Results 191 to 200 of about 17,074,019 (238)
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Crocodylian nuclear factor kappa B
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2017We deduced the amino acid (aa) sequence of the nuclear factor kappa B (NFκB) protein from genomic data for the American alligator (Alligator mississippiensis), the estuarine crocodile (Crocodylus porosus), and the Indian gharial (Gavialis gangeticus).
Mark, Merchant +4 more
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Nuclear factor-kappa B and effector molecules in photoaging
Cutaneous and Ocular Toxicology, 2022Nuclear factor-kappa B (NF-κB) has important but complex functions in the photoaging of the human skin. This protein complex is activated upon UV irradiation and plays a key role in the signalling pathway of the inflammatory cascade. NF-κB induces the expression of various proinflammatory cytokines, such as tumour necrosis factor (TNF) and interleukin ...
Qiang, Zhang +3 more
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Nuclear factor kappa B and hepatitis viruses
Expert Opinion on Therapeutic Targets, 2008Hepatitis can be caused by a number of viruses, which have similar clinical manifestations and render infected individuals at high risk of death from cirrhosis and liver cancer. Current therapies for hepatitis have limited effects and unsatisfactory patient outcomes.
Yong-Song, Guan +3 more
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The Transcription Factor Nuclear Factor-kappa B and Cancer
Clinical Oncology, 2007Since the discovery of nuclear factor-kappa B (NF-kappaB) in 1986, many studies have been conducted showing the link between the NF-kappaB signalling pathway and control of the inflammatory response. Today it is well known that control of the inflammatory response and apoptosis is closely related to the activation of NF-kappaB.
R O, Escárcega +4 more
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2007
The Nuclear Factor-kappa B (NF-κB) represents a family of transcription factors that controls a variety of processes related to immunity and development. This family of transcription factors is conserved from insects to humans. Five different proteins, encoded by five different genes, of this family are present in mammals and three related proteins are
Keith W. Clem, Y. Tony Ip
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The Nuclear Factor-kappa B (NF-κB) represents a family of transcription factors that controls a variety of processes related to immunity and development. This family of transcription factors is conserved from insects to humans. Five different proteins, encoded by five different genes, of this family are present in mammals and three related proteins are
Keith W. Clem, Y. Tony Ip
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Nuclear Factor-Kappa B: From Clone to Clinic
Current Molecular Medicine, 2007Nuclear transcription factor kappaB (NF-kappaB) was first discovered in 1986 in the nucleus of the B cell as an enhancer in the kappa immunoglobulin chain. However, this factor has identified in the cytoplasm in the resting state. When activated in response to inflammatory stimuli, carcinogens, stress, ionizing radiation, and growth factors; NF-kappaB ...
Kwang Seok, Ahn +2 more
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Activation of nuclear factor kappa B in Crohn's disease
Inflammation Research, 1998The location and degree of activation of nuclear factor kappa (NFkappaB), a primary transcription factor that plays a regulating role in immune and inflammatory responses, was determined in Crohn's disease using full thickness specimens of bowel collected at surgery.Resected specimens of inflamed and non-inflamed bowel were collected from thirteen ...
R D, Ellis +5 more
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Nuclear Factor Kappa-B Activation by Particles and Fibers
Inhalation Toxicology, 2000In recent years, particle research has focused on activation pathways of transcription factors that are known to regulate genes whose abnormal expression is associated with the pathogenesis of particle-associated lung disorders such as fibrosis, cancer, COPD, and asthma.
R P, Schins, K, Donaldson
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Nuclear factor-kappa B in intestinal protection and destruction
Current Opinion in Gastroenterology, 2009Nuclear factor-kappa B (NF-kappaB) is a key transcriptional regulator of innate and adaptive immunity. This review highlights new insights into the functions of NF-kappaB in normal homeostasis and specific disease processes in the intestinal tract.Inflammatory bowel disease and experimental intestinal inflammation are characterized by NF-kappaB ...
Martina E, Spehlmann, Lars, Eckmann
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Nuclear factor kappa B activation by NADPH oxidases
Mechanisms of Ageing and Development, 2004Reactive oxygen species (ROS) initiate activation of the transcription factor NF-kappaB in a variety of cell systems. Perhaps the most potent biological source of ROS is the NADPH oxidase of phagocytic cells, a multi-component system that catalyzes the formation of superoxide anion.
Robert A, Clark, Anthony J, Valente
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