Results 61 to 70 of about 26,575 (247)

Biochemical, Biophysical, and Mutational Analyses of Subunit Interactions of the Human Cytomegalovirus Nuclear Egress Complex [PDF]

Journal of Virology, 2009
ABSTRACT Nuclear egress, the trafficking of herpesvirus nucleocapsids from the nucleus to the cytoplasm, involves two conserved viral proteins that form a complex at the nuclear envelope, referred to as the nuclear egress complex. In human cytomegalovirus, these two proteins are called UL50 and UL53. To study UL50 and UL53 in molecular detail,
Sam, My, Evans, Brady, Coen, Donald, Hogle, James   +3 more
openaire   +3 more sources

Transit Lightcurve Signatures of Artificial Objects [PDF]

, 2005
The forthcoming space missions, able to detect Earth-like planets by the transit method, will a fortiori also be able to detect the transit of artificial planet-size objects.
Luc F. A. Arnold, Tarter J.
core   +3 more sources

Tegument Assembly and Secondary Envelopment of Alphaherpesviruses. [PDF]

, 2015
Alphaherpesviruses like herpes simplex virus are large DNA viruses characterized by their ability to establish lifelong latent infection in neurons. As for all herpesviruses, alphaherpesvirus virions contain a protein-rich layer called "tegument" that ...
Crump, Colin M, Graham, Stephen C, Owen, Danielle J   +2 more
core   +6 more sources

Inhibition of Human Cytomegalovirus Particle Maturation by Activation of Liver X Receptor

Frontiers in Microbiology, 2022
Human cytomegalovirus (HCMV), a herpesvirus family member, is a large, complex enveloped virus. The activation of liver X receptor (LXR) can significantly inhibit the replication of HCMV and weaken the virulence of progeny virus (unpublished data).
Bingnan Liu, Bingnan Liu, Bingnan Liu, Yanping Ma, Yanping Ma, Yanping Ma, Yujing Huang, Yujing Huang, Yujing Huang, Zhongyang Liu, Zhongyang Liu, Zhongyang Liu, Qiang Ruan, Qiang Ruan, Qiang Ruan, Ying Qi, Ying Qi, Ying Qi   +17 more
doaj   +1 more source

Cytomegaloviral proteins that associate with the nuclear lamina: components of a postulated nuclear egress complex

Journal of General Virology, 2009
The nuclear egress of cytomegaloviral capsids traversing the nuclear envelope is dependent on a locally restricted destabilization of the rigid nuclear lamina. It has been suggested that the multi-component nuclear egress complex (NEC) that is formed is comprised of both viral and cellular proteins which act to recruit lamin-phosphorylating protein ...
Jens, Milbradt, Sabrina, Auerochs, Heinrich, Sticht, Manfred, Marschall   +3 more
openaire   +2 more sources

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Pathogen-host reorganization during Chlamydia invasion revealed by cryo-electron tomography [PDF]

, 2014
Invasion of host cells is a key early event during bacterial infection, but the underlying pathogen-host interactions are yet to be fully visualised in three-dimensional detail.
Hackstadt T., Louis C., Matsumoto A., Matsumoto A., Newhall W.J., Scidmore M.A., Ward M.E.   +6 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Highly basic clusters in the HSV-1 nuclear egress complex drive membrane budding by inducing lipid ordering [PDF]

, 2021
AbstractDuring replication of herpesviruses, capsids escape from the nucleus into the cytoplasm by budding at the inner nuclear membrane. This unusual process is mediated by the viral nuclear egress complex (NEC) that deforms the membrane around the capsid by oligomerizing into a hexagonal, membrane-bound scaffold.
Michael K. Thorsen, Alex Lai, Michelle W. Lee, David P. Hoogerheide, Gerard C. L. Wong, Jack H. Freed, Ekaterina E. Heldwein   +6 more
openaire   +1 more source

Structure of a herpesvirus nuclear egress complex subunit reveals an interaction groove that is essential for viral replication. [PDF]

Proc Natl Acad Sci U S A, 2015
SignificanceHuman cytomegalovirus (HCMV) is an important human pathogen. Current anti-HCMV therapies suffer from toxicities, drug resistance, and/or pharmacokinetic limitations. A possible antiviral drug target is a two-subunit complex that orchestrates nuclear egress, an essential, unusual mechanism by which nucleocapsids move from the nucleus to the ...
Leigh KE, Sharma M, Mansueto MS, Boeszoermenyi A, Filman DJ, Hogle JM, Wagner G, Coen DM, Arthanari H.   +8 more
europepmc   +5 more sources