Results 221 to 230 of about 225,091 (245)

Multiple nuclear localization signals in XPG nuclease

Mutation Research/DNA Repair, 1996
We report here evidence for the mechanism of nuclear localization of XPG nuclease in human cells. Several candidate nuclear localization signal (NLS) peptides have been proposed for XPG protein. We have identified XPG peptides containing functional NLS and a potential nuclear retention signal (NRS) using in situ immunofluorescene localization of ...
J A, Knauf, S H, Pendergrass, B L, Marrone, G F, Strniste, M A, MacInnes, M S, Park   +5 more
openaire   +2 more sources

Identification of a nuclear localization signal in suppressor of cytokine signaling 1

The FASEB Journal, 2008
Suppressor of cytokine signaling (SOCS) proteins are inducible feedback inhibitors of janus kinase and signal transducer and activators of transcription signaling pathways. In addition, SOCS1 has been identified to regulate stability of nuclear NF‐ΚB subunits.
Andrea, Baetz, Christian, Koelsche, Julia, Strebovsky, Klaus, Heeg, Alexander H, Dalpke   +4 more
openaire   +2 more sources

Coupling of Nuclear Localization Signals to Plasmid DNA

2003
This chapter focuses on a methodology for covalently associating nuclear localization signal (NLS) peptides to DNA, in which cationic NLS peptides are covalently bound to plasmid DNA by photoactivation. Described here are the synthesis and characterization of these conjugates.
C, Neves, D, Scherman, P, Wils
openaire   +2 more sources

Regulation of subcellular localization of the antiproliferative protein Tob by its nuclear export signal and bipartite nuclear localization signal sequences

Experimental Cell Research, 2004
Tob, a member of the Tob and BTG antiproliferative protein family, plays an important role in many cellular processes including cell proliferation. In this study, we have addressed molecular mechanisms regulating subcellular localization of Tob. Treatment with leptomycin B, an inhibitor of nuclear export signal (NES) receptor, resulted in a change in ...
Momoko, Maekawa, Takuya, Yamamoto, Eisuke, Nishida   +2 more
openaire   +2 more sources

Optimization of nuclear localization signal for nuclear transport of DNA-encapsulating particles

Journal of Controlled Release, 2005
The nuclear membrane is a tight barrier against the delivery of therapeutic genes into non-dividing tissue cells. Overcoming this barrier with the aid of peptidic nuclear localization signals (NLS) is crucial for improving the performance of synthetic gene-delivery vehicles.
Akiko Eguchi, Hiroyuki Furusawa, Akitsugu Yamamoto, Teruo Akuta, Mamoru Hasegawa, YOSHIO OKAHATA, Mahito Nakanishi   +6 more
openaire   +2 more sources

Nuclear localization and signalling activity of inositol lipids.

Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia, 2001
It has been recently shown that also the nucleus is a site for both synthesis and hydrolysis of the phosphorylated forms of phosphatidylinositol. Among the enzymes of the cycle we and others have demonstrated that phospholipase C specific for inositol lipids (PLC) is one of the main steps of the inositol lipid cycle.
COCCO L, MARALDI NM, CAPITANI, Silvano, MARTELLI AM, MANZOLI FA   +4 more
openaire   +2 more sources

Nuclear localization signals (NLS).

Critical reviews in eukaryotic gene expression, 1993
Available data strongly suggest that simple karyophilic clusters of arginines and lysines in nucleus-targeted proteins signal the anchoring of these proteins to specialized transporter molecules found on the pore complex or in the cytoplasm. These peptides have been termed nuclear localization signals (NLS).
openaire   +1 more source

Understanding the impact of nuclear-localized GPCRs on cellular signalling

Cellular Signalling
G protein-coupled receptors (GPCRs) have historically been associated with signalling events driven from the plasma membrane. More recently, signalling from endosomes has been recognized as a feature of internalizing receptors. However, there was little consideration given to the notion that GPCRs can be targeted to distinct subcellular locations that ...
Bruce G, Allen, Clémence, Merlen, Ana F, Branco, Darlaine, Pétrin, Terence E, Hébert   +4 more
openaire   +2 more sources

More than a zip code: global modulation of cellular function by nuclear localization signals

FEBS Journal, 2021
Chih-Chia Chang, Kuo-Chiang Hsia
exaly  

Nuclear Localization Signal

2008
openaire   +2 more sources