Results 71 to 80 of about 548,108 (301)

Importins involved in the nuclear transportation of steroid hormone receptors: In silico and in vitro data

Frontiers in Endocrinology, 2022
The nuclear receptor superfamily (NRS) consists of 48 receptors for lipophilic substances and is divided into 7 different subfamilies, with subfamily 3 comprising steroid hormone receptors.
Konstantina Kalyvianaki, Athanasios A. Panagiotopoulos, Maria Patentalaki, Elias Castanas, Marilena Kampa   +4 more
doaj   +1 more source

Nuclear Receptor Corepressors and PPARγ [PDF]

Nuclear Receptor Signaling, 2006
The nuclear receptor corepressors NCoR and SMRT repress gene transcription by recruiting a histone deacetylase complex. Their roles in PPARγ action have been controversial. Recent evidence, however, suggests that NCoR and SMRT repress PPARγ-mediated transcriptional activity on specific promoters in the adipocyte.
openaire   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Therapeutic potential of nuclear receptor agonists in Alzheimer's disease

Journal of Lipid Research, 2017
Alzheimer's disease (AD) is characterized by an extensive accumulation of amyloid-β (Aβ) peptide, which triggers a set of deleterious processes, including synaptic dysfunction, inflammation, and neuronal injury, leading to neuronal loss and cognitive ...
Miguel Moutinho, Gary E. Landreth
doaj   +1 more source

Molecular Dynamics: a tool to understand nuclear receptors

, 2012
Nuclear receptors (NRs) are evolutionary conserved proteins whose encoding genes are expressed in the animal kingdom. The wide family of NRs counts more than 150 members, represented by both steroidal and non-steroidal receptors and by a multitude of ...
X. Barril, SPYRAKIS, Francesca, F. Javier Luque*, Francesca Spyrakis*, Xavier Barril*, F. J. Luque   +5 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Expression of Tas1 taste receptors in mammalian spermatozoa [PDF]

, 2012
Background: During their transit through the female genital tract, sperm have to recognize and discriminate numerous chemical compounds. However, our current knowledge of the molecular identity of appropriate chemosensory receptor proteins in sperm is ...
Ulrich Boehm (180339), de Angelis Martin Hrabé, Breit, A., Dorke Meyer, Andreas Breit (180329), Hrabě de Angelis, M., Widmayer Patricia, Wolfgang Meyerhof, Boekhoff Ingrid, Boehm, Ulrich, Martin Hrabé de Angelis, Meyer, Dorke, Ulrich Boehm, Dorke Meyer (180311), Sandra Huebner, Gudermann, T., Boehm, U., Borth, Heike, Borth Heike, Meyerhof, Wolfgang, Susan Marschall, Huebner Sandra, Voigt, Anja, Meyerhof, W., Hrabé de Angelis, Martin, Huebner, S., Sandra Huebner (180323), Thomas Gudermann (77426), Huebner, Sandra, Heike Borth, Borth, H., Susan Marschall (180334), Meyerhof Wolfgang, Ingrid Boekhoff, Ingrid Boekhoff (180345), Heike Borth (180317), Andreas Breit, Meyer Dorke, Boekhoff, I., Voigt Anja, Thomas Gudermann, Anja Voigt, Voigt, A., Gudermann Thomas, Breit Andreas, Boehm Ulrich, Marschall Susan, Marschall, Susan, Widmayer, Patricia, Widmayer, P., Wolfgang Meyerhof (7851), Patricia Widmayer, Martin Hrabé de Angelis (10007), Patricia Widmayer (180314), Breit, Andreas, Boekhoff, Ingrid, Gudermann, Thomas, Anja Voigt (173059), Marschall, S., Meyer, D.   +59 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source