Results 251 to 260 of about 258,200 (289)
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RanGTP mediates nuclear pore complex assembly
Nature, 2003In metazoa, the nuclear envelope breaks down and reforms during each cell cycle. Nuclear pore complexes (NPCs), which serve as channels for transport between the nucleus and cytoplasm, assemble into the reforming nuclear envelope in a sequential process involving association of a subset of NPC proteins, nucleoporins, with chromatin followed by the ...
Tobias C, Walther +7 more
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Nuclear pore complexes: Round the bend?
Nature Cell Biology, 2005Nuclear pore complexes intuitively seem functionally analogous to transmembrane channels. Recent bioinformatic analysis, however, suggests a quite different evolutionary relationship: one between nuclear pore complexes and vesicle coat components. This has led to the provocative hypothesis that these distinct structures share a common role in bending ...
Wolfram, Antonin, Iain W, Mattaj
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The nuclear pore complex up close
Current Opinion in Cell Biology, 2006Transport between the nucleus and cytoplasm is mediated by nuclear pore complexes (NPCs), perforations in the double-membrane of the nuclear envelope. NPCs are huge protein assemblies made up of distinct subcomplexes. The complex modular nature of the NPC and limitations in the current experimental approaches render the analysis of NPCs and ...
Lim, R. Y. H., Fahrenkrog, B.
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Getting across the nuclear pore complex
Trends in Cell Biology, 1999The nuclear pore complex (NPC) connects the cytoplasm and nucleus through the nuclear envelope and serves as the pipeline for moving material between the two compartments. Macromolecules that move through the NPC range in size from the very small (for example, ions and ATP) to the very large (for example, ribonucleoprotein particle complexes).
B, Talcott, M S, Moore
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Autoantigens of the nuclear pore complex
Journal of Molecular Medicine, 2004The nuclear envelope (NE) is one of many intracellular targets of the autoimmune response in patients with autoimmune liver disease, systemic lupus erythematosus, and related conditions. In eukaryotic organisms the NE consists of five interconnected regions: an outer nuclear membrane (ONM) that is continuous with the endoplasmic reticulum, an ...
P, Enarson +5 more
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Nuclear pore complex ion channels (Review)
Molecular Membrane Biology, 1994It is currently thought that nuclear pore complexes (NPCs) primarily govern nucleocytoplasmic interactions via selective recognition and active transport of macromolecules. However, in various nuclear preparations, patch-clamp and fluorescence, luminiscence and ion microscopy support classical microelectrode measurements indicating that monoatomic ion ...
J O, Bustamante +2 more
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Cancer and the Nuclear Pore Complex
2014The nuclear pore complex (NPC) mediates trafficking between the cytoplasm and nucleoplasm. It also plays key roles in other nuclear processes such as chromatin silencing, transcriptional regulation, and DNA damage repair. Nucleoporins, the structural components of the NPC, have been linked to a multitude of cancers through chromosomal translocations ...
Dan N, Simon, Michael P, Rout
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Nuclear pores. Architecture of the nuclear pore complex coat.
Science (New York, N.Y.), 2015The nuclear pore complex (NPC) constitutes the sole gateway for bidirectional nucleocytoplasmic transport. Despite half a century of structural characterization, the architecture of the NPC remains unknown. Here we present the crystal structure of a reconstituted ~400-kilodalton coat nucleoporin complex (CNC) from Saccharomyces cerevisiae at a 7.4 ...
Tobias, Stuwe +6 more
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