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Lamins as structural nuclear elements through evolution
Current Opinion in Cell Biology, 2023Lamins are nuclear intermediate filament proteins with important, well-established roles in humans and other vertebrates. Lamins interact with DNA and numerous proteins at the nuclear envelope to determine the mechanical properties of the nucleus, coordinate chromatin organization, and modulate gene expression.
Jacob Odell, Jan Lammerding
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Autoantibodies to Nuclear Lamins
Annals of Internal Medicine, 1988Excerpt In this issue, Lassoued and colleagues (1) describe findings related to the presence of autoantibodies to lamin proteins B, A, and C in a heterogeneous group of patients with thrombocytopen...
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Interaction between Emerin and Nuclear Lamins
Journal of Biochemistry, 2001Emerin is an inner nuclear membrane protein that is involved in X-linked recessive Emery-Dreifuss muscular dystrophy (X-EDMD). Although the function of this protein is still unknown, we revealed that C-terminus transmembrane domain-truncated emerin (amino acid 1-225) binds to lamin A with higher affinity than lamin C.
M, Sakaki +6 more
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Mapping Nuclear Lamin-Genome Interactions by Chromatin Immunoprecipitation of Nuclear Lamins
2016The nuclear lamina is a meshwork of A- and B-type lamins which interact with chromatin and regulate many nuclear functions. Recent studies have reported the discovery of chromatin domains interacting with nuclear lamins by chromatin immunoprecipitation (ChIP) of lamin A/C or B1 and identification of the associated DNA sequences by microarray or high ...
Anja R, Oldenburg, Philippe, Collas
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Nuclear Structures Surrounding Internal Lamin Invaginations
Journal of Cellular Biochemistry, 2014ABSTRACTA‐ and C‐type lamins are intermediate filament proteins responsible for the maintenance of nuclear shape and most likely nuclear architecture. Here, we propose that pronounced invaginations of A/C‐type lamins into the nuclear interior represent channels for the transport of regulatory molecules to and from nuclear and nucleolar regions.
Soňa, Legartová +5 more
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Scaffold, mechanics and functions of nuclear lamins
FEBS Letters, 2023Nuclear lamins are type‐V intermediate filaments that are involved in many nuclear processes. In mammals, A‐ and B‐type lamins assemble into separate physical meshwork underneath the inner nuclear membrane, the nuclear lamina, with some residual fraction localized within the nucleoplasm.
Buxboim, Amnon +6 more
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Functions of the nuclear lamins
Protoplasma, 2000The nuclear lamina is a filamentous structure, composed of lamins, that supports the inner nuclear membrane. Several integral membrane proteins including LBR (lamin B receptor), LAP (lamin-associated polypeptide) 1, and LAP 2 bind nuclear lamins in vitro and may influence lamin function and dynamics in vivo.
O. A. Vaughan +2 more
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Redistribution of nuclear lamins in mitotic cells
Biology of the Cell, 1986The nuclear lamins are directed from the cytoplasm to chromosomes as part of the maturation pathway of the interphase nucleoskeleton. In mitosis, the three polypeptides lamin A, B and C were found in the cytoplasm from prophase until anaphase and shifted to chromosomal surfaces at telophase (Ely, D'Arcy and Jost, 1978; Gerace, Blum and Blobel, 1978 ...
E, Jost +4 more
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Nuclear Lamin for Gene Silencing
Science Signaling, 2008In the Drosophila ovary, germline stem cells (GSCs) divide to produce one cell that differentiates (a cystoblast) and one stem cell. The stem cell population is maintained by the release of Decapentaplegic (Dpp, a member of the bone morphogenetic protein family) from the stromal somatic cap cells (niche cells ...
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Nuclear Lamins in Mammalian Spermatogenesis
2010Nuclear lamins are important structural protein components of the nuclear envelope. The composition and properties of the nuclear lamina of spermatogenic cells differ significantly from those of somatic cells of the same species. Mammalian spermatogenic cells selectively express short lamin isoforms showing several peculiarities.
Manfred Alsheimer +3 more
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