Results 141 to 150 of about 111,707 (190)

Micromanaging the nuclear lamina

Biophysical Journal
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Emerin preserves stem cell survival through maintenance of centrosome and nuclear lamina structure.

Development
Jones SD, Miller JEB, Amos MM, Hernández JM, Piaszynski KM, Geyer PK.   +5 more
europepmc   +1 more source

Laminopathies : the nuclear lamina alteration

, 2015
Mir Pérez, Cristina, Universitat Autònoma de Barcelona. Facultat de Biociències   +1 more
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Genome - nuclear lamina interactions are multivalent and cooperative

Dauban L, Eder M, de Haas M, Franceschini-Santos VH, Yañez-Cuna JO, van Schaik T, Leemans C, Rademaker K, Ara MM, Martinovic M, de Wit E, van Steensel B.   +11 more
europepmc   +1 more source

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Immunological analysis of nuclear lamina proteins

Chromosoma, 1980
Antibodies have been obtained against specific fractions of the nuclear lamina from chick red blood cells. Immunofluorescent staining of acrylamide gels from nuclear lamina preparations revealed a spectrum of at least 8-10 proteins cross-reacting immunologically with each other.
R, Stick, P, Hausen
openaire   +2 more sources

The nuclear lamina comes of age

Nature Reviews Molecular Cell Biology, 2005
Many nuclear proteins form lamin-dependent complexes, including LEM-domain proteins, nesprins and SUN-domain proteins. These complexes have roles in chromatin organization, gene regulation and signal transduction. Some link the nucleoskeleton to cytoskeletal structures, ensuring that the nucleus and centrosome assume appropriate intracellular positions.
Yosef, Gruenbaum, Ayelet, Margalit, Robert D, Goldman, Dale K, Shumaker, Katherine L, Wilson   +4 more
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The nuclear lamina and inherited disease

Trends in Cell Biology, 2002
Inherited disorders of the nuclear lamina present some of the most intriguing puzzles in cell biology. Mutations in lamin A and lamin C - nuclear intermediate filament proteins that are expressed in nearly all somatic cells - cause tissue-specific diseases that affect striated muscle, adipose tissue and peripheral nerve or skeletal development.
Howard J, Worman, Jean-Claude, Courvalin
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Genome–nuclear lamina interactions and gene regulation

Current Opinion in Cell Biology, 2010
The nuclear lamina, a filamentous protein network that coats the inner nuclear membrane, has long been thought to interact with specific genomic loci and regulate their expression. Molecular mapping studies have now identified large genomic domains that are in contact with the lamina.
Jop, Kind, Bas, van Steensel
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Functional mechanisms and abnormalities of the nuclear lamina

Nature Cell Biology, 2021
Alterations in nuclear shape are present in human diseases and ageing. A compromised nuclear lamina is molecularly interlinked to altered chromatin functions and genomic instability. Whether these alterations are a cause or a consequence of the pathological state are important questions in biology.
Adam Karoutas, Asifa Akhtar
openaire   +3 more sources

A new model for nuclear lamina organization

Biochemical Society Transactions, 2008
Lamins are intermediate filament proteins that form a network lining the inner nuclear membrane. They provide mechanical strength to the nuclear envelope, but also appear to have many other functions as reflected in the array of diseases caused by lamin mutations.
Martin W, Goldberg, Jindriska, Fiserova, Irm, Huttenlauch, Reimer, Stick   +3 more
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