Results 31 to 40 of about 6,071,343 (411)

Active RNAP pre-initiation sites are highly mutated by cytidine deaminases in yeast, with AID targeting small RNA genes

eLife, 2014
Cytidine deaminases are single stranded DNA mutators diversifying antibodies and restricting viral infection. Improper access to the genome leads to translocations and mutations in B cells and contributes to the mutation landscape in cancer, such as ...
Benjamin JM Taylor, Yee Ling Wu, Cristina Rada   +2 more
doaj   +1 more source

Comprehensive analysis reveals a 5-gene signature and immune cell infiltration in Alzheimer’s disease with qPCR validation

Frontiers in Genetics, 2022
Over 50 million people around the world currently are suffering from Alzheimer’s disease (AD) without any effective therapy. Neuroinflammation plays a pivotal role in AD, which leads us to probe the profile of immune cell infiltration in AD.
Fanmao Jin, Yuemei Xi, Yuemei Xi, De Xie, De Xie, Qiang Wang, Qiang Wang   +6 more
doaj   +1 more source

Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]

, 2011
Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Troiber, Christina, Wagner, Ernst
core   +1 more source

Investigating the mechanism of action of hemofugal and blood-stasis-expelling soup in the treatment of coronary heart disease based on network pharmacology [PDF]

BIO Web of Conferences
Objective: To investigate the mechanism of action of Xuefu yuyuxu Tang in the treatment of Coronary Heart Disease (CHD) based on network-based pharmacology.
·yusuf Arslan, Ma Yun, Wang Qi
doaj   +1 more source

Receptor of Advanced Glycation End Products Deficiency Attenuates Cisplatin-Induced Acute Nephrotoxicity by Inhibiting Apoptosis, Inflammation and Restoring Fatty Acid Oxidation

Frontiers in Pharmacology, 2022
Cisplatin is a widely used and potent anti-neoplastic agent, but severe and inescapable side effects in multiple normal tissues and organs limit its application, especially nephrotoxicity.
Qiang Wang, Qiang Wang, Yuemei Xi, Yuemei Xi, Binyang Chen, Binyang Chen, Hairong Zhao, Hairong Zhao, Wei Yu, Wei Yu, De Xie, De Xie, Weidong Liu, Weidong Liu, Furong He, Furong He, Chenxi Xu, Chenxi Xu, Jidong Cheng, Jidong Cheng   +19 more
doaj   +1 more source

A Theoretical Mechanism of Szilard Engine Function in Nucleic Acids and the Implications for Quantum Coherence in Biological Systems [PDF]

AIP Conf. Proc. 1316, July 2010, pp. 287-290, 2012
Nucleic acids theoretically possess a Szilard engine function that can convert the energy associated with the Shannon entropy of molecules for which they have coded recognition, into the useful work of geometric reconfiguration of the nucleic acid molecule.
arxiv   +1 more source

Ab Initio Nucleic Acid Folding Simulations Using a Physics-Based Atomistic Free Energy Model [PDF]

, 2022
Performing full-resolution atomistic simulations of nucleic acid folding has remained a challenge for biomolecular modeling. Understanding how nucleic acids fold and how they transition between different folded structures as they unfold and refold has important implications for biology.
arxiv   +1 more source

Helicase processivity and not the unwinding velocity exhibits universal increase with force [PDF]

, 2015
Helicases, involved in a number of cellular functions, are motors that translocate along singlestranded nucleic acid and couple the motion to unwinding double-strands of a duplex nucleic acid.
Chakrabarti, Shaon, Pincus, David L., Thirumalai, D.   +2 more
core   +2 more sources

Nucleic acid memory [PDF]

Nature Materials, 2016
Nucleic acid memory has a retention time far exceeding electronic memory. As an alternative storage media, DNA surpasses the information density and energy of operation offered by flash memory.
Zhirnov, Victor, Zadegan, Reza M., Sandhu, Gurtej S., Church, George M., Hughes, William L.   +4 more
openaire   +4 more sources

Responsive Nucleic Acid-Based Organosilica Nanoparticles [PDF]

, 2023
The development of smart nanoparticles (NPs) that encode responsive features in the structural framework promises to extend the applications of NP-based drugs, vaccines, and diagnostic tools.
Bertucci, A, Biedermann, F, Corradini, R, De Cola, L, Dore, MD, Neri, M, Picchetti, P, Porchetta, A, Rossetti, M, Sleiman, H, Trinh, T, Volpi, S   +11 more
core   +1 more source