Results 161 to 170 of about 191,852 (331)

Reconstitution of nuclear envelope subdomain formation on mitotic chromosomes in semi-intact cells

Cell Structure and Function
In metazoans, the nuclear envelope (NE) disassembles during the prophase and reassembles around segregated chromatids during the telophase. The process of NE formation has been extensively studied using live-cell imaging.
Tomoko Funakoshi, Naoko Imamoto
doaj   +1 more source

Systematic Deletion and Mitotic Localization of the Nuclear Pore Complex Proteins of Aspergillus nidulans

, 2006
Aysha H. Osmani, Jonathan Davies, Huilin Liu, Aaron H. Nile, Stephen A. Osmani   +4 more
openalex   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Disrupted nuclear import of cell cycle proteins in Huntington's/PolyQ disease causes neurodevelopment defects in cellular and Drosophila model

Heliyon
Huntington's disease is caused by an expansion of CAG repeats in exon 1 of the huntingtin gene encoding an extended PolyQ tract within the Huntingtin protein (mHtt).
Sandeep Kumar Dubey, Thomas E. Lloyd, Madhu G. Tapadia   +2 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Nuclear Pore Complex Protein Nup93 [PDF]

, 2020
openaire   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Author response: Spatial structure of disordered proteins dictates conductance and selectivity in nuclear pore complex mimics

, 2018
Adithya N. Ananth, Ankur Mishra, Steffen Frey, Arvind Dwarkasing, Roderick Corstiaan Abraham Versloot, E. van der Giessen, Dirk Görlich, Patrick R. Onck, Cees Dekker   +8 more
openalex   +1 more source

GTP hydrolysis by Ran occurs at the nuclear pore complex in an early step of protein import. [PDF]

, 1995
Frauke Melchior, T Guan, Nobuhiko Yokoyama, T. Nishimoto, Larry Gerace   +4 more
openalex   +1 more source

You are who your friends are—nuclear pore proteins as components of chromatin‐binding complexes [PDF]

, 2023
Maya Capelson
openalex   +1 more source