Results 211 to 220 of about 1,480,665 (235)

Functions of the nuclear lamins

Protoplasma, 2000
The nuclear lamina is a filamentous structure, composed of lamins, that supports the inner nuclear membrane. Several integral membrane proteins including LBR (lamin B receptor), LAP (lamin-associated polypeptide) 1, and LAP 2 bind nuclear lamins in vitro and may influence lamin function and dynamics in vivo.
O. A. Vaughan, W. G. E. Whitfield, C. J. Hutchison   +2 more
openaire   +1 more source

Interaction between Emerin and Nuclear Lamins

Journal of Biochemistry, 2001
Emerin is an inner nuclear membrane protein that is involved in X-linked recessive Emery-Dreifuss muscular dystrophy (X-EDMD). Although the function of this protein is still unknown, we revealed that C-terminus transmembrane domain-truncated emerin (amino acid 1-225) binds to lamin A with higher affinity than lamin C.
M, Sakaki, H, Koike, N, Takahashi, N, Sasagawa, S, Tomioka, K, Arahata, S, Ishiura   +6 more
openaire   +2 more sources

Redistribution of nuclear lamins in mitotic cells

Biology of the Cell, 1986
The nuclear lamins are directed from the cytoplasm to chromosomes as part of the maturation pathway of the interphase nucleoskeleton. In mitosis, the three polypeptides lamin A, B and C were found in the cytoplasm from prophase until anaphase and shifted to chromosomal surfaces at telophase (Ely, D'Arcy and Jost, 1978; Gerace, Blum and Blobel, 1978 ...
E, Jost, K, Lepper, D, Högner, A, Zimmer, B, Boschek   +4 more
openaire   +2 more sources

The nuclear lamins are major determinants of nuclear architecture

The FASEB Journal, 2017
The major structural components of the nuclear lamina are the Type V intermediate filament proteins, the nuclear lamins. There are four nuclear lamin isoforms (Lamins A, C, B1 and B2), which interact along with their binding partners to form a molecular interface between the inner nuclear envelope membrane and chromatin, the nuclear lamina in mammalian
Robert Goldman, Stephen A. Adam, Anne E. Goldman, Takeshi Shimi, Mark Kittisopikul, Khuloud Jaqaman, Yagmur Turgay, Ohad Medalia   +7 more
openaire   +1 more source

Nuclear Lamins: Laminopathies and Their Role in Premature Ageing

Physiological Reviews, 2006
It has been demonstrated that nuclear lamins are important proteins in maintaining cellular as well as nuclear integrity, and in maintaining chromatin organization in the nucleus. Moreover, there is growing evidence that lamins play a prominent role in transcriptional control.
Broers, J.L.V., Ramaekers, F.C.S., Bonne, G., Yaou, R., Hutchison, C.J.   +4 more
openaire   +3 more sources

The structure and function of the nuclear lamins

Proceedings, annual meeting, Electron Microscopy Society of America, 1995
The nuclear lamins are the Type V intermediate filament proteins comprising the nuclear lamina. The lamina is located subjacent to the nucleoplasmic face of the nuclear envelope where it interfaces with chromatin. The lamins are major karyoskeletal proteins which are thought to play important roles in the formation and maintenance of nuclear shape and ...
R.D. Goldman, A. Goldman, S. Khuon, M. Montag-Lowy, R. Moir, T. Spann   +5 more
openaire   +1 more source

The nuclear lamins

Experimental Cell Research, 1986
Georg Krohne, Ricardo Benavente
openaire   +1 more source

Posttranslational Processing of Nuclear Lamins

2011
Publisher Summary This chapter reviews the posttranslational processing of the nuclear lamins and discusses its importance to health and disease. The nuclear lamina, a meshwork formed from intermediate filament proteins, provides structural scaffolding for the cell nucleus. The principal proteins of the nuclear lamina are lamin A, lamin B1, lamin B2,
openaire   +1 more source

The Nuclear Lamins: Flexibility in Function

Nature Reviews Molecular Cell Biology, 2013
Colin L Stewart, Brian Burke
exaly  

Lamins: Nuclear Intermediate Filament Proteins With Fundamental Functions in Nuclear Mechanics and Genome Regulation

Annual Review of Biochemistry, 2015
Yosef Gruenbaum, Roland Foisner
exaly