Results 41 to 50 of about 187,051 (303)
Clinical application of high throughput molecular screening techniques for pharmacogenomics. [PDF]
, 2011 Genetic analysis is one of the fastest-growing areas of clinical diagnostics. Fortunately, as our knowledge of clinically relevant genetic variants rapidly expands, so does our ability to detect these variants in patient samples.
Schrijver, Iris, Wiita, Arun P
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Biosensors, 2023 Nucleic acid detection is widely used to identify infectious diseases and ensure food safety. However, conventional PCR-based techniques are time consuming.
Weidong Wu +3 more
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Liquid biopsy genotyping in lung cancer: ready for clinical utility? [PDF]
, 2017 Liquid biopsy is a blood test that detects evidence of cancer cells or tumor DNA in the circulation. Despite complicated collection methods and the requirement for technique-dependent platforms, it has generated substantial interest due, in part, to its ...
Chen, Yi-Lin +7 more
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The cost effectiveness of Nucleic Acid Amplification Techniques for the diagnosis of tuberculosis [PDF]
Respiratory Medicine, 2012 There is wide variation in the techniques deployed to diagnose tuberculosis in the UK, with little agreement on which tools or strategies are cost effective. This analysis therefore comprehensively evaluated the cost effectiveness of currently available diagnostic strategies for routine diagnosis of TB in the NHS.The analysis compared strategies ...
Hughes, Ralph +3 more
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A comparison of nucleic acid amplification techniques for the assessment of bacterial viability [PDF]
Letters in Applied Microbiology, 2001 The ability to determine the presence and viability status of bacteria by molecular methods could offer significant advantages to the food, environmental and health sectors, in terms of improved speed and sensitivity of detection.In this study, we have assessed three amplification techniques, PCR, RT-PCR and NASBA, for their ability to detect nucleic ...
L, Birch +3 more
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Novel approaches toward preferential detection of viable cells using nucleic acid amplification techniques [PDF]
FEMS Microbiology Letters, 2009 This article elaborates on possible future directions for microbial viability assessment using nucleic acid-modifying compounds in combination with DNA- (and potentially RNA-) amplification technologies. Bacteria were traditionally considered viable when they could be cultured, whereas today's viability concept is based on the presence of some form of ...
Andreas, Nocker, Anne K, Camper
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Biosensors and Bioelectronics: X, 2023 The recent emergence of human coronaviruses (CoVs) causing severe acute respiratory syndrome (SARS) is posing a great threat to global public health. Therefore, the rapid and accurate identification of pathogenic viruses plays a vital role in selecting ...
Xucheng Huang +4 more
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Aptamer-based therapeutics and their potential in radiopharmaceutical design [PDF]
, 2007 Aptamers, short, single stranded oligonucleotide entities, have been developed in the past 15 years against a plethora of targets and for a variety of applications.
Ferreira, Catia S. M. +1 more
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FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
The impact of molecular biology on assessment of water quality: advantages and limitations of current techniques [PDF]
, 1997 The advent of molecular biology has had a dramatic impact on all aspects of biology, not least applied microbial ecology. Microbiological testing of water has traditionally depended largely on culture techniques.
Saunders, J.R., Saunders, V.A.
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