Results 31 to 40 of about 17,074,019 (238)

Role of nuclear factor‐kappa B in atherogenesis

Experimental Physiology, 1997
Transcription factors of the nuclear factor‐kappa B (NF‐kappa B)/Rel family have an important function in the regulation of a variety of genes involved in the inflammatory and proliferative responses of cells. Recent studies strongly indicate that the inducible transcription factor NF‐kappa B is involved in the pathogenesis of atherosclerosis ...
K, Brand, S, Page, A K, Walli, D, Neumeier, P A, Baeuerle   +4 more
openaire   +2 more sources

Nuclear Factor Kappa B Signaling Complexes in Acute Inflammation [PDF]

Antioxidants & Redox Signaling, 2020
Significance: Nuclear factor kappa B (NF-κB) is a master regulator of the inflammatory response and represents a key regulatory node in the complex inflammatory signaling network. In addition, selective NF-κB transcriptional activity on specific target genes occurs through the control of redox-sensitive NF-κB interactions.
Rius-Pérez, Sergio, Pérez, Salvador, Martí-Andrés, Pablo, Monsalve, María, Sastre, Juan   +4 more
openaire   +4 more sources

Tumor Necrosis Factor-α Contributes to Ischemia- and Reperfusion-Induced Endothelial Activation in Isolated Hearts [PDF]

, 1999
During myocardial reperfusion, polymorphonuclear neutrophil (PMN) adhesion involving the intercellular adhesion molecule-1 (ICAM-1) may lead to aggravation and prolongation of reperfusion injury.
Kelly, Ralph A., Stefan Zahler, Habazettl, Helmut, Goedecke, Axel, Becker, Bernhard F., Dieter A. Wolf, Christian Kupatt, Helmut Habazettl, Boekstegers, Peter, Bernhard F. Becker, Kupatt, Christian, Peter Boekstegers, Zahler, Stefan, Wolf, Dieter A., Ralph A. Kelly, Axel Goedecke   +15 more
core   +1 more source

Expression of Nuclear Factor Kappa B and Survivin in Psoriasis [PDF]

ISRN Dermatology, 2012
Background and Objective. Suppression of apoptosis has been proposed as a mechanism responsible for epidermal thickness in psoriasis. Survivin is a member of the inhibitor of apoptosis family. Nuclear factor kappa B (NF-κB) is one of the transcriptional factors that regulate many genes affecting apoptosis.
Gunduz, Kamer, Temiz, Peyker, Gencoglan, Gulsum, Inanir, Isil, Catalkaya, Arzu   +4 more
openaire   +2 more sources

A study of nuclear transcription factor-kappa B in childhood autism. [PDF]

PLoS ONE, 2011
BACKGROUND: Several children with autism show regression in language and social development while maintaining normal motor milestones. A clear period of normal development followed by regression and subsequent improvement with treatment, suggests a ...
Usha S Naik, Charitha Gangadharan, Kanakalatha Abbagani, Balakrishna Nagalla, Niranjan Dasari, Sunil K Manna   +5 more
doaj   +1 more source

Potential Role of Nuclear Factor 𝜿B in Diabetic Cardiomyopathy

Mediators of Inflammation, 2011
Diabetic cardiomyopathy entails the cardiac injury induced by diabetes independently of any vascular disease or hypertension. Some transcription factors have been proposed to control the gene program involved in the setting and development of related ...
O. Lorenzo, B. Picatoste, S. Ares-Carrasco, E. Ramírez, J. Egido, J. Tuñón   +5 more
doaj   +1 more source

The Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases

Genes and Diseases, 2021
The nuclear factor kappa B (NF-kB) family of transcription factors plays an essential role as stressors in the cellular environment, and controls the expression of important regulatory genes such as immunity, inflammation, death, and cell proliferation ...
Mohammad Reza Zinatizadeh, Bettina Schock, Ghanbar Mahmoodi Chalbatani, Peyman Kheirandish Zarandi, Seyed Amir Jalali, Seyed Rouhollah Miri   +5 more
doaj   +1 more source

Inhibitors of nuclear factor kappa B cause apoptosis in cultured macrophages

Mediators of Inflammation, 1997
The precise role of the transcription factor nuclear factor kappa B (NF- κB) in the regulation of cell survival and cell death is still unresolved and may depend on cell type and position in the cell cycle. The aim of this study was to determine if three
E. E. Mannick, J. Mishra, J. Marque, M. Clavell, M. J. S. Miller, P. D. Oliver   +5 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source