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2010
Nuclear pore complexes (NPCs) are large macromolecular assemblies with an estimated mass of about 125 million Dalton. Depending on the activity of a cell, the number of NPCs varies but is usually around 3000–4000 per nucleus. NPCs are sites of bidirectional transport.
Margit Pavelka, Jürgen Roth
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Nuclear pore complexes (NPCs) are large macromolecular assemblies with an estimated mass of about 125 million Dalton. Depending on the activity of a cell, the number of NPCs varies but is usually around 3000–4000 per nucleus. NPCs are sites of bidirectional transport.
Margit Pavelka, Jürgen Roth
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The molecular architecture of the nuclear pore complex
Nature, 2007Nuclear pore complexes (NPCs) are proteinaceous assemblies of approximately 50 MDa that selectively transport cargoes across the nuclear envelope. To determine the molecular architecture of the yeast NPC, we collected a diverse set of biophysical and proteomic data, and developed a method for using these data to localize the NPC's 456 constituent ...
Alber, Frank +11 more
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Transcriptional regulation at the nuclear pore complex
Current Opinion in Genetics & Development, 2007The nonrandom spatial distribution of chromosomes and genes in the eukaryotic nucleus has been appreciated for decades, although a detailed understanding of the functional role of such positioning has remained illusive. The most prominent structural feature of the nucleus is the nuclear periphery, classically considered as a zone of gene repression ...
Christopher R, Brown, Pamela A, Silver
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Active genes at the nuclear pore complex
Current Opinion in Cell Biology, 2007The nucleus is spatially and functionally organized and its architecture is now seen as a key contributor to genome functions. A central component of this architecture is the nuclear envelope, which is studded with nuclear pore complexes that serve as gateways for communication between the nucleoplasm and cytoplasm.
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Nuclear export of pre-60S particles through the nuclear pore complex
Nature, 2023Sen-Fang Sui +2 more
exaly
Comprehensive structure and functional adaptations of the yeast nuclear pore complex
Cell, 2022Ilona Nudelman +2 more
exaly
The nuclear pore complex, nuclear transport, and apoptosis.
Canadian journal of physiology and pharmacology, 2006The nuclear pore complex (NPC) is the sole gateway between the nucleus and the cytoplasm of interphase eukaryotic cells, and it mediates all trafficking between these 2 cellular compartments. As such, the NPC and nuclear transport play central roles in translocating death signals from the cell membrane to the nucleus where they initiate biochemical and
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