Results 31 to 40 of about 163,417 (257)

Alterations to nuclear architecture and genome behavior in senescent cells. [PDF]

, 2007
The organization of the genome within interphase nuclei, and how it interacts with nuclear structures is important for the regulation of nuclear functions.
Abney J.R., Agrelo R., Barboro P., Becker P.B., Bemiller P.M., Benn P.A., Berezney R., Bowman P.D., Bridger J.M., Bridger J.M., C. S. CLEMENTS, Campisi J., Chaly N., Chang K.S., Cremer T., de Lange T., Dell'Orco R.T., Dijkwel P.A., Ferbeyre G., Filesi I., Fisher A.G., Fleischer S., Goldman R.D., Gruenbaum Y., Haque F., Hernandez-Verdun D., Holliday R., Hozak P., I. R. KILL, I. S. MEHTA, J. M. BRIDGER, Kill I.R., Kreth G., Lezhava T., Li Y., M. FIGGITT, Mallette F.A., Manuelidis L., Mazin A.L., Mitsui Y., Mukherjee A.B., Nickerson J., Okabe J., Padiath Q.S., Pawelec G., Petrova N.V., Schardin M., Schulz L., Smilenov L.B., Strouboulis J., Tanabe H., van Driel R., Wang G.S.   +52 more
core   +1 more source

The intriguing plant nuclear lamina

Frontiers in Plant Science, 2014
The nuclear lamina is a complex protein mesh attached to the inner nuclear membrane, which is also associated with nuclear pore complexes. It provides mechanical support to the nucleus and nuclear envelope, and as well as facilitating the connection of ...
Malgorzata eCiska, Susana eMoreno Diaz De La Espina   +1 more
doaj   +1 more source

3D Single Molecule Super-Resolution Microscopy of Whole Nuclear Lamina

Frontiers in Chemistry, 2022
Single molecule (SM) super-resolution microscopies bypass the diffraction limit of conventional optical techniques and provide excellent spatial resolutions in the tens of nanometers without overly complex microscope hardware.
Ashley M. Rozario, Ashley M. Rozario, Alison Morey, Cade Elliott, Brendan Russ, Donna R. Whelan, Stephen J. Turner, Toby D. M. Bell   +7 more
doaj   +1 more source

Hi-C-constrained physical models of human chromosomes recover functionally-related properties of genome organization [PDF]

Scientific Reports 6, Article number: 35985 (2016), 2016
Combining genome-wide structural models with phenomenological data is at the forefront of efforts to understand the organizational principles regulating the human genome. Here, we use chromosome-chromosome contact data as knowledge-based constraints for large-scale three-dimensional models of the human diploid genome.
arxiv   +1 more source

Nuclear Envelope, Nuclear Lamina, and Inherited Disease [PDF]

, 2005
The nuclear envelope is composed of the nuclear membranes, nuclear lamina, and nuclear pore complexes. In recent years, mutations in nuclear-envelope proteins have been shown to cause a surprisingly wide array of inherited diseases.
Courvalin, Jean-Claude, Worman, Howard,
core   +4 more sources

Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing [PDF]

, 2016
The Xist long noncoding RNA orchestrates X chromosome inactivation, a process that entails chromosome-wide silencing and remodeling of the three-dimensional (3D) structure of the X chromosome.
Aznauryan, Erik, Blanco, Mario, Cerase, Andrea, Chen, Chun-Kan, Chow, Amy, Guttman, Mitchell, Jackson, Costanza, McDonel, Patrick, Ollikainen, Noah, Surka, Christine   +9 more
core   +1 more source

Role of lamins in 3D genome organization and global gene expression

Nucleus, 2019
Genome-wide mapping of lamin-B1-genome interactions has shown that gene-poor and transcriptionally inactive genomic regions are associated with the nuclear lamina.
Youngjo Kim, Xiaobin Zheng, Yixian Zheng
doaj   +1 more source

Restructuring of Lamina-Associated Domains in Senescence and Cancer

Cells, 2022
Induction of cellular senescence or cancer is associated with a reshaping of the nuclear envelope and a broad reorganization of heterochromatin. At the periphery of mammalian nuclei, heterochromatin is stabilized at the nuclear lamina via lamina ...
Aurélie Bellanger, Julia Madsen-Østerbye, Natalia M. Galigniana, Philippe Collas   +3 more
doaj   +1 more source

Deformation of the nucleus by TGFβ1 via the remodeling of nuclear envelope and histone isoforms

Epigenetics & Chromatin, 2022
The cause of nuclear shape abnormalities which are often seen in pre-neoplastic and malignant tissues is not clear. In this study we report that deformation of the nucleus can be induced by TGFβ1 stimulation in several cell lines including Huh7.
Ya-Hui Chi, Wan-Ping Wang, Ming-Chun Hung, Gunn-Guang Liou, Jing-Ya Wang, Pen-Hsiu Grace Chao   +5 more
doaj   +1 more source

Involvement of the Lamin Rod Domain in Heterotypic Lamin Interactions Important for Nuclear Organization [PDF]

, 2001
The nuclear lamina is a meshwork of intermediate-type filament proteins (lamins) that lines the inner nuclear membrane. The lamina is proposed to be an important determinant of nuclear structure, but there has been little direct testing of this idea.
Adam, Aebi, Benavente, Cao, Collas, Coulombe, Dwyer, Ellis, Fairley, Foisner, Furukawa, Furukawa, Geisler, Georgatos, Gerace, Glass, Gorlich, Hatzfeld, Heald, Heimburg, Heitlinger, Heitlinger, Izumi, Kammerer, Lenz-Bohme, Lorra, Lourim, Lupas, McKeon, McLean, Mical, Moir, Rober, Sasse, Senior, Snow, Spann, Stuurman, Stuurman, Sullivan, Taniura, Wilson, Ye, Ye   +43 more
core   +2 more sources