Membrane deformation and scission by the HSV-1 nuclear egress complex. [PDF]
Nat Commun, 2014 The nuclear egress complex (NEC) of herpesviruses such as HSV-1 is essential for the exit of nascent capsids from the cell nucleus. The NEC drives nuclear envelope vesiculation in cells, but the precise budding mechanism and the potential involvement of cellular proteins are unclear.
Bigalke JM +3 more
europepmc +4 more sources
Identification of the Capsid Binding Site in the Herpes Simplex Virus 1 Nuclear Egress Complex and Its Role in Viral Primary Envelopment and Replication. [PDF]
J Virol, 2019 Takeshima K +5 more
europepmc +2 more sources
The Great (Nuclear) Escape: New Insights into the Role of the Nuclear Egress Complex of Herpesviruses. [PDF]
J Virol, 2015 ABSTRACT Herpesviruses are unusual among enveloped viruses because they bud twice yet acquire a single envelope. They are also the only known viruses that bud into the nuclear envelope. We discovered that the herpesvirus nuclear egress complex could bud membranes without the help of other proteins by forming a coat-like hexagonal scaffold ...
Bigalke JM, Heldwein EE.
europepmc +4 more sources
Abstract Herpesvirus capsids must exit the nucleus to undergo additional maturation steps in the cytoplasm, such as secondary envelopment. This process is orchestrated by the nuclear egress complex (NEC), a conserved heterodimer that deforms the inner nuclear membrane and facilitates capsid egress.
Sanders S +8 more
europepmc +2 more sources
Viruses, 2021 The molecular mechanism affecting translocation of newly synthesized herpesvirus nucleocapsids from the nucleus into the cytoplasm is still not fully understood.
Anna D. Dorsch +5 more
doaj +1 more source
Lysine 242 within Helix 10 of the Pseudorabies Virus Nuclear Egress Complex pUL31 Component Is Critical for Primary Envelopment of Nucleocapsids. [PDF]
J Virol, 2017 Rönfeldt S +3 more
europepmc +2 more sources
Structural Basis for Capsid Recruitment and Coat Formation during HSV-1 Nuclear Egress
Proceedings, 2020 During herpesvirus infection, nascent viral capsids egress the nucleus into the cytoplasm by an unusual mechanism whereby capsids bud at the inner nuclear membrane.
Elizabeth Draganova +3 more
doaj +3 more sources
Cells, 2022 Herpesviral nuclear egress is a fine-tuned regulatory process that defines the nucleocytoplasmic release of viral capsids. Nuclear capsids are unable to traverse via nuclear pores due to the fact of their large size; therefore, herpesviruses evolved to ...
Sigrun Häge, Manfred Marschall
doaj +1 more source
Nuclear envelope budding and its cellular functions
Nucleus, 2023 The nuclear pore complex (NPC) has long been assumed to be the sole route across the nuclear envelope, and under normal homeostatic conditions it is indeed the main mechanism of nucleo-cytoplasmic transport.
Katharina S. Keuenhof +6 more
doaj +1 more source
The Herpes Simplex Virus Protein pUL31 Escorts Nucleocapsids to Sites of Nuclear Egress, a Process Coordinated by Its N-Terminal Domain. [PDF]
PLoS Pathogens, 2015 Progeny capsids of herpesviruses leave the nucleus by budding through the nuclear envelope. Two viral proteins, the membrane protein pUL34 and the nucleo-phosphoprotein pUL31 form the nuclear egress complex that is required for capsid egress out of the ...
Christina Funk +7 more
doaj +1 more source