Results 211 to 220 of about 225,091 (245)
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Factors influencing the nuclear targeting ability of nuclear localization signals
Journal of Drug Targeting, 2016A nuclear localization signal (NLS) is a short amino acid sequence derived from eukaryotic nuclear proteins and viral proteins. Many NLS peptides can efficiently mediate the intranucleus transport of cargo molecules, so they have been widely used for non-viral gene transfer and shown potential ability to improve nuclear delivery of DNA.
Pingtian Ding, Yanping Sun
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Nuclear localization signals in trypanosomal proteins
Molecular and Biochemical Parasitology, 2019The nuclear import of proteins in eukaryotic cells is a fundamental biological process. While it has been analysed to different extents in model eukaryotic organisms, this event has rarely been studied in the early divergent protozoa of the order Kinetoplastida. The work presented here represents an overview of nuclear import in these important species
Israel Canela-Pérez +4 more
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Nuclear localization signals and human disease
IUBMB Life, 2009AbstractIn eukaryotic cells, the physical separation of the genetic material in the nucleus from the translation and signaling machinery in the cytoplasm by the nuclear envelope creates a requirement for a mechanism through which macromolecules can enter or exit the nucleus as necessary.
Laura M, McLane, Anita H, Corbett
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Synthetic peptides as nuclear localization signals
Nature, 1986The nuclear envelope defines a compartment boundary which is penetrated by pores that mediate a remarkable transport process. Precursor RNAs are retained in the nucleus, while processed messenger RNA, transfer RNA and ribosomal subunits are transported to the cytoplasm.
D S, Goldfarb +3 more
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Nuclear Localization Signals of the BRCA2 Protein
Biochemical and Biophysical Research Communications, 2000BRCA2 is a tumor suppressor gene whose germline mutations increase the lifetime risk of breast cancer. BRCA2 encodes a large nuclear protein involved in DNA repair, but the location of its functional domain has been unclear. Here, we report nuclear localization signals (NLSs) of the BRCA2 protein.
K, Yano +5 more
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Can Nuclear Localization Signals Enhance Nuclear Localization of Plasmid DNA?
Bioconjugate Chemistry, 2003Nonviral vectors are safer and more cost-effective than viral vectors but are significantly less efficient, and thus, increasing the efficiency of nonviral vectors remains an important objective. One way to overcome this problem is by stimulating the nuclear localization of exogenous genes.
Takeshi, Nagasaki +4 more
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Biochemical Journal, 2002
5-Lipoxygenase (5-LO) metabolizes arachidonic acid to leukotriene A4, a key intermediate in leukotriene biosynthesis. To explore the molecular mechanisms of its cell-specific localization, a fusion protein between green fluorescent protein (GFP) and human 5-LO (GFP—5LO) was expressed in various cells. GFP—5LO was localized in the cytosol in HL-60 cells
Hiromi, Hanaka +2 more
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5-Lipoxygenase (5-LO) metabolizes arachidonic acid to leukotriene A4, a key intermediate in leukotriene biosynthesis. To explore the molecular mechanisms of its cell-specific localization, a fusion protein between green fluorescent protein (GFP) and human 5-LO (GFP—5LO) was expressed in various cells. GFP—5LO was localized in the cytosol in HL-60 cells
Hiromi, Hanaka +2 more
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Gli Protein Nuclear Localization Signal
2012Drosophila cubitus interruptus (Ci) and its vertebrate homologues, the glioblastoma (Gli) protein family, are the transcription factors belonging to the metazoan Gli/Glis/Zic ZF protein superfamily that shares similar five tandemly repeated C2H2-type zinc finger (ZF) motifs.
Minoru, Hatayama, Jun, Aruga
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Search for a Nuclear Localization Signal in the Prion Protein
Molecular and Cellular Neuroscience, 1998Spongiform transmissible encephalopathies are neurodegenerative diseases characterized by the accumulation, in infected brains, of a pathological form of a normal host-encoded protein called PrP. Previous data have shown that PrP could interact with cytosolic factors, including nuclear molecules, emphasizing the possible function of such interactions ...
A, Jaegly +5 more
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Simple Mimetics of a Nuclear Localization Signal (NLS)
Organic Letters, 2003[reaction: see text] Molecular modeling was used to design mimetics of the HIV-1 matrix protein nuclear localization signal (NLS) in which a scaffold of two resorcinol units joined by a diamide linker presents 3-aminopropyl ethers in place of lysine side chains. Prospective mimetics with linkers of 6, 8, 10, or 12 atoms were synthesized and compared in
Seung Bum, Park +4 more
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