Results 11 to 20 of about 804,673 (258)

Compound A influences gene regulation of the Dexamethasone-activated glucocorticoid receptor by alternative cofactor recruitment

Scientific Reports, 2017
The glucocorticoid receptor (GR) is a transcription factor of which the underlying gene regulatory mechanisms are complex and incompletely understood. The non-steroidal anti-inflammatory Compound A (CpdA), a selective GR modulating compound in various ...
S. J. Desmet, N. Bougarne, L. Van Moortel, L. De Cauwer, J. Thommis, M. Vuylsteke, D. Ratman, R. Houtman, J. Tavernier, K. De Bosscher   +9 more
doaj   +1 more source

Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor

Journal of Lipid Research, 2002
The nuclear pregnane X receptor (PXR; NR1I2) is an integral component of the body's defense mechanism against chemical insult (chemoprotection). PXR is activated by a diverse array of lipophilic chemicals, including xenobiotics and endogenous substances,
Steven A. Kliewer, Timothy M. Willson
doaj   +1 more source

Improved Glucocorticoid Receptor Ligands: Fantastic Beasts, but How to Find Them?

Frontiers in Endocrinology, 2020
Exogenous glucocorticoids are widely used in the clinic for the treatment of inflammatory disorders and hematological cancers. Unfortunately, their use is associated with debilitating side effects, including hyperglycemia, osteoporosis, mood swings, and ...
Laura Van Moortel, Laura Van Moortel, Laura Van Moortel, Kris Gevaert, Kris Gevaert, Karolien De Bosscher, Karolien De Bosscher, Karolien De Bosscher   +7 more
doaj   +1 more source

Nuclear receptor corepressors [PDF]

Nuclear Receptor Signaling, 2003
The ability of NR LBDs to transfer repression function to a heterologous DNA binding domain, and the cross-squelching of repression by untethered LBDs, has suggested that repression is mediated by interactions with putative cellular corepressor proteins.
openaire   +2 more sources

Mechanisms Underlying the Functional Cooperation Between PPARα and GRα to Attenuate Inflammatory Responses

Frontiers in Immunology, 2019
Glucocorticoids (GCs) act via the glucocorticoid receptor (NR3C1, GRα) to combat overshooting responses to infectious stimuli, including lipopolysaccharide (LPS).
Nadia Bougarne, Nadia Bougarne, Nadia Bougarne, Viacheslav Mylka, Viacheslav Mylka, Viacheslav Mylka, Dariusz Ratman, Dariusz Ratman, Dariusz Ratman, Ilse M. Beck, Jonathan Thommis, Jonathan Thommis, Jonathan Thommis, Lode De Cauwer, Lode De Cauwer, Lode De Cauwer, Jan Tavernier, Jan Tavernier, Jan Tavernier, Bart Staels, Claude Libert, Claude Libert, Karolien De Bosscher, Karolien De Bosscher, Karolien De Bosscher   +24 more
doaj   +1 more source

SnapShot: Nuclear Receptors I

Cell, 2010
Clinical: Flutamide and bicalutamide for prostate cancer and alopeciaGlucocorticoid receptorGR/NR3C1 Endogenous: Cortisol (hydrocortisone) Diverse developmental and physiological roles (e.g., antagonism of inflammatory signaling pathways, mediation of the stress response, and gluconeogenesis)Metabolic, cardiovascular, immune and inflammatory, memory↑
McKenna, Neil J., O'Malley, Bert W.
openaire   +3 more sources

Transcriptional Profiling of Monocytes Deficient in Nuclear Orphan Receptors NR4A2 and NR4A3 Reveals Distinct Signalling Roles Related to Antigen Presentation and Viral Response

Frontiers in Immunology, 2021
The nuclear receptor sub-family 4 group A (NR4A) family are early response genes that encode proteins that are activated in several tissues/cells in response to a variety of stressors.
David E. Phelan, David E. Phelan, Masahiko Shigemura, Sarah Aldhafiri, Sarah Aldhafiri, Catarina Mota, Catarina Mota, Thomas J. Hall, Jacob I. Sznajder, Evelyn P. Murphy, Daniel Crean, Daniel Crean, Eoin P. Cummins, Eoin P. Cummins   +13 more
doaj   +1 more source

A FAIR-Based Approach to Enhancing the Discovery and Re-Use of Transcriptomic Data Assets for Nuclear Receptor Signaling Pathways

Data Science Journal, 2017
Public transcriptomic assets in the nuclear receptor (NR) signaling field hold considerable collective potential for exposing underappreciated aspects of NR regulation of gene expression.
Scott A. Ochsner, Yolanda F. Darlington, Apollo McOwiti, Wasula H. Kankanamge, Alexey Naumov, Lauren B. Becnel, Neil J. McKenna   +6 more
doaj   +1 more source

Plasmodium berghei NK65 in Combination with IFN-γ Induces Endothelial Glucocorticoid Resistance via Sustained Activation of p38 and JNK

Frontiers in Immunology, 2017
Malaria-associated acute respiratory distress syndrome (MA-ARDS) is an often lethal complication of malaria. Currently, no adequate therapy for this syndrome exists. Although glucocorticoids (GCs) have been used to improve clinical outcome of ARDS, their
Karolina A. Zielińska, Lode de Cauwer, Sofie Knoops, Kristof Van der Molen, Alexander Sneyers, Jonathan Thommis, J. Brian De Souza, Ghislain Opdenakker, Karolien De Bosscher, Philippe E. Van den Steen   +9 more
doaj   +1 more source

Full-length nuclear receptor allosteric regulation

Journal of Lipid Research, 2023
Nuclear receptors are a superfamily of transcription factors regulated by a wide range of lipids that include phospholipids, fatty acids, heme-based metabolites, and cholesterol-based steroids. Encoded as classic two-domain modular transcription factors,
Woong Jae Choi, Zeinab Haratipour, Raymond D. Blind   +2 more
doaj   +1 more source