Results 161 to 170 of about 1,480,665 (235)

Nuclear Lamins: A Molecular Bridge Coupling Extracellular Mechanical Cues to Intranuclear Signal Transduction and Gene Regulation. [PDF]

Int J Mol Sci
Yang S, Liu H, Kou H, Lai L, Zhang X, Xu Y, Sun Y, Chen B.   +7 more
europepmc   +1 more source

Biomechanical defects and rescue of cardiomyocytes expressing pathologic nuclear lamins. [PDF]

Cardiovasc Res, 2018
Laurini E, Martinelli V, Lanzicher T, Puzzi L, Borin D, Chen SN, Long CS, Lee P, Mestroni L, Taylor MRG, Sbaizero O, Pricl S.   +11 more
europepmc   +1 more source

TNFSF14/LIGHT responses in intestinal and oesophageal fibroblasts are differentially modulated by hydroxylase inhibitors

The Journal of Physiology, EarlyView.
Abstract figure legend LIGHT is a mutual mediator of intestinal and oesophageal fibroblast inflammation with common as well as tissue‐specific effects. Hydroxylase inhibitors can selectively suppress inflammatory factors in both cell types, albeit targeting different signalling pathways.
Cian M. Ohlendieck, Carlos Matellan, Cristina Bauset, Bella Raphael, Mary Nwaezeigwe, Emer Flynn, Kevin Okamoto, Desmond Winter, Colm Collins, Katie Doogan, Seán T. Martin, Glen Doherty, Seema S. Aceves, Mario C. Manresa   +13 more
wiley   +1 more source

Design, synthesis and evaluation of clickable photoaffinity probes for nuclear lamins. [PDF]

Bioorg Med Chem Lett
Warren J, Wang J, Li BX, Xiao X.
europepmc   +1 more source

Intranuclear localisation of KLF3‐AS1 under the balance of histone acetylation and methylation in BMSCs ameliorates cerebral ischaemia‒reperfusion injury by preserving microglial mitochondrial function and inhibiting inflammatory polarisation

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
Epigenetic activation of KLF3‐AS1 in BMSCs, characterised by increased H3K27 acetylation and decreased H3K27 trimethylation at its promoter, enhances BMSC viability, proliferation and migration. Exosomal KLF3‐AS1 is delivered to microglia, which mechanistically promotes ETV4 nuclear translocation to activate SIRT3 transcription, preserving microglial ...
Qian Li, Xiaowei Xie, Jie Chen, Yu Cao, Dingzhou Zhou   +4 more
wiley   +1 more source

Alpinetin Protects Against High‐Fat Diet‐Induced Hepatic Injury via Mitigating Oxidative Stress, and Ferroptosis Through Modulating LXRα

Food Frontiers, Volume 7, Issue 6, November 2026.
Alpinetin protects against high‐fat diet‐ or palmitic acid‐induced nonalcoholic fatty liver disease by restoring LXR‐α expression. Activation of LXR‐α reduces hepatic lipid accumulation through suppression of lipogenic genes while alleviating oxidative stress and ferroptosis, ultimately improving liver function and attenuating hepatic injury.
Yanzi Yang, Tianhao Yu, Yujia Chu, Xingyu Liu, Qingping Lu, Tushuai Li, Jie Zhang   +6 more
wiley   +1 more source

Quantitative Assessment of Mesoscale Cellular Order and Organization in the Mouse Hippocampus

Hippocampus, Volume 36, Issue 6, November 2026.
ABSTRACT The hippocampus is characterized by a stereotypical macroscopic structure, where the nuclei are densely and heterogeneously packed among different subregions of the hippocampus. Despite the fact that tissue‐specific cellular organization has been implicated in neural function, it has been technically challenging to quantitatively analyze ...
Konstantin Hein, Humberto Romero‐Limon, Conrad Möckel, Anne Karasinsky, Stephanie Möllmert, Jona Kayser, Alessio Zaccone, Jochen Guck, Tomohisa Toda   +8 more
wiley   +1 more source

Nuclear lamins and progerin are dispensable for antioxidant Nrf2 response to arsenic and cadmium. [PDF]

Cell Signal, 2017
Hashimoto K, Majumdar R, Tsuji Y.
europepmc   +1 more source

Histone Modifications at the Intersection of Aging, Neuroinflammation and Metabolism in Alzheimer's Disease

Aging Cell, Volume 25, Issue 11, November 2026.
This review examines how histone modifications integrate aging, metabolic dysfunction and neuroinflammation to shape persistent, cell‐type‐specific chromatin states in Alzheimer's disease. By distinguishing causal regulation from association through perturbation, persistence and reversibility, it highlights metabolic–epigenetic feedback loops and ...
Junyi Liang, Huawen Cao, Xiumin Ren, Nan Sha, Xueqing Han, Ling Jiang, Bin Liu, Weiming Zhao   +7 more
wiley   +1 more source

Nuclear Wrinkles Result From Geometric Adaptations to Cellular and Nuclear Morphological Changes in Epithelial Cells

Genes to Cells, Volume 31, Issue 6, November 2026.
Changes in cell geometry caused by increased cell density, F‐actin disruption, or trypsinization promote nuclear rounding and nuclear wrinkle (NW) formation. NWs arise through passive redistribution of excess nuclear surface area and are reversible, without detectable DNA damage, stress‐associated histone H3 Ser10 phosphorylation, or global nuclear ...
Le Minh Khoa, Yohei Kono, Takeshi Shimi, Hiroshi Kimura   +3 more
wiley   +1 more source