Results 201 to 210 of about 1,480,665 (235)
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The Nuclear Envelope, Lamins and Nuclear Assembly
Current Opinion in Cell Biology, 2002The nuclear lamina is composed of both A- and B-type lamins and lamin-binding proteins. Many lamin-binding proteins are integral proteins of the inner nuclear membrane. Lamins and inner nuclear membrane proteins are important for a variety of cell functions, including nuclear assembly, replication, transcription, and nuclear integrity.
James M Holaska
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Neurology, 2012
ADLD= : adult-onset autosomal dominant leukodystrophy; CMT= : Charcot-Marie-Tooth; EDMD= : Emery-Dreifuss muscular dystrophy; LAP= : lamin-associated polypeptide; LBR= : lamin B receptor; LGMD1B= : autosomal dominant limb-girdle muscular dystrophy The nuclear envelope is the interface between the nucleus and the rest of the cell and ...
CORTELLI, PIETRO +3 more
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ADLD= : adult-onset autosomal dominant leukodystrophy; CMT= : Charcot-Marie-Tooth; EDMD= : Emery-Dreifuss muscular dystrophy; LAP= : lamin-associated polypeptide; LBR= : lamin B receptor; LGMD1B= : autosomal dominant limb-girdle muscular dystrophy The nuclear envelope is the interface between the nucleus and the rest of the cell and ...
CORTELLI, PIETRO +3 more
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The nuclear lamins: flexibility in function
Nature Reviews Molecular Cell Biology, 2012The nuclear lamina is an important structural determinant for the nuclear envelope as a whole, attaching chromatin domains to the nuclear periphery and localizing some nuclear envelope proteins. The major components of the lamina are the A-type and B-type lamins, which are members of the intermediate filament protein family. Whereas the expression of A-
Brian, Burke, Colin L, Stewart
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Nuclear lamins, diseases and aging
Current Opinion in Cell Biology, 2006Nuclear lamins are type V intermediate filament proteins. They are the major building blocks of the peripheral nuclear lamina, a complex meshwork of proteins underlying the inner nuclear membrane. In addition to providing nuclear shape and mechanical stability, they are required for chromatin organization, transcription regulation, DNA replication ...
Anna, Mattout +4 more
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The Conserved Carboxy-Terminal Cysteine of Nuclear Lamins Is Essential for Lamin Association With the Nuclear Envelope. [PDF]
Journal of Cell Biology, 1989 We have analyzed the interaction of soluble nuclear lamins with the nuclear envelope by microinjection of normal and mutated lamins into the cytoplasm of Xenopus laevis oocytes. Our results demonstrate that the conserved cysteine of the carboxy-terminal tetrapeptide Cys Ala/Ser Ile Met of lamins is essential for their association with the nuclear ...
Georg Krohne
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Identification of Distinct Messenger RNAs for Nuclear Lamin C and a Putative Precursor of Nuclear Lamin A. [PDF]
Journal of Cell Biology, 1984 The lamins are the major components of the nuclear matrix and are known as lamins A, B, and C with Mr 72,000, 68,000, and 62,000 when analysed by SDS PAGE. These three polypeptides are very similar, as determined by polypeptide mapping and immunological reactivity. Lamins A and C are so homologous that a precursor-product relationship has been proposed.
V Bibor-Hardy, R Simard, M Filion
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Autoantibodies to Nuclear Lamins
Annals of Internal Medicine, 1988Excerpt In this issue, Lassoued and colleagues (1) describe findings related to the presence of autoantibodies to lamin proteins B, A, and C in a heterogeneous group of patients with thrombocytopen...
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1999
Abstract The nuclear lamins are intermediate filament proteins that are found exclusively in the cell nucleus of most multicellular animals and probably plants. The lamins assemble to form the nuclear lamina at the nuclear periphery. There also appear to be lamin assemblies within the nucleus. The lamins have been implicated as the major
Robert D Moir +2 more
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Abstract The nuclear lamins are intermediate filament proteins that are found exclusively in the cell nucleus of most multicellular animals and probably plants. The lamins assemble to form the nuclear lamina at the nuclear periphery. There also appear to be lamin assemblies within the nucleus. The lamins have been implicated as the major
Robert D Moir +2 more
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Mapping Nuclear Lamin-Genome Interactions by Chromatin Immunoprecipitation of Nuclear Lamins
2016The nuclear lamina is a meshwork of A- and B-type lamins which interact with chromatin and regulate many nuclear functions. Recent studies have reported the discovery of chromatin domains interacting with nuclear lamins by chromatin immunoprecipitation (ChIP) of lamin A/C or B1 and identification of the associated DNA sequences by microarray or high ...
Anja R, Oldenburg, Philippe, Collas
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Role of Nuclear Lamins in Nuclear Organization, Cellular Signaling, and Inherited Diseases
International Review of Cell and Molecular Biology, 2008 Lamins are the major architectural proteins of the nucleus and are essential for nuclear integrity and assembly. Lamins are also involved in the organization of nuclear functions such as DNA replication, transcription, and repair.
Veena Parnaik
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