Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through NUP62, inhibiting host nucleocytoplasmic transport pathways [PDF]
, 2012 The herpes simplex virus ICP27 protein is important for the expression and nuclear export of viral mRNAs. Although several binding sites have been mapped along the ICP27 sequence for various RNA and protein partners including the transport receptor TAP ...
Arnold +83 more
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Virology Journal, 2007 Background The influenza A virus replicates in the nucleus of its host cell. Thus, entry of the influenza genome into the cell nucleus is necessary for establishing infection.
Panté Nelly +2 more
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Cell biological mechanisms of activity-dependent synapse to nucleus translocation of CRTC1 in neurons. [PDF]
, 2015 Previous studies have revealed a critical role for CREB-regulated transcriptional coactivator (CRTC1) in regulating neuronal gene expression during learning and memory. CRTC1 localizes to synapses but undergoes activity-dependent nuclear translocation to
Ch'ng, Toh Hean +5 more
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Dynamics of the STAT3 transcription factor: nuclear import dependent on Ran and importin-β1. [PDF]
PLoS ONE, 2011 The signal transducer and activator of transcription-3 (STAT3) induces transcription of genes that control differentiation, inflammation, proliferation, and tumor cell invasion.
Velasco Cimica +3 more
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Changes in subcellular localization reveal interactions between human cytomegalovirus terminase subunits [PDF]
, 2012 BACKGROUND: During herpesvirus replication, terminase packages viral DNA into capsids. The subunits of herpes simplex virus terminase, UL15, UL28, and UL33, assemble in the cytoplasm prior to nuclear import of the complex.
McVoy, Michael A. +3 more
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Protoparvovirus Knocking at the Nuclear Door
Viruses, 2017 Protoparvoviruses target the nucleus due to their dependence on the cellular reproduction machinery during the replication and expression of their single-stranded DNA genome.
Elina Mäntylä +2 more
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Conservation of complex nuclear localization signals utilizing classical and non-classical nuclear import pathways in LANA homologs of KSHV and RFHV. [PDF]
PLoS ONE, 2011 ORF73 latency-associated nuclear antigen (LANA) of the Kaposi's sarcoma-associated herpesvirus (KSHV) is targeted to the nucleus of infected cells where it binds to chromatin and mediates viral episome persistence, interacts with cellular proteins and ...
Lidia Cherezova +2 more
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GAP activity, but not subcellular targeting, is required for Arabidopsis RanGAP cellular and developmental functions [PDF]
, 2015 The Ran GTPase activating protein (RanGAP) is important to Ran signaling involved in nucleocytoplasmic transport, spindle organization, and postmitotic nuclear assembly.
Boruc, Joanna +6 more
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eLife, 2019 Nuclear entry of HIV-1 replication complexes through intact nuclear pore complexes is critical for successful infection. The host protein cleavage-and-polyadenylation-specificity-factor-6 (CPSF6) has been implicated in different stages of early HIV-1 ...
D. Bejarano +9 more
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p53 stabilization: the importance of nuclear import [PDF]
Cell Death & Differentiation, 2010 In response to cellular stress, the p53 tumor suppressor protein is stabilized as a result of inactivation of ubiquitin-mediated degradation. The p53 protein rapidly accumulates in the nucleus, where it functions as a transcription factor. Although the regulation of p53 stability has been studied extensively, the subcellular compartment in which p53 ...
openaire +2 more sources