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Inner nuclear membrane proteins and the nuclear lamina
Journal of Cell Science, 2001The nuclear lamina is a scaffolding structure at the nuclear periphery and is required for maintenance of nuclear shape, spacing of nuclear pore complexes, organization of heterochromatin, DNA replication, and regulation of transcription factors.
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Mechanisms of nuclear lamina growth in interphase
Histochemistry and Cell Biology, 2016The nuclear lamina represents a multifunctional platform involved in such diverse yet interconnected processes as spatial organization of the genome, maintenance of mechanical stability of the nucleus, regulation of transcription and replication. Most of lamina activities are exerted through tethering of lamina-associated chromatin domains (LADs) to ...
Oxana A, Zhironkina +6 more
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Organization and modulation of nuclear lamina structure
Journal of Cell Science, 1984ABSTRACT The nuclear lamina is a protein meshwork associated with the nucleoplasmic surface of the inner nuclear membrane, that is suggested to be important for organizing nuclear envelope and interphase chromosome architecture. To investigate the structural organization of the lamina, we have analysed rat liver nuclear envelopes by ...
L, Gerace, C, Comeau, M, Benson
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Relation between nuclear envelope and nuclear lamina in nuclear assemblyin vitro
Science in China Series C: Life Sciences, 1997Xenopus laevis egg extracts cell-free nuclear assembly system was used as an experimental model to study the process of nuclear lamina assembly in nuclear reconstitution in vitro. The experimental results showed that lamin was involved in the nuclear assembly in vitro.
S, Cai, Z, Zhai
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Functional differences between mammalian nuclear protein matrices and pore-lamina complex laminae
Experimental Cell Research, 1979Abstract Nuclear matrix isolated from rat liver in the presence of a serine protease inhibitor contained 85% of the rapidly-labelled hnRNA, but pore-lamina preparations from the same tissue contained virtually none of the rapidly-labelled material. Nuclear matrix from rat endometrium, but not from lung, contained high-affinity binding sites for 17β ...
P S, Agutter, K, Birchall
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Nuclear lamina and regulation of nuclear envelofe structure
Proceedings, annual meeting, Electron Microscopy Society of America, 1987The nuclear lamina is a protein meshwork that lines the nucleoplasmic surface of the nuclear envelope. In numerous higher eukaryotic cells, the lamina is known to contain a polymer of 1-3 major polypeptides (“lamins“) that form an insoluble supramolecular assembly during interphase.
Larry Gerace +3 more
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Assembly-disassembly of the nuclear lamina
Current Opinion in Cell Biology, 1992Recently, progress in the study of lamins has been made in three areas: signals required for targetting newly synthesized lamins to the correct subnuclear compartment have been identified; information on lamina assembly has been obtained from in vitro studies using bacterially expressed proteins; and a mechanistic explanation for how the nuclear lamina
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1990
During interphase, eukaryotic cells are physically separated into a nuclear and a cytoplasmic compartment by a complex organelle, the nuclear envelope. The innermost layer of the nuclear envelope is a polymeric protein network (Fawcett, 1966; Fawcett, 1981) termed the nuclear lamina (NL) (Fig.
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During interphase, eukaryotic cells are physically separated into a nuclear and a cytoplasmic compartment by a complex organelle, the nuclear envelope. The innermost layer of the nuclear envelope is a polymeric protein network (Fawcett, 1966; Fawcett, 1981) termed the nuclear lamina (NL) (Fig.
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Nuclear fibrous lamina in pathological human synovial membrane
Virchows Archiv B Cell Pathology, 1974The synovial membrane from a patient with multiple sclerosis, psoriasis and arthritis was examined with the electron microscope. A nuclear fibrous lamina much thicker than that known to occur in normal cells of vertebrates was found in the synovial intimal cells and in subsynovial fibroblasts of this patient. Since such a thickened lamina has also been
F N, Ghadially +2 more
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The nuclear lamina and heterochromatin: a complex relationship
Biochemical Society Transactions, 2011In metazoan cells, the heterochromatin is generally localized at the nuclear periphery, whereas active genes are preferentially found in the nuclear interior. In the present paper, we review current evidence showing that components of the nuclear lamina interact directly with heterochromatin, which implicates the nuclear lamina in a mechanism of ...
Erin M, Bank, Yosef, Gruenbaum
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