Results 21 to 30 of about 26,575 (247)

Unexpected features and mechanism of heterodimer formation of a herpesvirus nuclear egress complex. [PDF]

EMBO J, 2015
AbstractHerpesvirus nucleocapsids escape from the nucleus in a process orchestrated by a highly conserved, viral nuclear egress complex. In human cytomegalovirus, the complex consists of two proteins, UL50 and UL53. We solved structures of versions of UL53 and the complex by X‐ray crystallography.
Lye MF, Sharma M, El Omari K, Filman DJ, Schuermann JP, Hogle JM, Coen DM.   +6 more
europepmc   +6 more sources

Membrane deformation and scission by the HSV-1 nuclear egress complex. [PDF]

Nat Commun, 2014
The nuclear egress complex (NEC) of herpesviruses such as HSV-1 is essential for the exit of nascent capsids from the cell nucleus. The NEC drives nuclear envelope vesiculation in cells, but the precise budding mechanism and the potential involvement of cellular proteins are unclear.
Bigalke JM, Heuser T, Nicastro D, Heldwein EE.   +3 more
europepmc   +6 more sources

Host and Viral Factors Involved in Nuclear Egress of Herpes Simplex Virus 1

Viruses, 2021
Herpes simplex virus 1 (HSV-1) replicates its genome and packages it into capsids within the nucleus. HSV-1 has evolved a complex mechanism of nuclear egress whereby nascent capsids bud on the inner nuclear membrane to form perinuclear virions that ...
Jun Arii
doaj   +3 more sources

The universal suppressor mutation restores membrane budding defects in the HSV-1 nuclear egress complex by stabilizing the oligomeric lattice. [PDF]

PLoS Pathogens
Nuclear egress is an essential process in herpesvirus replication whereby nascent capsids translocate from the nucleus to the cytoplasm. This initial step of nuclear egress-budding at the inner nuclear membrane-is coordinated by the nuclear egress ...
Elizabeth B Draganova, Hui Wang, Melanie Wu, Shiqing Liao, Amber Vu, Gonzalo L Gonzalez-Del Pino, Z Hong Zhou, Richard J Roller, Ekaterina E Heldwein   +8 more
doaj   +2 more sources

Nuclear Egress Complexes of HCMV and Other Herpesviruses: Solving the Puzzle of Sequence Coevolution, Conserved Structures and Subfamily-Spanning Binding Properties

Viruses, 2020
Herpesviruses uniquely express two essential nuclear egress-regulating proteins forming a heterodimeric nuclear egress complex (core NEC). These core NECs serve as hexameric lattice-structured platforms for capsid docking and recruit viral and cellular ...
Manfred Marschall, Sigrun Häge, Marcus Conrad, Sewar Alkhashrom, Jintawee Kicuntod, Johannes Schweininger, Mark Kriegel, Josephine Lösing, Julia Tillmanns, Frank Neipel, Jutta Eichler, Yves A. Muller, Heinrich Sticht   +12 more
doaj   +3 more sources

The Herpesvirus Nuclear Egress Complex Component, UL31, Can Be Recruited to Sites of DNA Damage Through Poly-ADP Ribose Binding [PDF]

Scientific Reports, 2017
The herpes simplex virus (HSV) UL31 gene encodes a conserved member of the herpesvirus nuclear egress complex that not only functions in the egress of DNA containing capsids from the nucleus, but is also required for optimal replication of viral DNA and ...
Maxwell R. Sherry, Thomas J. M. Hay, Michael A. Gulak, Arash Nassiri, Renée L. Finnen, Bruce W. Banfield   +5 more
doaj   +2 more sources

‘Shared-Hook’ and ‘Changed-Hook’ Binding Activities of Herpesviral Core Nuclear Egress Complexes Identified by Random Mutagenesis

Cells, 2022
Herpesviruses replicate their genomes and assemble their capsids in the host cell nucleus. To progress towards morphogenesis in the cytoplasm, herpesviruses evolved the strategy of nuclear egress as a highly regulated process of nucleo-cytoplasmic capsid
Josephine Lösing, Sigrun Häge, Martin Schütz, Sabrina Wagner, Julia Wardin, Heinrich Sticht, Manfred Marschall   +6 more
doaj   +3 more sources

Varicella Zoster Virus ORF25 Gene Product: An Essential Hub Protein Linking Encapsidation Proteins and the Nuclear Egress Complex [PDF]

Journal of Proteome Research, 2011
Varicella zoster virus (VZV) ORF25 is a 156 amino acid protein belonging to the approximately 40 core proteins that are conserved throughout the Herpesviridae.
Arvin, Ann M., Baiker, Armin, Gersting, Soren W., Haas, Juergen, Haase, Rudolf, Lotz-Havla, Arnelie S., Muntau, Ania C., Pinto, Maria G. Vizoso, Pothineni, Venkata R., Sommer, Marvin, Woidy, Mathias   +10 more
core   +6 more sources

Mutational Functional Analysis of the Pseudorabies Virus Nuclear Egress Complex-Nucleocapsid Interaction. [PDF]

J Virol, 2020
Herpesviruses encode an exceptional vesicle formation and scission machinery, which operates at the inner nuclear membrane, translocating the viral nucleocapsid from the nucleus into the perinuclear space. The conserved herpesviral nuclear egress complex (NEC) orchestrates this process.
Rönfeldt S, Franzke K, Hölper JE, Klupp BG, Mettenleiter TC.   +4 more
europepmc   +4 more sources

NECing goes: flexibility of the herpesvirus nuclear egress complex

, 2023
AbstractThe nuclear egress complex (NEC) allows herpesvirus capsids to escape from the nucleus without breaking the nuclear envelope barrier. It assembles into a lattice on the inner nuclear membrane enveloping newly assembled nucleocapsids, which bud into the perinuclear space.
Pražák V, Mironova Y, Vasishtan D, Hagen C, Laugks U, Jensen Y, Sanders S, Heumann JM, Bosse JB, Klupp B, Mettenleiter TC, Grange M, Grünewald K.   +12 more
europepmc   +2 more sources