Results 41 to 50 of about 2,137,659 (362)

Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear import

Retrovirology, 2011
Background The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the
Sheehy Noreen, Yeo Geok P, Jarboui Mohamed, Tsuji Takahiro, Gu Lili, Hall William W, Gautier Virginie W   +6 more
doaj   +1 more source

Sorting pathways of mitochondrial inner membrane proteins [PDF]

, 1990
Two distinct pathways of sorting and assembly of nuclear-encoded mitochondrial inner membrane proteins are described. In the first pathway, precursor proteins that carry amino-terminal targeting signals are initially translocated via contact sites ...
Hartl, Franz-Ulrich, Horwich, Arthur, Mahlke, Kerstin, Martin, Jörg, Neupert, Walter, Pfanner, Nikolaus   +5 more
core   +2 more sources

Neutrino Interactions Importance to Nuclear Physics [PDF]

AIP Conference Proceedings, 2009
To appear in the proceedings of 6th International Workshop on Neutrino-Nucleus Interactions in the Few-GeV Region (NuInt09), Sitges, Spain, 18 - 22 May ...
J. E. Amaro, C. Maieron, M. Valverde, J. Nieves, M. B. Barbaro, J. A. Caballero, T. W. Donnelly, J. M. Udias, Federico Sanchez, M. Sorel, Luis Alvarez-Ruso   +10 more
openaire   +5 more sources

tRNAs promote nuclear import of HIV-1 intracellular reverse transcription complexes.

PLoS Biology, 2006
Infection of non-dividing cells is a biological property of HIV-1 crucial for virus transmission and AIDS pathogenesis. This property depends on nuclear import of the intracellular reverse transcription and pre-integration complexes (RTCs/PICs).
Lyubov Zaitseva, Richard Myers, Ariberto Fassati   +2 more
doaj   +1 more source

UV-induced nuclear import of XPA is mediated by importin-α4 in an ATR-dependent manner. [PDF]

PLoS ONE, 2013
Xeroderma pigmentosum Group A (XPA) is a crucial factor in mammalian nucleotide excision repair (NER) and nuclear import of XPA from the cytoplasm for NER is regulated in cellular DNA damage responses in S-phase.
Zhengke Li, Phillip R Musich, Brian M Cartwright, Hui Wang, Yue Zou   +4 more
doaj   +1 more source

p34cdc2-mediated phosphorylation at T124 inhibits nuclear import of SV-40 T antigen proteins [PDF]

, 1991
The nuclear import of transcription regulatory proteins appears to be used by the cell to trigger transitions in cell cycle, morphogenesis, and transformation.
Ackermann, M. J., Beach, D. H., Bischoff, J. R., Jans, D. A., Peters, R.   +4 more
core   +1 more source

Transportin-1: A Nuclear Import Receptor with Moonlighting Functions

Frontiers in Molecular Biosciences, 2021
Transportin-1 (Trn1), also known as karyopherin-β2 (Kapβ2), is probably the best-characterized nuclear import receptor of the karyopherin-β family after Importin-β, but certain aspects of its functions in cells are still puzzling or are just recently ...
Allegra Mboukou, Vinod Rajendra, Renata Kleinova, Carine Tisné, Michael F. Jantsch, Pierre Barraud   +5 more
doaj   +1 more source

The protein import apparatus of chloroplasts [PDF]

, 1993
Routing of cytosolically synthesized precursor proteins into chloroplasts is a specific process which involves a multitude of soluble and membrane components.
Bartling D., Bassham D. C., Buvinger W. E., Cline K., Cline K., Cline K., Heike Alefsen, Joyard J., Jürgen Soll, Kirwin P. M., Li H.‐M., Mould R. M., Olsen L. J., Olsen L. J., Perry S. E., Pilon M., Schnell D. J., Theg S. M.   +17 more
core   +1 more source

Molecular determinants of large cargo transport into the nucleus

eLife, 2020
Nucleocytoplasmic transport is tightly regulated by the nuclear pore complex (NPC). Among the thousands of molecules that cross the NPC, even very large (>15 nm) cargoes such as pathogens, mRNAs and pre-ribosomes can pass the NPC intact.
Giulia Paci, Tiantian Zheng, Joana Caria, Anton Zilman, Edward A Lemke   +4 more
doaj   +1 more source

The nuclear entry of the aryl hydrocarbon receptor (AHR) relies on the first nuclear localization signal and can be negatively regulated through IMPα/β specific inhibitors

Scientific Reports, 2023
The human aryl hydrocarbon receptor (AHR) undergoes continuous shuttling between nucleus and cytoplasm. Binding to exogenous or endogenous ligands promotes its rapid nuclear import.
Rashad Haidar, Reneh Shabo, Marie Moeser, Andreas Luch, Josephine Kugler   +4 more
doaj   +1 more source