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Nuclear pores. Architecture of the nuclear pore complex coat.
Science (New York, N.Y.), 2015The nuclear pore complex (NPC) constitutes the sole gateway for bidirectional nucleocytoplasmic transport. Despite half a century of structural characterization, the architecture of the NPC remains unknown. Here we present the crystal structure of a reconstituted ~400-kilodalton coat nucleoporin complex (CNC) from Saccharomyces cerevisiae at a 7.4 ...
Tobias, Stuwe +6 more
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2010
Nuclear pore complexes (NPCs) are large macromolecular assemblies with an estimated mass of about 125 million Dalton. Depending on the activity of a cell, the number of NPCs varies but is usually around 3000–4000 per nucleus. NPCs are sites of bidirectional transport.
Margit Pavelka, Jürgen Roth
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Nuclear pore complexes (NPCs) are large macromolecular assemblies with an estimated mass of about 125 million Dalton. Depending on the activity of a cell, the number of NPCs varies but is usually around 3000–4000 per nucleus. NPCs are sites of bidirectional transport.
Margit Pavelka, Jürgen Roth
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Pore relations: nuclear pore complexes and nucleocytoplasmic exchange
Essays in Biochemistry, 2000NPCs are the sole sites of exchange between the nucleus and cytoplasm. A large family of transport factors carry cargo between the nucleus and cytoplasm through the NPC. The NPC is a huge symmetric octagonal structure comprised of dozens of NUPs. NUPs make many contacts with surrounding structures, including the NE, the cytoplasm and nuclear interior ...
M P, Rout, J D, Aitchison
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Nuclear pore complexes: Round the bend?
Nature Cell Biology, 2005Nuclear pore complexes intuitively seem functionally analogous to transmembrane channels. Recent bioinformatic analysis, however, suggests a quite different evolutionary relationship: one between nuclear pore complexes and vesicle coat components. This has led to the provocative hypothesis that these distinct structures share a common role in bending ...
Wolfram, Antonin, Iain W, Mattaj
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Active genes at the nuclear pore complex
Current Opinion in Cell Biology, 2007The nucleus is spatially and functionally organized and its architecture is now seen as a key contributor to genome functions. A central component of this architecture is the nuclear envelope, which is studded with nuclear pore complexes that serve as gateways for communication between the nucleoplasm and cytoplasm.
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Nuclear pore complexes as clocks of zygotic genome activation
Nature Reviews Molecular Cell Biology, 2023Zlotorynski Eytan, Eytan Zlotorynski
exaly
Comprehensive structure and functional adaptations of the yeast nuclear pore complex
Cell, 2022Ilona Nudelman +2 more
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