of the VZV Orf24-Orf27 complex is described, representing the essential viral core nuclear egress complex (NEC) that orchestrates the egress of the preassembled capsids from the nucleus.
Schweininger J +14 more
europepmc +7 more sources
Preparation of the Human Cytomegalovirus Nuclear Egress Complex and Associated Proteins. [PDF]
Methods Enzymol, 2016 Herpesviruses, like most DNA viruses, replicate their genomes in the host cell nucleus. Their DNA is then packaged and assembled into viral nucleocapsids, which, in most cases, are too large to pass through the nuclear pore complex. Instead, herpesviruses use a complex multistep pathway, termed nuclear egress, to exit the nucleus.
Sharma M, Kamil JP, Coen DM.
europepmc +4 more sources
Viruses, 2021 The molecular mechanism affecting translocation of newly synthesized herpesvirus nucleocapsids from the nucleus into the cytoplasm is still not fully understood.
Anna D. Dorsch +5 more
doaj +1 more source
Structural Basis for Capsid Recruitment and Coat Formation during HSV-1 Nuclear Egress
Proceedings, 2020 During herpesvirus infection, nascent viral capsids egress the nucleus into the cytoplasm by an unusual mechanism whereby capsids bud at the inner nuclear membrane.
Elizabeth Draganova +3 more
doaj +3 more sources
Cells, 2022 Herpesviral nuclear egress is a fine-tuned regulatory process that defines the nucleocytoplasmic release of viral capsids. Nuclear capsids are unable to traverse via nuclear pores due to the fact of their large size; therefore, herpesviruses evolved to ...
Sigrun Häge, Manfred Marschall
doaj +1 more source
The Great (Nuclear) Escape: New Insights into the Role of the Nuclear Egress Complex of Herpesviruses. [PDF]
J Virol, 2015 ABSTRACT Herpesviruses are unusual among enveloped viruses because they bud twice yet acquire a single envelope. They are also the only known viruses that bud into the nuclear envelope. We discovered that the herpesvirus nuclear egress complex could bud membranes without the help of other proteins by forming a coat-like hexagonal scaffold ...
Bigalke JM, Heldwein EE.
europepmc +4 more sources
AbstractHerpesvirus capsids must exit the nucleus to undergo additional maturation steps in the cytoplasm, such as secondary envelopment. This process is orchestrated by the nuclear egress complex (NEC), a conserved heterodimer that deforms the inner nuclear membrane and facilitates capsid egress.
Sanders S +8 more
europepmc +2 more sources
Nuclear envelope budding and its cellular functions
Nucleus, 2023 The nuclear pore complex (NPC) has long been assumed to be the sole route across the nuclear envelope, and under normal homeostatic conditions it is indeed the main mechanism of nucleo-cytoplasmic transport.
Katharina S. Keuenhof +6 more
doaj +1 more source