Results 241 to 250 of about 258,200 (289)
Some of the next articles are maybe not open access.
Plant Molecular Biology, 1998
The nuclear pore complex is the largest supramolecular complex that assembles in the eukaryotic cell. This structure is highly dynamic and must disassemble prior to mitosis and reassemble after the event. The directed movement of macromolecules into and out of the nucleus occurs through the nuclear pore complex, a potentially regulatory point for ...
A, Heese-Peck, N V, Raikhel
openaire +2 more sources
The nuclear pore complex is the largest supramolecular complex that assembles in the eukaryotic cell. This structure is highly dynamic and must disassemble prior to mitosis and reassemble after the event. The directed movement of macromolecules into and out of the nucleus occurs through the nuclear pore complex, a potentially regulatory point for ...
A, Heese-Peck, N V, Raikhel
openaire +2 more sources
Annual Review of Biochemistry, 1995
The nuclear pore complex (NPC) creates an aqueous channel across the nuclear envelope through which macromolecular transport between nucleus and cytoplasm occurs. Nucleocytoplasmic traffic is bidirectional and involves diverse substrates, including protein and RNA.
openaire +2 more sources
The nuclear pore complex (NPC) creates an aqueous channel across the nuclear envelope through which macromolecular transport between nucleus and cytoplasm occurs. Nucleocytoplasmic traffic is bidirectional and involves diverse substrates, including protein and RNA.
openaire +2 more sources
1996
The nuclear envelope forms the boundary between the nucleus and the cytoplasm and as such regulates the exchange of macromolecules between the two compartments. The channels through the nuclear envelop that actually mediate this macromolecular traffic are the nuclear pore complexes.
R, Bastos, N, Panté, B, Burke
openaire +2 more sources
The nuclear envelope forms the boundary between the nucleus and the cytoplasm and as such regulates the exchange of macromolecules between the two compartments. The channels through the nuclear envelop that actually mediate this macromolecular traffic are the nuclear pore complexes.
R, Bastos, N, Panté, B, Burke
openaire +2 more sources
Pores for thought: nuclear pore complex proteins
Trends in Cell Biology, 1994Nuclear pore complexes (NPCs) are enormous macromolecular structures that mediate the active exchange of proteins and RNPs between the nucleus and cytoplasm. Recent work has resulted in a windfall of identified NPC polypeptides, many with unique sequences.
M P, Rout, S R, Wente
openaire +2 more sources
Nuclear pore complexes feel the strain
Molecular Cell, 2021A cryo-electron tomography structure of the human nuclear pore complex captured in cellulo by Schuller, Wojtynek et al. reveals that nuclear envelope tension expands the central transport channel and imposes asymmetry in the pore membrane.
C Patrick, Lusk, Megan C, King
openaire +2 more sources
Pore relations: nuclear pore complexes and nucleocytoplasmic exchange
Essays in Biochemistry, 2000NPCs are the sole sites of exchange between the nucleus and cytoplasm. A large family of transport factors carry cargo between the nucleus and cytoplasm through the NPC. The NPC is a huge symmetric octagonal structure comprised of dozens of NUPs. NUPs make many contacts with surrounding structures, including the NE, the cytoplasm and nuclear interior ...
M P, Rout, J D, Aitchison
openaire +2 more sources
Poring over chromosomes: mitotic nuclear pore complex segregation
Current Opinion in Cell Biology, 2019Eukaryotic cells rely on flux of macromolecules between the nucleus and the cytoplasm for growth and survival. Bidirectional transport is achieved through Nuclear Pore Complexes (NPCs) embedded in the Nuclear Envelope (NE). NPC proteins perform other cellular functions during mitosis, chromatin organization, DNA repair and gene regulation ...
Subbulakshmi, Suresh, Stephen A, Osmani
openaire +2 more sources
2010
Nuclear pore complexes (NPCs) are large macromolecular assemblies with an estimated mass of about 125 million Dalton. Depending on the activity of a cell, the number of NPCs varies but is usually around 3000–4000 per nucleus. NPCs are sites of bidirectional transport.
Margit Pavelka, Jürgen Roth
openaire +1 more source
Nuclear pore complexes (NPCs) are large macromolecular assemblies with an estimated mass of about 125 million Dalton. Depending on the activity of a cell, the number of NPCs varies but is usually around 3000–4000 per nucleus. NPCs are sites of bidirectional transport.
Margit Pavelka, Jürgen Roth
openaire +1 more source
Selective autophagy degrades nuclear pore complexes
Nature Cell Biology, 2020Nuclear pore complexes (NPCs) are very large proteinaceous assemblies that consist of more than 500 individual proteins1,2. NPCs are essential for nucleocytoplasmic transport of different cellular components, and disruption of the integrity of NPCs has been linked to aging, cancer and neurodegenerative diseases3-7.
Chia-Wei Lee +7 more
openaire +4 more sources
Ran alters nuclear pore complex conformation
Journal of Molecular Biology, 2000Transport across the nuclear membranes occurs through the nuclear pore complex (NPC), and is mediated by soluble transport factors including Ran, a small GTPase that is generally GDP-bound during import and GTP-bound for export. The dynamic nature of the NPC structure suggests a possible active role for it in driving translocation.
Goldberg, MW +7 more
openaire +3 more sources