Nuclear lamina invaginations are not a pathological feature of C9orf72 ALS/FTD [PDF]
Acta Neuropathologica Communications, 2021 The most common genetic cause of familial and sporadic amyotrophic lateral sclerosis (ALS) is a GGGGCC hexanucleotide repeat expansion (HRE) in the C9orf72 gene.
Alyssa N. Coyne, Jeffrey D. Rothstein
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Autosomal Dominant Leukodystrophy: A Disease of the Nuclear Lamina [PDF]
Frontiers in Cell and Developmental Biology, 2019 The nuclear lamina is a fibrous meshwork of proteins found adjacent to the inner nuclear membrane that plays a critical role in the maintenance of nuclear architecture.
Q. Padiath
semanticscholar +5 more sources
Nuclear lamina dysfunction triggers a germline stem cell checkpoint
Nature Communications, 2018 Otefin is a nuclear lamina protein required for survival of Drosophila germ stem cells. Here the authors show that nuclear lamina dysfunction resulting from loss of Otefin activates a DNA damage-independent germ stem cell-specific checkpoint, mediated by
Lacy J. Barton +6 more
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Reorganization of the nuclear lamina and cytoskeleton in adipogenesis [PDF]
Histochemistry and Cell Biology, 2011 A thorough understanding of fat cell biology is necessary to counter the epidemic of obesity. Although molecular pathways governing adipogenesis are well delineated, the structure of the nuclear lamina and nuclear-cytoskeleton junction in this process are not.
Valerie L. R. M. Verstraeten +9 more
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The nuclear lamina is required for proper development and nuclear shape distortion in tomato. [PDF]
J Exp Bot, 2023 Blunt EL +10 more
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CTCF and cohesin promote focal detachment of DNA from the nuclear lamina. [PDF]
Genome Biol, 2022 van Schaik T +5 more
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Constitutive nuclear lamina–genome interactions are highly conserved and associated with A/T-rich sequence [PDF]
, 2012 In metazoans, the nuclear lamina is thought to play an important role in the spatial organization of interphase chromosomes, by providing anchoring sites for large genomic segments named lamina-associated domains (LADs).
Wouter Meuleman +8 more
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The nuclear lamina is a hub for the nuclear function of Jacob. [PDF]
Mol Brain, 2021 AbstractJacob is a synapto-nuclear messenger protein that couples NMDAR activity to CREB-dependent gene expression. In this study, we investigated the nuclear distribution of Jacob and report a prominent targeting to the nuclear envelope that requires NMDAR activity and nuclear import.
Samer S +4 more
europepmc +7 more sources
Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing [PDF]
Science, 2016 The Xist long noncoding RNA orchestrates X chromosome inactivation, a process that entails chromosome-wide silencing and remodeling of the three-dimensional (3D) structure of the X chromosome.
Chun-Kan Chen +9 more
semanticscholar +3 more sources
Structural Diversity and Distribution of Nuclear Matrix Constituent Protein Class Nuclear Lamina Proteins in Streptophytic Algae. [PDF]
Genome Biol EvolKosztyo BS, Richards EJ.
europepmc +2 more sources