Results 131 to 140 of about 7,287 (212)

Berberine Inhibited Tumor Growth Through Suppressing the WDR54/β‐catenin Signal Pathway in Colorectal Cancer

Cell Biology International, Volume 50, Issue 8, August 2026.
ABSTRACT Berberine (BBR), a natural alkaloid, exhibits potent anti‐tumor activity in colorectal cancer (CRC), but its mechanisms are not fully elucidated. Analysis of GEO datasets (GSE216908 and GSE184414) identified WDR54 as a key target of BBR treatment. In vitro, BBR treatment of CRC cell lines (HT‐29 and SW480) markedly inhibited cell proliferation,
Qin Chen, Qi Chen, Fenqiong Tang
wiley   +1 more source

Anticancer Pyrroloquinazoline LBL1 Targets Nuclear Lamins. [PDF]

ACS Chem Biol, 2018
Li BX, Chen J, Chao B, David LL, Xiao X.
europepmc   +1 more source

Unveiling New Insights: Reinterpreting DES Mutation, p.Arg383His, Through a Study of an Iranian Family With Isolated Hypertrophic Cardiomyopathy, Implication for Phenotype–Genotype Correlation Analysis

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Desmin, a crucial intermediate filament in muscle cells, maintains structural integrity in cardiac muscle and provides stability to striated muscle cells. Mutations in the DES gene lead to desminopathies, causing diverse cardiac and skeletal myopathies.
Saeideh Kavousi, Farzad Kamali, Bahareh Rabbani, Mehrdad Behmanesh, Nejat Mahdieh, Mehrdad Noruzinia   +5 more
wiley   +1 more source

The transcription factor Hey and nuclear lamins specify and maintain cell identity. [PDF]

Elife, 2019
Flint Brodsly N, Bitman-Lotan E, Boico O, Shafat A, Monastirioti M, Gessler M, Delidakis C, Rincon-Arano H, Orian A.   +8 more
europepmc   +1 more source

Exosomal TGM2 From Hypoxia‐Primed Olfactory Mucosa MSCs Attenuates Senescent Astrocytes via NRF1/TFAM Signaling in Parkinson's Disease

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Hypoxia‐preconditioned olfactory mucosa mesenchymal stem cells (OM‐MSCs) release exosomes enriched with transglutaminase 2 (TGM2), which are taken up by astrocytes. Inside the nucleus, TGM2 activates NRF1, leading to the upregulation of TFAM. This enhances mitochondrial function by reducing mitochondrial DNA (mtDNA) leakage and improving mitochondrial ...
Xiqi Hu, Yuchang Liang, Hong Fan, Wenqi Fan, Zijie Wang, Ya‐nan Ma, Peipei Song, Ying Xia   +7 more
wiley   +1 more source

Quantitative Analysis of Nuclear Lamins Imaged by Super-Resolution Light Microscopy. [PDF]

Cells, 2019
Kittisopikul M, Virtanen L, Taimen P, Goldman RD.   +3 more
europepmc   +1 more source

Indole‐3‐Propionic Acid Alleviates Metabolic Dysfunction‐Associated Fatty Liver Disease via AHR/AMPK Signaling Activation

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
IPA promotes AHR nuclear translocation and AMPK phosphorylation. Phosphorylated AMPK may in turn facilitate AHR translocation, suggesting a potential reciprocal interplay that contributes to alleviating hepatic lipid deposition in MAFLD. ABSTRACT Metabolic dysfunction‐associated fatty liver disease (MAFLD) is a health problem worthy of attention ...
Yanting Huang, Meimei Yu, Jiaxin Lu, Chujun Lin, Shuhuan Li, Yalin Chen, Xin Chen, Hongliang Xue, Jing Chen, Lijie Su   +9 more
wiley   +1 more source

Unweaving the role of nuclear Lamins in neural circuit integrity. [PDF]

Cell Stress, 2018
Deal SL, Yamamoto S.
europepmc   +1 more source

Myocardial Lipid Metabolism Imbalance: The Pathological Core and Novel Diagnostic‐Therapeutic Directions of Cardiovascular Diseases

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
In cardiac cells, Plin5/AMPK regulate lipid homeostasis; excess CD36‐mediated uptake drives lipotoxicity, mitochondrial dysfunction, and CVDs (e.g., heart failure). Biomarkers (ApoB/ApoA‐1) and therapies (SGLT2 inhibitors) target this cascade. ABSTRACT Cardiac lipid metabolism is fundamental to myocardial energy homeostasis, with fatty acid oxidation ...
Peiyun Xie, Qun Zeng, Hongrui Wang, Meihua She   +3 more
wiley   +1 more source

Correction: An evolutionarily conserved role for separase in the regulation of nuclear lamins. [PDF]

Cell Death Discov
Cipressa F, Pennarun G, Bosso G, Rosignoli S, Tullo L, Schiralli N, Di Dio C, Borghi C, Paiardini A, Esposito G, Goldberg ML, Bertrand P, Cenci G.   +12 more
europepmc   +1 more source