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Functional Architecture of the Nuclear Pore Complex
Annual Review of Biophysics, 2012The nuclear pore complex (NPC) is the sole gateway between the nucleus and the cytoplasm. NPCs fuse the inner and outer nuclear membranes to form aqueous translocation channels that allow the free diffusion of small molecules and ions, as well as receptor-mediated transport of large macromolecules.
Grossman, Einat +2 more
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Structure and Assembly of the Nuclear Pore Complex
Annual Review of Biophysics, 2019Nuclear pore complexes (NPCs) mediate nucleocytoplasmic exchange. They are exceptionally large protein complexes that fuse the inner and outer nuclear membranes to form channels across the nuclear envelope. About 30 different protein components, termed nucleoporins, assemble in multiple copies into an intricate cylindrical architecture.
Panagiotis L. Kastritis +6 more
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Nuclear calcium and the regulation of the nuclear pore complex
BioEssays, 1997AbstractIn eukaryotic cells the nucleus and its contents are separated from the cytoplasm by the nuclear envelope. Macromolecules, as well as smaller molecules and ions, can cross the nuclear envelope through the nuclear pore complex. Molecules greater than approx.
Carmen Perez-Terzic +3 more
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The molecular architecture of the nuclear pore complex
Nature, 2007Nuclear pore complexes (NPCs) are proteinaceous assemblies of approximately 50 MDa that selectively transport cargoes across the nuclear envelope. To determine the molecular architecture of the yeast NPC, we collected a diverse set of biophysical and proteomic data, and developed a method for using these data to localize the NPC's 456 constituent ...
Svetlana Dokudovskaya +12 more
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Structure and Function of the Nuclear Pore Complex
Annual Review of Cell and Developmental Biology, 1992INTRODUCTION 495 NUCLEAR TRANSPORT 496 An Overview 496 Structure of the Nuclear Pore Complex 498 Protein Import 500 Protein Export 508 RNA Export 509 RNA Import . . . . . . . . . . . . . . . . . . . . . . . .. ... . . . . . . .... .. .. 510 Genetic Approaches to RNA and Protein Transport 511 Control of Nuclear Transport ......... .......
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Radiation therapy‐associated toxicity: Etiology, management, and prevention
Ca-A Cancer Journal for Clinicians, 2021Kyle Wang
exaly