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Redistribution of nuclear lamins in mitotic cells
Biology of the Cell, 1986The nuclear lamins are directed from the cytoplasm to chromosomes as part of the maturation pathway of the interphase nucleoskeleton. In mitosis, the three polypeptides lamin A, B and C were found in the cytoplasm from prophase until anaphase and shifted to chromosomal surfaces at telophase (Ely, D'Arcy and Jost, 1978; Gerace, Blum and Blobel, 1978 ...
E, Jost +4 more
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Interaction between Emerin and Nuclear Lamins
Journal of Biochemistry, 2001Emerin is an inner nuclear membrane protein that is involved in X-linked recessive Emery-Dreifuss muscular dystrophy (X-EDMD). Although the function of this protein is still unknown, we revealed that C-terminus transmembrane domain-truncated emerin (amino acid 1-225) binds to lamin A with higher affinity than lamin C.
M, Sakaki +6 more
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The nuclear lamins are major determinants of nuclear architecture
The FASEB Journal, 2017The major structural components of the nuclear lamina are the Type V intermediate filament proteins, the nuclear lamins. There are four nuclear lamin isoforms (Lamins A, C, B1 and B2), which interact along with their binding partners to form a molecular interface between the inner nuclear envelope membrane and chromatin, the nuclear lamina in mammalian
Robert Goldman +7 more
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Nuclear Lamins: Thin Filaments with Major Functions
Trends in Cell Biology, 2018The nuclear lamina is a nuclear peripheral meshwork that is mainly composed of nuclear lamins, although a small fraction of lamins also localizes throughout the nucleoplasm. Lamins are classified as type V intermediate filament (IF) proteins. Mutations in lamin genes cause at least 15 distinct human diseases, collectively termed laminopathies ...
de Leeuw, Rebecca +2 more
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Nuclear Lamins: Laminopathies and Their Role in Premature Ageing
Physiological Reviews, 2006It has been demonstrated that nuclear lamins are important proteins in maintaining cellular as well as nuclear integrity, and in maintaining chromatin organization in the nucleus. Moreover, there is growing evidence that lamins play a prominent role in transcriptional control.
Broers, J.L.V. +4 more
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The structure and function of the nuclear lamins
Proceedings, annual meeting, Electron Microscopy Society of America, 1995The nuclear lamins are the Type V intermediate filament proteins comprising the nuclear lamina. The lamina is located subjacent to the nucleoplasmic face of the nuclear envelope where it interfaces with chromatin. The lamins are major karyoskeletal proteins which are thought to play important roles in the formation and maintenance of nuclear shape and ...
R.D. Goldman +5 more
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Role of A‐ and B‐type lamins in nuclear structure–function relationships
Biology of the Cell, 2021Kundan Sengupta
exaly
Posttranslational Processing of Nuclear Lamins
2011Publisher Summary This chapter reviews the posttranslational processing of the nuclear lamins and discusses its importance to health and disease. The nuclear lamina, a meshwork formed from intermediate filament proteins, provides structural scaffolding for the cell nucleus. The principal proteins of the nuclear lamina are lamin A, lamin B1, lamin B2,
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