Results 81 to 90 of about 191,852 (331)

Interplay of the nuclear envelope with chromatin in physiology and pathology

Nucleus, 2020
The nuclear envelope compartmentalizes chromatin in eukaryotic cells. The main nuclear envelope components are lamins that associate with a panoply of factors, including the LEM domain proteins.
Romina Burla, Mattia La Torre, Klizia Maccaroni, Fiammetta Verni, Simona Giunta, Isabella Saggio   +5 more
doaj   +1 more source

Regulation of anti-inflammatory gene expression in vascular endothelial cells by EPAC1 [PDF]

, 2015
Suppressor of cytokine signalling 3 (SOCS3) is a potent inhibitor of pro-inflammatory pathways involved in atherogenesis and the development of neo-intimal hyperplasia (NIH), which contributes to the in-stent re-stenosis responsible for the failure of ...
Palmer, Timothy P., Yarwood, Stephen J.
core   +1 more source

Nuclear Pore-Targeting Complex and Its Role on Nuclear Protein Transport.

Archives of Histology and Cytology, 1996
The process of selective nuclear protein transport is divided into at least two steps: 1) ATP-independent, nuclear localization signal (NLS)-dependent binding to the cytoplasmic face of nuclear pores and 2) ATP-dependent translocation through the nuclear pores.
openaire   +3 more sources

Quantitative Analysis of Membrane Protein Transport Across the Nuclear Pore Complex [PDF]

Traffic, 2013
Nuclear transport of the Saccharomyces cerevisiae membrane proteins Src1/Heh1 and Heh2 across the NPC is facilitated by a long intrinsically disordered linker between the nuclear localization signal (NLS) and the transmembrane domain. The import of reporter proteins derived from Heh2 is dependent on the FG‐Nups in the central channel, and the linker ...
Meinema, Anne C., Poolman, Bert, Veenhoff, Liesbeth M.   +2 more
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Viral Appropriation: Laying Claim to Host Nuclear Transport Machinery

Cells, 2019
Protein nuclear transport is an integral process to many cellular pathways and often plays a critical role during viral infection. To overcome the barrier presented by the nuclear membrane and gain access to the nucleus, virally encoded proteins have ...
Tanner M. Tessier, Mackenzie J. Dodge, Martin A. Prusinkiewicz, Joe S. Mymryk   +3 more
doaj   +1 more source

Importin-beta and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function [PDF]

, 2017
Protein conjugation with small ubiquitin-related modifier (SUMO) is a post-translational modification that modulates protein interactions and localisation.
Damizia, Michela, DE SANTIS, RICCARDO, DE TURRIS, VALERIA, GILISTRO, EUGENIA, Lavia, Patrizia, MORONI, SARA, ROSA, ALESSANDRO, VERRICO, ANNALISA   +7 more
core   +1 more source

Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy [PDF]

Journal of Clinical Investigation, 2016
The nuclear pore complex protein NUP88 is frequently elevated in aggressive human cancers and correlates with reduced patient survival; however, it is unclear whether and how NUP88 overexpression drives tumorigenesis. Here, we show that mice overexpressing NUP88 are cancer prone and form intestinal tumors.
Naylor, R.M., Jeganathan, K.B., Cao, X., Deursen, J.M.A. van   +3 more
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Nuclear pore complex protein RANBP2 and related SUMOylation in solid malignancies

Genes & Diseases
The growing interest in post-translational protein modification, particularly in SUMOylation, is driven by its crucial role in cell cycle regulation. SUMOylation affects various cell cycle regulators, including oncogenes, suggesting its relevance in cancer.
Xinning Yu, Huatao Wu, Zhenhua Wu, Yangzheng Lan, Wen-Jia Chen, Bingxuan Wu, Yu Deng, Jing Liu   +7 more
openalex   +4 more sources