Viruses, 2023 Replication of the RNA genome of influenza A virus occurs in the nucleus of infected cells. The influenza nucleoprotein (NP) associated with the viral RNA into ribonucleoprotein complexes (vRNPs) is involved in the nuclear import of the viral genome.
Nhan L. T. Nguyen, Wei Wu, Nelly Panté
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Nuclear import: A tale of two sites [PDF]
, 1998 The recently determined crystal structure of a nuclear localization sequence receptor has revealed an exquisitely specific interaction between ligand and receptor, and explains how simple and complex nuclear localization signals can both be recognized ...
Dingwall, Colin, Laskey, Ronald A
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Characterization of a nuclear localization signal in the foot-and-mouth disease virus polymerase [PDF]
, 2013 We have experimentally tested whether the MRKTKLAPT sequence in FMDV 3D protein (residues 16 to 24) can act as a nuclear localization signal (NLS). Mutants with substitutions in two basic residues within this sequence, K18E and K20E, were generated.
Rosas, Maria Flora +2 more
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Identification of a Bipartite Nuclear Localization Sequence Necessary for Nuclear Import of 5-Lipoxygenase [PDF]
Journal of Biological Chemistry, 1999 5-Lipoxygenase catalyzes the synthesis of leukotrienes from arachidonic acid. This enzyme can reside either in the cytoplasm or the nucleus; its subcellular distribution is influenced by extracellular factors, and its nuclear import correlates with changes in leukotriene synthetic capacity.
Ji Ping Yao +3 more
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Muscovy duck reovirus p10.8 protein localizes to the nucleus via a nonconventional nuclear localization signal [PDF]
, 2014 BACKGROUND: It was previously report that the first open reading frame of Muscovy duck reocvirus S4 gene encodes a 95-amino-acid protein, designed p10.8, which has no sequence similarity to other known proteins.
Dongchun Guo +8 more
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The Nuclear Localization of Glycogen Synthase Kinase 3β Is Required Its Putative PY-Nuclear Localization Sequences [PDF]
Molecules and Cells, 2012 Glycogen synthase kinase-3β(GSK-3β), which is a member of the serine/threonine kinase family, has been shown to be crucial for cellular survival, differentiation, and metabolism. Here, we present evidence that GSK-3β is associated with the karyopherin β2 (Kap β2) (102-kDa), which functions as a substrate for transportation into the nucleus. A potential
Sunghee Hyun +5 more
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Diffusion of Proteins Across the Nuclear Envelope of HeLa Cells
BioTechniques, 1998 We describe an experimental system to study nucleocytoplasmic diffusion of proteins in living HeLa cells. To localize proteins to the nucleus, substrates were created that contain a nuclear localization sequence fused to Aequorea victoria green ...
Shivani Chatterjee, Ursula Stochaj
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The Ebola Virus Interferon Antagonist VP24 Undergoes Active Nucleocytoplasmic Trafficking
Viruses, 2021 Viral interferon (IFN) antagonist proteins mediate evasion of IFN-mediated innate immunity and are often multifunctional, with distinct roles in viral replication.
Angela R. Harrison +3 more
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Enhancing the cellular uptake of Py–Im polyamides through next-generation aryl turns [PDF]
, 2012 Pyrrole–imidazole (Py–Im) hairpin polyamides are a class of programmable, sequence-specific DNA binding oligomers capable of disrupting protein–DNA interactions and modulating gene expression in living cells.
Baird +54 more
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Nuclear Targeting of the Maize R Protein Requires Two Nuclear Localization Sequences [PDF]
Plant Physiology, 1993 Previous genetic and structural evidence indicates that the maize R gene encodes a nuclear transcriptional activating factor. In-frame carboxyl- and amino-terminal fusions of the R gene to the reporter gene encoding beta-glucuronidase (GUS) were sufficient to direct GUS to the nucleus of the transiently transformed onion (Allium cepa) epidermal cells ...
Susan R. Wessler +2 more
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