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British Journal of Pharmacology, 2007 ALEXANDER, S.P.H., MATHIE, A. & PETERS, J.A. (2007). Guide to Receptors and Channels (GRAC), 2nd edition (2007 revision). Br. J. Pharmacol., 150 (Suppl. 1), S1–S168.
John A. Peters +2 more
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The nuclear receptor superfamily [PDF]
Journal of Cell Science, 2003 Nuclear receptors are one of the most abundant classes of transcriptional regulators in animals (metazoans). They regulate diverse functions, such as homeostasis, reproduction, development and metabolism (for a review, see [Laudet and Gronemeyer, 2002][1]).
Robinson-Rechavi, M. +2 more
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Signaling by Nuclear Receptors [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Nuclear receptors are activated by lipid-soluble signals (e.g., steroid hormones) that cross the plasma membrane. Once activated, most function as transcription factors to control gene expression for numerous biological processes.
Christopher K. Glass, Richard Sever
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Nuclear receptors in osteoclasts
Current Opinion in Pharmacology, 2020 Osteoclasts are bone-resorbing cells that play an essential role in the remodeling of bone under physiological conditions and numerous pathological conditions, such as osteoporosis, bone metastasis, and inflammatory bone erosion. Nuclear receptors are crucial to various physiological processes, including metabolism, development and inflammation, and ...
Kyung-Hyun Park-Min +2 more
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Dynamics of Nuclear Receptors [PDF]
Structure, 2010 The dynamic properties of VDR LBD and full-length VDR/RXRα heterodimer in the presence and absence of ligands were investigated by hydrogen/deuterium exchange mass spectrometry (Zhang et al., 2010a). The results beautifully complement X-ray crystal structure data.
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Endometriosis and nuclear receptors [PDF]
Human Reproduction Update, 2019 Abstract BACKGROUND Endometriosis is recognized as a steroid-dependent disorder; however, the precise roles of nuclear receptors (NRs) in steroid responsiveness and other signaling pathways are not well understood. OBJECTIVE AND RATIONALE
Bahar D Yilmaz, Serdar E Bulun
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Nuclear receptor corepressors [PDF]
Nuclear Receptor Signaling, 2003 The ability of NR LBDs to transfer repression function to a heterologous DNA binding domain, and the cross-squelching of repression by untethered LBDs, has suggested that repression is mediated by interactions with putative cellular corepressor proteins.
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The Orphan Nuclear Receptor TR4 Is a Vitamin A-activated Nuclear Receptor [PDF]
Journal of Biological Chemistry, 2011 Testicular receptors 2 and 4 (TR2/4) constitute a subgroup of orphan nuclear receptors that play important roles in spermatogenesis, lipid and lipoprotein regulation, and the development of the central nervous system. Currently, little is known about the structural features and the ligand regulation of these receptors.
Yong Xu +9 more
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The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis [PDF]
Human Reproduction Update, 2014 Endometriosis is defined as the colonization and growth of endometrial tissue at anatomic sites outside the uterine cavity. Up to 15% of reproductive-aged women in the USA suffer from painful symptoms of endometriosis, such as infertility, pelvic pain, menstrual cycle abnormalities and increased risk of certain cancers.
Sang Jun Han, Bert W. O'Malley
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Nuclear Receptor Signaling: A Home for Nuclear Receptor and Coregulator Signaling Research [PDF]
Nuclear Receptor Signaling, 2014 The field of nuclear receptor and coregulator signaling has grown into one of the most active and interdisciplinary in eukaryotic biology. Papers in this field are spread widely across a vast number of journals, which complicates the task of investigators in keeping current with the literature in the field.
Neil J. McKenna +2 more
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