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The nuclear lamins: flexibility in function

Nature Reviews Molecular Cell Biology, 2012
The nuclear lamina is an important structural determinant for the nuclear envelope as a whole, attaching chromatin domains to the nuclear periphery and localizing some nuclear envelope proteins. The major components of the lamina are the A-type and B-type lamins, which are members of the intermediate filament protein family. Whereas the expression of A-
Brian, Burke, Colin L, Stewart
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Nuclear Lamins: Thin Filaments with Major Functions

Trends in Cell Biology, 2018
The nuclear lamina is a nuclear peripheral meshwork that is mainly composed of nuclear lamins, although a small fraction of lamins also localizes throughout the nucleoplasm. Lamins are classified as type V intermediate filament (IF) proteins. Mutations in lamin genes cause at least 15 distinct human diseases, collectively termed laminopathies ...
de Leeuw, Rebecca   +2 more
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Nuclear Lamins: Their Structure, Assembly, and Interactions

Journal of Structural Biology, 1998
Nuclear lamins are intermediate filament-type proteins that are the major building blocks of the nuclear lamina, a fibrous proteinaceous meshwork underlying the inner nuclear membrane. Lamins can also be localized in the nuclear interior, in a diffuse or spotted pattern.
N, Stuurman, S, Heins, U, Aebi
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Nuclear lamins

Neurology, 2012
ADLD= : adult-onset autosomal dominant leukodystrophy; CMT= : Charcot-Marie-Tooth; EDMD= : Emery-Dreifuss muscular dystrophy; LAP= : lamin-associated polypeptide; LBR= : lamin B receptor; LGMD1B= : autosomal dominant limb-girdle muscular dystrophy The nuclear envelope is the interface between the nucleus and the rest of the cell and ...
CORTELLI, PIETRO   +3 more
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The nuclear envelope, lamins and nuclear assembly

Current Opinion in Cell Biology, 2002
The nuclear lamina is composed of both A- and B-type lamins and lamin-binding proteins. Many lamin-binding proteins are integral proteins of the inner nuclear membrane. Lamins and inner nuclear membrane proteins are important for a variety of cell functions, including nuclear assembly, replication, transcription, and nuclear integrity.
James M, Holaska   +2 more
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Nuclear lamins, diseases and aging

Current Opinion in Cell Biology, 2006
Nuclear lamins are type V intermediate filament proteins. They are the major building blocks of the peripheral nuclear lamina, a complex meshwork of proteins underlying the inner nuclear membrane. In addition to providing nuclear shape and mechanical stability, they are required for chromatin organization, transcription regulation, DNA replication ...
Anna, Mattout   +4 more
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Nuclear lamins

1999
Abstract The nuclear lamins are intermediate filament proteins that are found exclusively in the cell nucleus of most multicellular animals and probably plants. The lamins assemble to form the nuclear lamina at the nuclear periphery. There also appear to be lamin assemblies within the nucleus. The lamins have been implicated as the major
Robert D Moir   +2 more
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