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Functional Architecture of the Nuclear Pore Complex

Annual Review of Biophysics, 2012
The nuclear pore complex (NPC) is the sole gateway between the nucleus and the cytoplasm. NPCs fuse the inner and outer nuclear membranes to form aqueous translocation channels that allow the free diffusion of small molecules and ions, as well as receptor-mediated transport of large macromolecules.
Grossman, Einat   +2 more
openaire   +4 more sources

Structure and Assembly of the Nuclear Pore Complex

Annual Review of Biophysics, 2019
Nuclear pore complexes (NPCs) mediate nucleocytoplasmic exchange. They are exceptionally large protein complexes that fuse the inner and outer nuclear membranes to form channels across the nuclear envelope. About 30 different protein components, termed nucleoporins, assemble in multiple copies into an intricate cylindrical architecture.
Panagiotis L. Kastritis   +6 more
openaire   +3 more sources

Nuclear calcium and the regulation of the nuclear pore complex

BioEssays, 1997
AbstractIn eukaryotic cells the nucleus and its contents are separated from the cytoplasm by the nuclear envelope. Macromolecules, as well as smaller molecules and ions, can cross the nuclear envelope through the nuclear pore complex. Molecules greater than approx.
Carmen Perez-Terzic   +3 more
openaire   +3 more sources

The molecular architecture of the nuclear pore complex

Nature, 2007
Nuclear pore complexes (NPCs) are proteinaceous assemblies of approximately 50 MDa that selectively transport cargoes across the nuclear envelope. To determine the molecular architecture of the yeast NPC, we collected a diverse set of biophysical and proteomic data, and developed a method for using these data to localize the NPC's 456 constituent ...
Svetlana Dokudovskaya   +12 more
openaire   +3 more sources

Structure and Function of the Nuclear Pore Complex

Annual Review of Cell and Developmental Biology, 1992
INTRODUCTION 495 NUCLEAR TRANSPORT 496 An Overview 496 Structure of the Nuclear Pore Complex 498 Protein Import 500 Protein Export 508 RNA Export 509 RNA Import . . . . . . . . . . . . . . . . . . . . . . . .. ... . . . . . . .... .. .. 510 Genetic Approaches to RNA and Protein Transport 511 Control of Nuclear Transport ......... .......
openaire   +3 more sources

Radiation therapy‐associated toxicity: Etiology, management, and prevention

Ca-A Cancer Journal for Clinicians, 2021
Kyle Wang
exaly  

Magnetic resonance linear accelerator technology and adaptive radiation therapy: An overview for clinicians

Ca-A Cancer Journal for Clinicians, 2022
William A Hall   +2 more
exaly  

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