Results 31 to 40 of about 2,137,659 (362)

Nuclear Import of Adeno-Associated Viruses Imaged by High-Speed Single-Molecule Microscopy

Viruses, 2021
Understanding the detailed nuclear import kinetics of adeno-associated virus (AAV) through the nuclear pore complex (NPC) is essential for the application of AAV capsids as a nuclear delivery instrument as well as a target for drug development.
Samuel L. Junod, Jason Saredy, Weidong Yang   +2 more
doaj   +1 more source

Nuclear Import of the HIV-1 Core Precedes Reverse Transcription and Uncoating

bioRxiv, 2020
HIV-1 particles contain a core formed by ~1500 capsid protein monomers housing viral RNA. HIV-1 core uncoating---disassembly---is required for infection.
A. Selyutina, Mirjana Persaud, Kyeongeun Lee, V. KewalRamani, F. Diaz-Griffero   +4 more
semanticscholar   +1 more source

PP2A Regulates HDAC4 Nuclear Import [PDF]

Molecular Biology of the Cell, 2008
Different signal-regulated serine/threonine kinases phosphorylate class II histone deacetylases (HDACs) to promote nuclear export, cytosolic accumulation, and activation of gene transcription. However, little is known about mechanisms operating in the opposite direction, which, possibly through phosphatases, should promote class II HDACs nuclear entry ...
BRANCOLINI, Claudio, CERNOTTA, Nadia, DELLO RUSSO C., FOTI, Carmela, GALLINARI P, ORSATTI L., PALLAORO M., PARONI, Gabriela, STEINKUHLER C, TALAMO F.   +9 more
openaire   +3 more sources

Sodium Polyoxotungstate Inhibits the Replication of Influenza Virus by Blocking the Nuclear Import of vRNP. [PDF]

Microorganisms
Li Z, Duan Y, Yu Y, Su Y, Zhang M, Gao Y, Jiang L, Zhang H, Lian X, Zhu X, Ke J, Peng Q, Chen X.   +12 more
europepmc   +3 more sources

Nuclear protein import [PDF]

Current Opinion in Cell Biology, 1997
The defining feature of eukaryotic organisms is the cell nucleus. All nuclear proteins are synthesized in the cytoplasm and need to be imported through the nuclear pore complexes (NPCs) into the nucleus. Import can be directed by various signals, of which the classical nuclear localization signal (NLS) and the M9 import signal are the best ...
openaire   +3 more sources

Cytochrome oxidase subunit VI of Trypanosoma brucei is imported without a cleaved presequence and is developmentally regulated at both RNA and protein levels [PDF]

, 2001
Mitochondrial respiration in the African trypanosome undergoes dramatic developmental stage regulation. This requires co-ordinated control of components encoded by both the nuclear genome and the kinetoplast, the unusual mitochondrial genome of these ...
Benne R., Beverley S.M., Brun R., Carruthers V.B., Czichos J., Feagin J.E., Folsch H., Hahne K., Hauser R., Hausler T., Hirumi H., Kwast K.E., LeBowitz J.H., Matthews K.R., Osinga K.A., Overath P., Priest J.W., Roditi I., Sherwin T., Smagula C., Sogin M.L., Stuart K., Tasker M., Torri A.F., Tschudi C., Ullu E., Vassella E., Wirtz E., Woods A., Ziegelbauer K.   +29 more
core   +1 more source

Higher nucleoporin-Importinβ affinity at the nuclear basket increases nucleocytoplasmic import. [PDF]

, 2013
Several in vitro studies have shown the presence of an affinity gradient in nuclear pore complex proteins for the import receptor Importinβ, at least partially contributing to nucleocytoplasmic transport, while others have historically argued against the
Azimi, Mohammad, Mofrad, Mohammad
core   +10 more sources

Targeting nuclear import and export in hematological malignancies

Leukemia, 2020
The transport of proteins across the nuclear membrane is a highly regulated process, essential for the cell function. This transport is actively mediated by members of the karyopherin family, termed importins, or exportins, depending on the direction of ...
B. Nachmias, A. Schimmer
semanticscholar   +1 more source

Targeting nuclear transporters in cancer: Diagnostic, prognostic and therapeutic potential [PDF]

, 2016
The Karyopherin superfamily is a major class of soluble transport receptors consisting of both import and export proteins. The trafficking of proteins involved in transcription, cell signalling and cell cycle regulation among other functions across the ...
Aggarwal, Albee, Alnabulsi, Alshareeda, Altan, Angus, Behrens, Bernis, Blower, Brinkmann, Brinkmann, Cansizoglu, Chang, Christiansen, Dahl, Das, Dasso, Depping, Dikovskaya, Forbes, Gluz, Gontan, Gorlich, Gousias, Gousias, Gousias, Grupp, Gruss, Hashimoto, Hintersteiner, Hu, Huang, Huang, Huang, Hutchins, Hügel, Ishizawa, Jensen, Jiang, Kahle, Kau, Kazim, Kim, Kimura, King, Knauer, Kojima, Kosugi, Kudo, Kurisaki, Kutay, Kuusisto, Kuusisto, Lapalombella, Latvia, Lau, Laurila, Li, Liang, Liao, Lin, Lin, Lorenzato, Ma, Marfori, Martens-de Kemp, Melo, Mortezavi, Mosammaparast, Muller, Nevins, Noske, Parikh, Poon, Pumroy, Quan, Quensel, Rensen, Sakai, Scherf, Shen, Shi, Shiraki, Sillje, Smith, Smith, Soderholm, Song, Stawerski, Stella Tsai, Stewart, Tai, Torgerson, Turner, Turner, Wagstaff, Wang, Wang, Wang, Watt, Watt, Watt, Wellmann, Wiese, Winkler, Winnepenninckx, Wu, Yan, Yang, Yao, Yoshitake, Yu, Zender, Zheng, Zhou, Zhu, Zhu, Zienkiewicz   +117 more
core   +1 more source

Identification of a Small Molecule Inhibitor of Importin β Mediated Nuclear Import by Confocal On-Bead Screening of Tagged One-Bead One-Compound Libraries [PDF]

, 2010
In eukaryotic cells, proteins and RNAs are transported between the nucleus and the cytoplasm by nuclear import and export receptors. Over the past decade, small molecules that inhibit the nuclear export receptor CRM1 have been identified, most notably ...
Ambrus, Geza, Auer, Manfred, Bednenko, Janna, Gerace, Larry, Gstach, Hubert, Hintersteiner, Martin, Knox, Andrew J. S., Meisner, Nicole-Claudia, Schmied, Mario, Seifert, Jan-Marcus, Singer, Eric L.   +10 more
core   +1 more source