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Mechanisms and dynamics of nuclear lamina–genome interactions
Current Opinion in Cell Biology, 2014The nuclear lamina (NL) interacts with the genomic DNA and is thought to influence chromosome organization and gene expression. Both DNA sequences and histone modifications are important for NL tethering of the genomic DNA. These interactions are dynamic in individual cells and can change during differentiation and development. Evidence is accumulating
Amendola, Mario, van Steensel, Bas
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[Laminopathies. Nuclear lamina diseases].
Medicina clinica, 2012Laminopathies are a group of diseases that share wrong codification of lamins, building proteins of the nuclear lamina. Different tissues are affected in those disorders: striated muscle, adipose tissue, central or peripheral nervous system and aging process. Emery-Dreifuss muscular dystrophy and Hutchinson-Gildford Progery Syndrome are two examples of
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Nuclear lamina regulates transposable elements activation
2017Genome of Eukaryotic organisms contain transposable elements that can move into new locations when are active. Consequences of transposable elements mobilization are new mutations, chromosomal rearrangements and genomic instability. Heterochromatin-mediated repression and post-transcriptional RNA silencing repress transposable elements activation.
Davide Andrenacci +2 more
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Mechanics and functional consequences of nuclear deformations
Nature Reviews Molecular Cell Biology, 2022Andrew D Stephens +2 more
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Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction
Cell, 2017Andrey Poleshko +2 more
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Lamina-Associated Domains: Links with Chromosome Architecture, Heterochromatin, and Gene Repression
Cell, 2017Bas van Steensel
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