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The nuclear lamins: flexibility in function
Nature Reviews Molecular Cell Biology, 2012The nuclear lamina is an important structural determinant for the nuclear envelope as a whole, attaching chromatin domains to the nuclear periphery and localizing some nuclear envelope proteins. The major components of the lamina are the A-type and B-type lamins, which are members of the intermediate filament protein family. Whereas the expression of A-
Colin L Stewart +2 more
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Scaffold, mechanics and functions of nuclear lamins
FEBS Letters, 2023Nuclear lamins are type‐V intermediate filaments that are involved in many nuclear processes. In mammals, A‐ and B‐type lamins assemble into separate physical meshwork underneath the inner nuclear membrane, the nuclear lamina, with some residual fraction localized within the nucleoplasm.
Ohad Medalia
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Nuclear Lamins: Their Structure, Assembly, and Interactions
Journal of Structural Biology, 1998Nuclear lamins are intermediate filament-type proteins that are the major building blocks of the nuclear lamina, a fibrous proteinaceous meshwork underlying the inner nuclear membrane. Lamins can also be localized in the nuclear interior, in a diffuse or spotted pattern.
Nico Stuurman, Ueli Aebi
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Functions of the nuclear lamins
Protoplasma, 2000The nuclear lamina is a filamentous structure, composed of lamins, that supports the inner nuclear membrane. Several integral membrane proteins including LBR (lamin B receptor), LAP (lamin-associated polypeptide) 1, and LAP 2 bind nuclear lamins in vitro and may influence lamin function and dynamics in vivo.
C J Hutchison
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The nuclear envelope, lamins and nuclear assembly
Current Opinion in Cell Biology, 2002The nuclear lamina is composed of both A- and B-type lamins and lamin-binding proteins. Many lamin-binding proteins are integral proteins of the inner nuclear membrane. Lamins and inner nuclear membrane proteins are important for a variety of cell functions, including nuclear assembly, replication, transcription, and nuclear integrity.
James M, Holaska +2 more
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Neurology, 2012
ADLD= : adult-onset autosomal dominant leukodystrophy; CMT= : Charcot-Marie-Tooth; EDMD= : Emery-Dreifuss muscular dystrophy; LAP= : lamin-associated polypeptide; LBR= : lamin B receptor; LGMD1B= : autosomal dominant limb-girdle muscular dystrophy The nuclear envelope is the interface between the nucleus and the rest of the cell and ...
CORTELLI, PIETRO +3 more
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ADLD= : adult-onset autosomal dominant leukodystrophy; CMT= : Charcot-Marie-Tooth; EDMD= : Emery-Dreifuss muscular dystrophy; LAP= : lamin-associated polypeptide; LBR= : lamin B receptor; LGMD1B= : autosomal dominant limb-girdle muscular dystrophy The nuclear envelope is the interface between the nucleus and the rest of the cell and ...
CORTELLI, PIETRO +3 more
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Nuclear lamins, diseases and aging
Current Opinion in Cell Biology, 2006Nuclear lamins are type V intermediate filament proteins. They are the major building blocks of the peripheral nuclear lamina, a complex meshwork of proteins underlying the inner nuclear membrane. In addition to providing nuclear shape and mechanical stability, they are required for chromatin organization, transcription regulation, DNA replication ...
Anna, Mattout +4 more
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Autoantibodies to Nuclear Lamins
Annals of Internal Medicine, 1988Excerpt In this issue, Lassoued and colleagues (1) describe findings related to the presence of autoantibodies to lamin proteins B, A, and C in a heterogeneous group of patients with thrombocytopen...
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1999
Abstract The nuclear lamins are intermediate filament proteins that are found exclusively in the cell nucleus of most multicellular animals and probably plants. The lamins assemble to form the nuclear lamina at the nuclear periphery. There also appear to be lamin assemblies within the nucleus. The lamins have been implicated as the major
Robert D Moir +2 more
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Abstract The nuclear lamins are intermediate filament proteins that are found exclusively in the cell nucleus of most multicellular animals and probably plants. The lamins assemble to form the nuclear lamina at the nuclear periphery. There also appear to be lamin assemblies within the nucleus. The lamins have been implicated as the major
Robert D Moir +2 more
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Mapping Nuclear Lamin-Genome Interactions by Chromatin Immunoprecipitation of Nuclear Lamins
2016The nuclear lamina is a meshwork of A- and B-type lamins which interact with chromatin and regulate many nuclear functions. Recent studies have reported the discovery of chromatin domains interacting with nuclear lamins by chromatin immunoprecipitation (ChIP) of lamin A/C or B1 and identification of the associated DNA sequences by microarray or high ...
Anja R, Oldenburg, Philippe, Collas
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