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Trends in Biochemical Sciences, 2010
The nuclear export of mRNA, in which Mex67-Mtr2 mediates movement of mature transcripts through nuclear pores, represents the culmination of the nuclear portion of the gene expression pathway. Nuclear export is closely integrated with transcription and processing, and is based on forming a messenger ribonucleoprotein (mRNP) export complex in the ...
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The nuclear export of mRNA, in which Mex67-Mtr2 mediates movement of mature transcripts through nuclear pores, represents the culmination of the nuclear portion of the gene expression pathway. Nuclear export is closely integrated with transcription and processing, and is based on forming a messenger ribonucleoprotein (mRNP) export complex in the ...
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Nuclear Export of MicroRNA Precursors
Science, 2004MicroRNAs (miRNAs), which function as regulators of gene expression in eukaryotes, are processed from larger transcripts by sequential action of nuclear and cytoplasmic ribonuclease III–like endonucleases. We show that Exportin-5 (Exp5) mediates efficient nuclear export of short miRNA precursors (pre-miRNAs) and that its depletion by RNA interference ...
Elsebet, Lund +4 more
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International Security, 1978
The United States is now moving towards nonproliferation and nuclear export policies which will directly or tangentially affect the Soviet Union. Policymakers may be assuming that cooperation between the two countries on nuclear matters will be easy, and may be inclined to engage in a degree of mirror-imaging and wishful thinking about Soviet interests.
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The United States is now moving towards nonproliferation and nuclear export policies which will directly or tangentially affect the Soviet Union. Policymakers may be assuming that cooperation between the two countries on nuclear matters will be easy, and may be inclined to engage in a degree of mirror-imaging and wishful thinking about Soviet interests.
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International nuclear law and nuclear export controls
International Journal of Nuclear Law, 2011Evaluating the effectiveness of nuclear export controls necessitates a serious analysis of the circumstances in which they function and the elements that give them force, such as the international non-proliferation legal context, legal aspects of the regimes’ organisation and the national implementation of the guidelines agreed to by regime members ...
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Nuclear export of ribosomal subunits
Trends in Biochemical Sciences, 2002The partitioning of cells by a nuclear envelope ensures that precursors of ribosomes do not interact prematurely with other components of the translation machinery. Ribosomal subunits are assembled in nucleoli and exported to the cytoplasm in a CRM1/Ran-GTP-dependent fashion. Export of the large (60S) subunit requires a shuttling adaptor protein, NMD3,
Arlen W, Johnson +2 more
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Nuclear export of circular RNA
NatureCircular RNAs (circRNAs), which are increasingly being implicated in a variety of functions in normal and cancerous cells1-5, are formed by back-splicing of precursor mRNAs in the nucleus6-10. circRNAs are predominantly localized in the cytoplasm, indicating that they must be exported from the nucleus.
Linh H. Ngo +15 more
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Nuclear Export of Adenovirus RNA
2001Adenoviruses are medium-sized, non-enveloped DNA viruses which nowadays include well over 100 different serotypes found in a wide range of mammalian and avian hosts. The human adenoviruses comprise over 47 different serotypes which cause lytic and persistent infections and have been associated with a variety of clinical syndromes (reviewed in Horwitz ...
T, Dobner, J, Kzhyshkowska
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Nuclear import and export pathways
Journal of Cellular Biochemistry, 1999Macromolecules enter or leave the nucleus by using nuclear localization signals (NLS), or nuclear export signals (NES), respectively. Different types of NLS and NES are recognized directly or indirectly via adapters, by transport receptors. All transport receptors identified thus far are members of the same family and share an ability to shuttle ...
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Nuclear Export of Messenger RNA
2002Messenger RNAs (mRNAs) exist in the cell in dynamic association with multiple distinct proteins. The mRNA export cargo is therefore a ribonucleoprotein particle (mRNP). The most striking example of this are the Balbiani ring (BR) mRNPs of Chironomus tentans which are composed of an RNA molecule of 35–40 kb in length associated with about 500 protein ...
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Eukaryotic Ribosome Assembly and Nuclear Export
2015Accurate translation of the genetic code into functional polypeptides is key to cellular growth and proliferation. This essential process is carried out by the ribosome, a ribonucleoprotein complex of remarkable size and intricacy. Although the structure of the mature ribosome has provided insight into the mechanism of translation, our knowledge ...
Nerurkar Purnima +6 more
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