Results 31 to 40 of about 6,135,044 (385)

Mfold web server for nucleic acid folding and hybridization prediction

Nucleic Acids Res., 2003
The abbreviated name, 'mfold web server', describes a number of closely related software applications available on the World Wide Web (WWW) for the prediction of the secondary structure of single stranded nucleic acids.
M. Zuker
semanticscholar   +1 more source

Overcoming the bottleneck to widespread testing: a rapid review of nucleic acid testing approaches for COVID-19 detection

RNA: A publication of the RNA Society, 2020
The current COVID-19 pandemic presents a serious public health crisis, and a better understanding of the scope and spread of the virus would be aided by more widespread testing.
Meagan N. Esbin, O. Whitney, Shasha Chong, Anna C. Maurer, X. Darzacq, R. Tjian   +5 more
semanticscholar   +1 more source

A Guide to Nucleic Acid Vaccines in the Prevention and Treatment of Infectious Diseases and Cancers: From Basic Principles to Current Applications

Frontiers in Cell and Developmental Biology, 2021
Faced with the challenges posed by infectious diseases and cancer, nucleic acid vaccines present excellent prospects in clinical applications. Compared with traditional vaccines, nucleic acid vaccines have the characteristics of high efficiency and low ...
Furong Qin, Fan Xia, Hong-li Chen, Bomiao Cui, Yun Feng, Ping Zhang, Jiao Chen, Min Luo   +7 more
semanticscholar   +1 more source

Modeling nucleic acids [PDF]

Current Opinion in Structural Biology, 2012
Nucleic acids are an important class of biological macromolecules that carry out a variety of cellular roles. For many functions, naturally occurring DNA and RNA molecules need to fold into precise three-dimensional structures. Due to their self-assembling characteristics, nucleic acids have also been widely studied in the field of nanotechnology, and ...
Sim, A, Minary, P, Levitt, M
openaire   +4 more sources

Experimental exploration of a ribozyme neutral network using evolutionary algorithm and deep learning

Nature Communications, 2022
Neutral networks, which are sets of genotypes connected via single mutations that share the same phenotype, are important for evolvability. Here, the authors provide experimental evidence of a neutral network in an RNA enzyme using a high-throughput ...
Rachapun Rotrattanadumrong, Yohei Yokobayashi   +1 more
doaj   +1 more source

Massively multiplexed nucleic acid detection with Cas13

Nature, 2020
The great majority of globally circulating pathogens go undetected, undermining patient care and hindering outbreak preparedness and response. To enable routine surveillance and comprehensive diagnostic applications, there is a need for detection ...
Cheri M Ackerman, C. Myhrvold, Sri Gowtham Thakku, C. A. Freije, Hayden C. Metsky, David K. Yang, Simon H. Ye, C. Boehm, Tinna-Sólveig F. Kosoko-Thoroddsen, Jared Kehe, Tien G. Nguyen, Amber Carter, Anthony B. Kulesa, J. Barnes, V. Dugan, D. Hung, P. Blainey, Pardis C Sabeti   +17 more
semanticscholar   +1 more source

Nucleic Acids Analysis [PDF]

Science China Chemistry, 2020
Nucleic acids are natural biopolymers of nucleotides that store, encode, transmit and express genetic information, which play central roles in diverse cellular events and diseases in living things. The analysis of nucleic acids and nucleic acids-based analysis have been widely applied in biological studies, clinical diagnosis, environmental analysis ...
Zai-Sheng Wu, Juewen Liu, Hua Kuang, Chao Zhang, Lihua Wang, Chaoyong Yang, Chaoyong Yang, Da Han, Changlong Hao, Qian Li, Min Li, Libing Liu, Fang Luo, Jianbin Wang, Jiang Li, Chunhai Fan, Xiaolei Zuo, Fujian Huang, Yan-Ru Chen, Huanghao Yang, Lingling Wu, Zhi Zhu, Bo Tang, Zhenyu Lin, Jiashu Sun, Xiuhai Mao, Dingbin Liu, Bi-Feng Yuan, Shu Wang, Fei Wang, Chun-Hua Lu, Yanyi Huang, Jinqi Deng, Xiaoguo Liu, Guoliang Ke, Fan Xia, Quan Yuan, Na Li, Xiao-Bing Zhang, Yongxi Zhao, Feng Chen, Fan Li, Weihong Tan, Weihong Tan, Yang Yang, Chuanlai Xu   +45 more
openaire   +2 more sources

Nanostructured luminescently labeled nucleic acids [PDF]

, 2017
Important and emerging trends at the interface of luminescence, nucleic acids and nanotechnology are: (i) the conventional luminescence labeling of nucleic acid nanostructures (e.g. DNA tetrahedron); (ii) the labeling of bulk nucleic acids (e.g. single‐
Adleman, Ai, Beater, Bi, Branton, Cao, Casini, Chen, Corstjens, Deng, Ding, Ding, Ding, Divsar, Du, Duan, Dunn, ENCODE, Fortina, Fortina, Gerling, Gommers-Ampt, Goodman, Han, He, He, He, He, He, Hembury, Heuer-Jungemann, Horikoshi, Hu, Huang, Jia, Ke, Kim, Knoblauch, Kricka, Kricka, Kwok, Lee, Li, Li, Lin, Liu, Liu, Liu, Lu, Ma, Maden, Mouse ENCODE Consortium, Nangreave, Nirenberg, Obliosca, Orbach, Ozhalici-Unal, Park, Park, Parker, Petty, Pinehiro, Randeria, Ren, Richards, Rijke, Ritchie, Rotaru, Rothemund, Seeman, Seferos, Severcan, Sharma, Shchepinov, Shen, Simonetti, Stahl, Stolper, Taton, Vanyushin, Vasudevan, Vummidi, Wang, Wang, Wang, Wang, Wang, Wang, Wu, Wu, Yan, Yang, Yang, Yang, Ye, Yeh, Yu, Yuan, Yurke, Zhang, Zhang, Zhang, Zhang, Zhao, Zheng, Zhou   +105 more
core   +1 more source

False negative of RT‐PCR and prolonged nucleic acid conversion in COVID‐19: Rather than recurrence

Journal of Medical Virology, 2020
A novel coronavirus (COVID-19) pandemic cause by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) threatens the world. We read with interest the recent report by Li et al.
Ai Tang Xiao, Y. Tong, S. Zhang
semanticscholar   +1 more source

An ultrasensitive photoelectrochemical nucleic acid biosensor [PDF]

, 2005
A simple and ultrasensitive procedure for non-labeling detection of nucleic acids is described in this study. It is based on the photoelectrochemical detection of target nucleic acids by forming a nucleic acid/photoreporter adduct layer on an ITO ...
Gao, Zhiqiang, Tansil, Natalia C.
core   +3 more sources