Results 241 to 250 of about 294,484 (344)

Protein Transport by the Nuclear Pore Complex: Simple Biophysics of a Complex Biomachine.

Biophysical Journal, 2017
T. Jovanović-Talisman, A. Zilman
semanticscholar   +1 more source

Docking a flexible basket onto the core of the nuclear pore complex. [PDF]

Nat Cell Biol
Stankunas E, Köhler A.
europepmc   +1 more source

Figure S6 from Defining the Antitumor Mechanism of Action of a Clinical-stage Compound as a Selective Degrader of the Nuclear Pore Complex [PDF]

Linjie Yuan, Wenzhi Ji, Brendan G. Dwyer, Joey Lu, Jing Bian, Gianna M. Colombo, Michael J. Martinez, Daniel Fernández, Nick A. Phillips, Michelle T. Tang, Wenjie Zhou, Nirk E. Quispe Calla, Cesar Guzman Huancas, Michael Eckart, Jessica Tran, Hannah M. Jones, Tian Qiu, John G. Doench, Matthew G. Rees, Jennifer A. Roth, Michael D. Cameron, Gregory W. Charville, Calvin J. Kuo, Scott J. Dixon, Tinghu Zhang, Stephen M. Hinshaw, Nathanael S. Gray, Steven M. Corsello   +27 more
openalex   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

TorsinA is essential for neuronal nuclear pore complex localization and maturation. [PDF]

Nat Cell Biol
Kim S, Phan S, Tran HT, Shaw TR, Shahmoradian SH, Ellisman MH, Veatch SL, Barmada SJ, Pappas SS, Dauer WT.   +9 more
europepmc   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

A Small Ubiquitin-Related Polypeptide Involved in Targeting RanGAP1 to Nuclear Pore Complex Protein RanBP2

Cell, 1997
Rohit Mahajan, C. Delphin, T. Guan, L. Gerace, F. Melchior   +4 more
semanticscholar   +1 more source

Targeting colorectal cancer at the level of nuclear pore complex. [PDF]

J Adv Res
Khakwani MMAK, Ji XY, Khattak S, Sun YC, Yao K, Zhang L.   +5 more
europepmc   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Slide-and-exchange mechanism for rapid and selective transport through the nuclear pore complex

Proceedings of the National Academy of Sciences of the United States of America, 2016
Barak Raveh, J. Karp, Samuel E. Sparks, K. Dutta, M. Rout, A. Sali, D. Cowburn   +6 more
semanticscholar   +1 more source