MicroRNA Roles in the Nuclear Factor Kappa B Signaling Pathway in Cancer
Frontiers in Immunology, 2018 Nuclear factor kappa B (NF-κB) is a pluripotent and crucial dimer transcription factor that orchestrates various physiological and pathological processes, especially cell proliferation, inflammation, and cancer development and progression.
Jin’en Wu +5 more
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TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma [PDF]
, 2009 Proliferation and survival of Hodgkin and Reed/Sternberg (HRS) cells, the malignant cells of classical Hodgkin lymphoma (cHL), are dependent on constitutive activation of nuclear factor {kappa}B (NF-{kappa}B).
Inga Vater +25 more
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The role of NF-kB in the mechanisms of inflammation of the stomach’s mucosa in children
Сучасна педіатрія: Україна, 2023 Introduction. One of the important and unresolved issues of pediatric gastroenterology remains study of inflammation mechanisms of the stomach’s mucosa, as well as factors that regulate inflammatory reactions.
V.І. Bobrova
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The role of nuclear factor kappa B in human labour [PDF]
Reproduction, 2005 Abstract Preterm birth remains the leading cause of perinatal mortality and morbidity, largely as a result of a poor understanding of the precise mechanisms controlling labour onset in humans. Inflammation has long been recognised as a key feature of both preterm and term labour, with an influx of inflammatory cells into the uterus ...
Tamsin M, Lindström, Phillip R, Bennett
openaire +2 more sources
Bridelia ferruginea Produces Anti-neuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling [PDF]
, 2012 Bridelia ferruginea is commonly used in traditional African medicine (TAM) for treating various inflammatory conditions. Extracts from the plant have been shown to exhibit anti-inflammatory property in a number of in vivo models.
Aderogba, Mutallib A. +6 more
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Lipopolysaccharide and tumor necrosis factor regulate Parkin expression via nuclear factor-kappa B. [PDF]
PLoS ONE, 2011 Inflammation and oxidative stress have been implicated in the pathophysiology of Parkinson's disease (PD) and inhibition of microglial activation attenuates degeneration of dopaminergic (DA) neurons in animal models of PD.
Thi A Tran +5 more
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Comparative analysis on the structural features of the 5' flanking region of kappa-casein genes from six different species [PDF]
, 2002 Kappa-casein plays an essential role in the formation, stabilisation and aggregation of milk micelles. Control of kappa-casein expression reflects this essential role, although an understanding of the mechanisms involved lags behind that of the other ...
C. Bruce A. Whitelaw, +16 more
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Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster [PDF]
, 2014 Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms. Molecularly, hypoxia activates a transcriptional programme directed at restoration of oxygen homoeostasis and cellular survival ...
Biddlestone, John +4 more
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The chemopreventive polyphenol Curcumin prevents hematogenous breast cancer metastases in immunodeficient mice [PDF]
, 2007 Dissemination of metastatic cells probably occurs long before diagnosis of the primary tumor. Metastasis during early phases of carcinogenesis in high risk patients is therefore a potential prevention target.
Iancu, Cristina M. +9 more
core +1 more source
Tumor necrosis factor-alpha activates the human prolactin gene promoter via nuclear factor-kappa B signaling [PDF]
, 2006 Pituitary function has been shown to be regulated by an increasing number of intrapituitary factors, including cytokines. Here we show that the important cytokine TNF-alpha activates prolactin gene transcription in pituitary GH3 cells stably expressing ...
Spiller DG +9 more
core +7 more sources