Results 151 to 160 of about 734,603 (316)

Liver‐specific lncRNAs associated with liver cancers

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina, Roman K. Makarchenko, Maria P. Rubtsova, Olga A. Dontsova   +3 more
wiley   +1 more source

Orphan nuclear receptor transcription factors as drug targets. [PDF]

Transcription
Safe S, Oany AR, Tsui WN, Lee M, Srivastava V, Upadhyay S, Hailemariam A, Farkas E, Kakwan S, Kearns C, Sivaram G.   +10 more
europepmc   +1 more source

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

Nuclear Receptor ERRγ Protects Against Cardiac Ischemic Injury by Suppressing GBP5-Mediated Myocardial Inflammation. [PDF]

FASEB J
Qiu J, Che Q, Zhang Y, Chen M, Wei Z, Bai Y, Zhao T, Yan J, Wu Z, Fei Z, Wang Y, Wang Q, Li YG.   +12 more
europepmc   +1 more source

In situ cross-linking of androgen receptors to nuclear acceptor sites of rat prostate with formaldehyde.

, 1985
John A. Foekens, Paul S. Rennie, H.W. Cheng, Nicholas Bruchovsky   +3 more
openalex   +1 more source

Evolution of the nuclear receptor gene superfamily. [PDF]

, 1992
Vincent Laudet, Catherine Hänni, Jean Coll, François Catzeflis, D. Stéhelin   +4 more
openalex   +1 more source

Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3

FEBS Open Bio, EarlyView.
PAX5::CBFA2T3 (PAX5‐C) is a fusion protein of the B‐cell transcription factor, PAX5, and is found in B‐cell ALL. We propose a putative model of two‐way inhibition of PAX5 transcriptional activity by PAX5‐C. There are two ways of repression by PAX5‐C: DNA‐binding‐dependent way and HDAC‐dependent way, with either being sufficient for the repression. HDAC
Reina Ueno, Aki Terasaki, Yuiko Imai, Yuri Kimura, Yuna Kojima, Misa Irie, Koya Odaira, Mina Noura, Shuichi Okamoto, Takahiko Yasuda, Shinobu Tsuzuki, Hitoshi Kiyoi, Fumihiko Hayakawa   +12 more
wiley   +1 more source

Editorial: Nuclear Receptors and Coregulators in Metabolism and Immunity

Frontiers in Endocrinology, 2021
Rongrong Fan, Ines Pineda-Torra, Nicolas Venteclef   +2 more
doaj   +1 more source

A long journey to the discovery of nuclear receptor coactivator existence, physiology, pathology, and therapy. [PDF]

J Biol Chem
O'Malley BW.
europepmc   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source