Results 121 to 130 of about 13,819 (261)

Lamin A/C Haploinsufficiency Modulates the Differentiation Potential of Mouse Embryonic Stem Cells [PDF]

, 2013
BACKGROUND: Lamins are structural proteins that are the major determinants of nuclear architecture and play important roles in various nuclear functions including gene regulation and cell differentiation.
Chaturvedi, P., Kumar, S., Kumaran, R. I., Parnaik, V. K., Sehgal, P.   +4 more
core   +2 more sources

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Implications and Assessment of the Elastic Behavior of Lamins in Laminopathies

Cells, 2016
Lamins are mechanosensitive and elastic components of the nuclear lamina that respond to external mechanical cues by altering gene regulation in a feedback mechanism.
Subarna Dutta, Maitree Bhattacharyya, Kaushik Sengupta   +2 more
doaj   +1 more source

Nuclear filaments: role in chromosomal positioning and gene expression

Nucleus, 2020
Nuclear lamins form an elastic meshwork underlying the inner nuclear membrane and provide mechanical rigidity to the nucleus and maintain shape. Lamins also maintain chromosome positioning and play important roles in several nuclear processes like ...
Manindra Bera, Kaushik Sengupta
doaj   +1 more source

Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive progeroid traits [PDF]

, 2018
Human AKTIP and mouse Ft1 are orthologous ubiquitin E2 variant proteins involved in telomere maintenance and DNA replication. AKTIP also interacts with A- and B-type lamins.
Ana, Cumano, Bartolazzi, Armando, Bucciarelli, Elisabetta, Burla, Romina, Carcuro, Mariateresa, DEL GIUDICE, Simona, Gatti, Maurizio, Giulia, Piaggio, Ilaria, Virdia, Isabella, Manni, LA TORRE, Mattia, Merigliano, Chiara, Mottini, Carla, RAMPIONI VINCIGUERRA, GIAN LUCA, Riminucci, Mara, Saggio, Isabella, Silvia, Soddu, Verni', Fiammetta, Zanetti, Giorgia   +18 more
core   +1 more source

Astrocytic Mitochondria Transplantation Rescues Neuron Loss and Dendritic Injuries in Acute Cerebral Ischemic Stroke Mouse Model by Flexibly Regulating Mitochondria Dynamics

Annals of Neurology, EarlyView.
Objective Cerebral ischemic stroke causes neuronal oxygen/energy deprivation, disrupting mitochondrial function including reduced membrane potential and bioenergetics, exacerbating neuronal injury. Mitochondrial defects are, therefore, a central neuropathological node and potential therapeutic target.
Ning Bian, Jianing Shen, Linwei Tian, Jinghui Li, Lu Yang, Bo Yuan, Shulin Li, Yuyu Niu, Lu Zhao, Jingkuan Wei   +9 more
wiley   +1 more source

A new function for nuclear lamins: providing surface tension to the nuclear drop. [PDF]

Curr Opin Biomed Eng, 2023
Dickinson RB, Lele TP.
europepmc   +1 more source

Lamin A/C sustains PcG protein architecture, maintaining transcriptional repression at target genes [PDF]

, 2015
Beyond its role in providing structure to the nuclear envelope, lamin A/C is involved in transcriptional regulation. However, its cross talk with epigenetic factors--and how this cross talk influences physiological processes--is still unexplored.
Alessio Zippo, Alice Cortesi, Annagiusi Gargiulo, Asp, Ball, Bantignies, Bantignies, Beard, Beatrice Bodega, Bolte, Breiling, Caretti, Carpenter, Chiara Lanzuolo, Chiara Mozzetta, Cmarko, Cohen, Collas, Collins, Daniela Palacios, Delest, Dialynas, Elisa Cesarini, Fabrizia Marullo, Favreau, Francesco Gregoretti, Fredriksson, Frock, Gennaro Oliva, Gruenbaum, Gruenbaum, Harr, He, Hozák, Huang, Jahn, Juan, Kind, Kolb, Lanzuolo, Lanzuolo, Lanzuolo, Laura Antonelli, Lee, Lo Sardo, Lund, Marta Columbaro, Masny, Mattout, McCord, Melcon, Moir, Muñoz-Alarcón, Méjat, Oldenburg, Otsu, Palacios, Paro, Relaix, Riemer, Rosenblatt, Russ, Röber, Satijn, Scaffidi, Schiaffino, Schuettengruber, Schulze, Sezgin, Shimi, Shumaker, Simona Di Pelino, Solovei, Stefano Squarzoni, Stewart, Sullivan, Tolhuis, Trapnell, Wang, Wang, Woodhouse, Zaremba-Czogalla, Zwerger, Šmigová   +83 more
core   +1 more source

Harnessing Cellular Feeling: Epigenetic to Mechanical Memory as a Framework for Stem Cell Manufacturing

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Stem cell‐based therapies hold transformative potential for regenerative medicine, yet their progress is constrained by persistent variability in manufacturing and clinical performance. Conventional frameworks such as Quality by Design (QbD), though effective for drugs and biologics, struggle to accommodate the dynamic nature of living cell ...
Mee‐Hae Kim, Masahiro Kino‐oka
wiley   +1 more source

Interdependent changes of nuclear lamins, nuclear pore complexes, and ploidy regulate cellular regeneration and stress response in the heart. [PDF]

Nucleus, 2023
Li Y, Bertozzi A, Mann MR, Kühn B.
europepmc   +1 more source