Results 61 to 70 of about 709,714 (368)

Dual Requirement for Yeast hnRNP Nab2p in mRNA poly(A) Tail Length Control and Nuclear Export [PDF]

, 2002
Recent studies of mRNA export factors have provided additional evidence for a mechanistic link between mRNA 3′‐end formation and nuclear export. Here, we identify Nab2p as a nuclear poly(A)‐binding protein required for both poly(A) tail length control ...
Anderson, James T., Dheur, Sonia, Hector, Ronald E., Minvielle‐Sebastia, Lionel, Non, Priscilla J., Nykamp, Keith R., Swanson, Maurice S., Urbinati, Carl R., Wilson, Scott M.   +8 more
core   +3 more sources

Differential Expression and Sequence-specific Interaction of Karyopherin α with Nuclear Localization Sequences [PDF]

Journal of Biological Chemistry, 1997
The process of nuclear protein transport requires the interaction of several different proteins, either directly or indirectly with nuclear localization or targeting sequences (NLS). Recently, a number of karyopherins alpha, or NLS-binding proteins, have been identified.
Douglas Tritschler, Steven G. Nadler, Jeffrey S. Cleaveland, Omar K. Haffar, Bruce A Gregory, James Blake   +5 more
openaire   +2 more sources

Different domains cooperate to target the human ribosomal L7a protein to the nucleus and to the nucleoli. [PDF]

, 1997
The human ribosomal protein L7a is a component of the major ribosomal subunit. We transiently expressed in HeLa cells L7a-β-galactosidase fusion proteins and studied their subcellular localization by indirect immunofluorescence staining with anti-β ...
Giulia RUSSO, PIETROPAOLO C., RICCIARDELLI G.   +2 more
core   +1 more source

Structural basis of nuclear import of flap endonuclease 1 (FEN1) [PDF]

, 2012
Flap endonuclease 1 (FEN1) is a member of the nuclease family and is structurally conserved from bacteriophages to humans. This protein is involved in multiple DNA-processing pathways, including Okazaki fragment maturation, stalled replication-fork ...
Agnes A. S. Takeda, Andrea C. de Barros, Bertinato, Boštjan Kobe, Catimel, Chelsky, Chen, Chiung-Wen Chang, Colledge, Conti, Cutress, Dingwall, Efthymiadis, Emsley, Fontes, Fontes, Fontes, Görlich, Hodel, Hosfield, Hu, Hwang, Hübner, Knudsen, Kobe, Koike, Koike, Kosugi, Kosugi, Laskowski, Lott, Marcos R. M. Fontes, Marfori, Mase, Miyamoto, Murshudov, Otwinowski, Qiu, Rexach, Sakurai, Studier, Takeda, Teh, Tsutakawa, Wallace, Yang, Zheng   +46 more
core   +2 more sources

Inhibition of Nuclear Translocation of Transcription Factor NF-κB by a Synthetic Peptide Containing a Cell Membrane-permeable Motif and Nuclear Localization Sequence (*)

Journal of Biological Chemistry, 1995
To control agonist-induced nuclear translocation of transcription factor κB (NF-κB) in intact cells, cell-permeable synthetic peptides were devised. Their import into intact cells was dependent on a hydrophobic region selected from the signal peptide ...
Yao-Zhong Lin, SongYi Yao, R. Veach, T. Torgerson, J. Hawiger   +4 more
semanticscholar   +1 more source

Investigation of latent nuclear localization sequence(NLS) OF STAT3 [PDF]

Chinese Journal of Cancer Research, 2004
Objective: To investigate the latent nuclear localization sequence (NLS) OF STAT3. Methods: Clustal X (1.81) was used to alignment the DNA binding domain of the STAT family. According to structure characters, corresponding expression plasmids were constructed via oligonucleotides designed with gene tool software.
Li Hui, Yang Zhen-hui, Shen Beifen, Ye Zhong-de, Feng Jiannan   +4 more
openaire   +1 more source

Identification of Nuclear Localization Signals in the ORF2 Protein of Porcine Circovirus Type 3

Viruses, 2019
Porcine circovirus type 3 (PCV3) contains two major open reading frames (ORFs) and the ORF2 gene encodes the major structural capsid protein. In this study, nuclear localization of ORF2 was demonstrated by fluorescence observation and subcellular ...
Chunxiao Mou, Minmin Wang, Shuonan Pan, Zhenhai Chen   +3 more
doaj   +1 more source

Targeting Nuclear Import Shuttles, Importins/Karyopherins alpha by a Peptide Mimicking the NFκB1/p50 Nuclear Localization Sequence

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2013
Background We recently reported that a bifunctional nuclear transport modifier (NTM), cSN50.1 peptide, reduced atherosclerosis, plasma cholesterol, triglycerides, and glucose along with liver fat and inflammatory markers, in a murine model of familial ...
J. Zienkiewicz, Amy Armitage, J. Hawiger
semanticscholar   +1 more source

Cytoplasmic localization of calcium/calmodulin-dependent protein kinase I-α depends on a nuclear export signal in its regulatory domain [PDF]

, 2004
Calcium/calmodulin-dependent protein kinase I-α (CaMKI-α) is a ubiquitous cytosolic enzyme that phosphorylates a number of nuclear proteins in vitro and has been implicated in transcriptional regulation. We report that cytoplasmic localization of CaMKI-α
Ahmed, Cabot, Clapperton, Condon, Fornerod, Gardner, Goldberg, Hanks, Henderson, Ishikawa, Jans, Joseph, Kahl, Kimura, Komeili, la Cour, Lee, Lemrow, McKinsey, Nairn, Nakamura, Nishimura, Picciotto, Picciotto, Qin, Rasmussen, Saneyoshi, Sheng, Soderling, Suizu, Sun, Susilowati, Takemoto-Kimura, Ueda, Verploegen, Wayman, Yokokura   +36 more
core   +1 more source

Identification of a Nuclear Localization Sequence in β-Arrestin-1 and Its Functional Implications*

Journal of Biological Chemistry, 2012
Background: β-Arrestin-1 is present in the nucleus but lacks an identifiable nuclear localization signal. Results: Using sequence comparison and mutagenesis, we found Lys157 is critical to β-arrestin-1 nuclear localization and its regulation of NF-κB ...
C. Z. Hoeppner, Ni Cheng, R. Ye
semanticscholar   +1 more source