Results 151 to 160 of about 7,287 (212)

Heat Stress Triggers Nuclear Invagination and Spatial Compartmentalization of Protein Metabolism

Cell Proliferation, Volume 59, Issue 8, August 2026.
Cells adapt heat stress to shape a nuclear invagination region function as “protein metabolism hotspots”, where both protein production and degradation are enhanced. ABSTRACT Heat stress is a common challenge for cells, causing multiple types of cellular damage while triggering complex stress responses, including the highly conserved mechanism known as
Zhi‐Hao Zhang, Yuan‐Tao Qiu, Jing‐Yue Cao, Yi‐Feng Huang, Ye‐Lin Lan, Yu‐Li Zhao, Fu Wu, Chen‐Long Wang, Guo‐Run Tang, Jing‐Yun Ji, Zhang Zhang, Guan‐Zheng Luo   +11 more
wiley   +1 more source

Resistance‐exercise‐induced stress intervenes in TGF‐β signaling by cooperatively downregulating nuclear αB‐crystallin and SMAD4 in human skeletal muscle fibers

The FEBS Journal, Volume 293, Issue 15, Page 4624-4644, August 2026.
Alpha‐crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor‐β (TGF‐β) signaling, enabling target gene transcription. We show nuclear CRYAB–SMAD4 interaction for the first time in human skeletal muscle fibers and its regulation by exercise.
Kirill Schaaf, Cassandra Duda, Tihomir Kostov, Patrick Diel, Käthe Bersiner, Wilhelm Bloch, Sebastian Gehlert, Daniel Jacko   +7 more
wiley   +1 more source

Fibroblasts lacking nuclear lamins do not have nuclear blebs or protrusions but nevertheless have frequent nuclear membrane ruptures. [PDF]

Proc Natl Acad Sci U S A, 2018
Chen NY, Kim P, Weston TA, Edillo L, Tu Y, Fong LG, Young SG.   +6 more
europepmc   +1 more source

Citrullination and Deamidation in Type 1 Diabetes: Linking Beta Cell Stress to Neoantigen‐Driven Autoimmunity

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Citrullination and deamidation are post‐translational modifications (PTMs) increasingly recognized as important contributors to neoepitope formation in type 1 diabetes (T1D). Under inflammatory and endoplasmic reticulum stress conditions, beta cells activate calcium‐dependent peptidylarginine deiminase and transglutaminase enzymes, leading to ...
Aïsha Callebaut, Ylke Bruggeman, Chantal Mathieu, Eddie A. James, Lut Overbergh   +4 more
wiley   +1 more source

EMF2 deficiency disrupts epigenetic and chromatin organization landscapes, blocking root regeneration competence in Arabidopsis

New Phytologist, Volume 251, Issue 4, Page 1792-1810, August 2026.
EMF2 mutation alters transcriptomic profiles in Arabidopsis calli while retaining responsiveness during root induction. Summary Plant de novo organogenesis depends on callus formation, yet the epigenetic mechanisms governing organ regeneration remain poorly understood.
Zhidan Wang, May Avraham, Tali Mandel, Leor Eshed Williams, Chang Liu   +4 more
wiley   +1 more source

Are there subsets of autoantibodies to nuclear lamins? [PDF]

Arthritis & Rheumatism, 1992
Jean‐Luc Senécal, Yves Raymond
openaire   +1 more source

Concentration-dependent Effects of Nuclear Lamins on Nuclear Size in Xenopus and Mammalian Cells. [PDF]

J Biol Chem, 2015
Jevtić P, Edens LJ, Li X, Nguyen T, Chen P, Levy DL.   +5 more
europepmc   +1 more source

Nuclear lamins and oxidative stress in cell proliferation and longevity. [PDF]

Adv Exp Med Biol, 2014
Shimi T, Goldman RD.
europepmc   +1 more source

The nucleus as a mechanobiological hub in muscle aging. [PDF]

Nucleus
Esen O, Battey E, Stroud MJ, Kirby TJ.
europepmc   +1 more source

Differential Predictive Roles of A- and B-Type Nuclear Lamins in Prostate Cancer Progression. [PDF]

PLoS One, 2015
Saarinen I, Mirtti T, Seikkula H, Boström PJ, Taimen P.   +4 more
europepmc   +1 more source