Results 241 to 250 of about 805,782 (407)

Structural interaction between the nuclear pore complex and a specific translocating RNP particle. [PDF]

, 1995
Hans Mehlin, Bertil Daneholt, Ulf Skoglund   +2 more
openalex   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Revealing mechanism of pore defect formation in laser directed energy deposition of aluminum alloy via in-situ synchrotron X-ray imaging [PDF]

arXiv
Laser metal additive manufacturing technology is capable of producing components with complex geometries and compositions that cannot be realized by conventional manufacturing methods. However, a large number of pores generated during the additive manufacturing process greatly affect the mechanical properties of the additively manufactured parts, and ...
arxiv  

Unveiling the complexity: assessing models describing the structure and function of the nuclear pore complex. [PDF]

Front Cell Dev Biol, 2023
Rush C, Jiang Z, Tingey M, Feng F, Yang W.   +4 more
europepmc   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Structure and Function of the Nuclear Pore Complex. [PDF]

Cold Spring Harb Perspect Biol, 2022
Petrovic S, Mobbs GW, Bley CJ, Nie S, Patke A, Hoelz A.   +5 more
europepmc   +1 more source

Essential Roles forCaenorhabditis elegansLamin Gene in Nuclear Organization, Cell Cycle Progression, and Spatial Organization of Nuclear Pore Complexes [PDF]

, 2000
Jun Liu, Tom Rolef Ben-Shahar, Dieter Riemer, Millet Treinin, P. Spann, Klaus Weber, Andrew Fire, Yosef Gruenbaum   +7 more
openalex   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

The Fractal Blueprint: Soil Pores, Symmetry, and Climate Mitigation [PDF]

arXiv
Soil is a critical component of terrestrial ecosystems, directly influencing global biogeochemical cycles. Despite its importance, the complex architecture of soil pores and their impact on greenhouse gas emissions remain poorly understood. This perspective aims to address this gap by applying discrete symmetry and symmetry-breaking concepts through ...
arxiv  

The Matrix Protein of Vesicular Stomatitis Virus Inhibits Nucleocytoplasmic Transport When It Is in the Nucleus and Associated with Nuclear Pore Complexes [PDF]

, 2000
Jeannine M. Petersen, Lu-Shuin Her, Virgil E. Varvel, Elsebet Lund, James E. Dahlberg   +4 more
openalex   +1 more source