Results 141 to 150 of about 1,508,553 (267)

Deep learning enabled prediction of nuclear lamina-associated chromatin. [PDF]

Patterns (N Y)
Das P, Lee JT.
europepmc   +1 more source

Differential contributions of nuclear lamina association and genome compartmentalization to gene regulation. [PDF]

Nucleus, 2023
Das P, San Martin R, McCord RP.
europepmc   +1 more source

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, EarlyView.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
wiley   +1 more source

Tau oligomerization induces nuclear lamina invagination and chromatin remodeling in Alzheimer's disease. [PDF]

Acta Neuropathol
Yuan S, Essepian N, Roberts R, Sherman E, Wang Q, Erisir A, Jiang L.   +6 more
europepmc   +1 more source

Ductile B2 Intermetallics‐Driven Strength‐Ductility Synergy in Heterolaminated Multi‐Principal Element Alloys

Advanced Science, EarlyView.
Intrinsic phase toughening transforms a brittle B2 intermetallic into a plastically deformable, load‐bearing phase, while a heterogeneous laminated architecture suppresses strain localization and interface cracking. The synergy between ductile intermetallics and mesoscale heterogeneity establishes a general design strategy for breaking the long ...
Lu Yang, Feilong Jiang, Qiming Zhuang, Dingshan Liang, Jiasi Luo, Kangjie Chu, Junhua Luan, Zengbao Jiao, Robert O. Ritchie, Fuzeng Ren   +9 more
wiley   +1 more source

The stability of the myelinating oligodendrocyte transcriptome is regulated by the nuclear lamina. [PDF]

Cell Rep, 2023
Pruvost M, Patzig J, Yattah C, Selcen I, Hernandez M, Park HJ, Moyon S, Liu S, Morioka MS, Shopland L, Al-Dalahmah O, Bendl J, Fullard JF, Roussos P, Goldman J, He Y, Dupree JL, Casaccia P.   +17 more
europepmc   +1 more source

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

Coordinated control of genome-nuclear lamina interactions by topoisomerase 2B and lamin B receptor. [PDF]

Nucleic Acids Res
van Schaik T, Magnitov M, de Haas M, Breda J, de Wit E, Manjon AG, Medema RH, Gothe HJ, Roukos V, Buckle AJ, Naughton C, Gilbert N, van Steensel B, Manzo SG.   +13 more
europepmc   +2 more sources

Mitotic dynamics of the nuclear lamina in the backstage of chromosome separation. [PDF]

Commun Biol
Picotto J, Bertrand P, Pennarun G.
europepmc   +1 more source

The nuclear lamina is required for proper development and nuclear shape distortion in tomato. [PDF]

J Exp Bot, 2023
Blunt EL, Choi J, Sussman H, Christopherson RC, Keen P, Rahmati Ishka M, Li LY, Idrovo JM, Julkowska MM, Van Eck J, Richards EJ.   +10 more
europepmc   +1 more source