Secondary structure formation of homopolymeric single-stranded nucleic acids including force and loop entropy: implications for DNA hybridization [PDF]
arXiv, 2011 Loops are essential secondary structure elements in folded DNA and RNA molecules and proliferate close to the melting transition. Using a theory for nucleic acid secondary structures that accounts for the logarithmic entropy c ln m for a loop of length m, we study homopolymeric single-stranded nucleic acid chains under external force and varying ...
Einert, Thomas R. +2 more
arxiv +3 more sources
Theory for RNA folding, stretching, and melting including loops and salt [PDF]
, 2011 Secondary structure formation of nucleic acids strongly depends on salt concentration and temperature. We develop a theory for RNA folding that correctly accounts for sequence effects, the entropic contributions associated with loop formation, and salt effects.
Einert, Thomas R., Netz, Roland R.
arxiv +4 more sources
Base composition of DNA in adenovirus-12-induced tumor [PDF]
, 1969 A series of experiments was conducted to study the base composition of DNA in AVl2-induced tumor and host cells by paper chromatography, and it was found that DNA per cent. guanine-cystosine contents were around 42 % in both of them. The base composition
Ohmori, Masaki
core +1 more source
Rapid Optical Cavity PCR. [PDF]
, 2015 Recent outbreaks of deadly infectious diseases, such as Ebola and Middle East respiratory syndrome coronavirus, have motivated the research for accurate, rapid diagnostics that can be administered at the point of care.
Gustafson, Lars +6 more
core +2 more sources
Design, synthesis, conformational analysis and nucleic acid hybridisation properties of thymidyl pyrrolidine-amide oligonucleotide mimics (POM) [PDF]
, 2003 Pyrrolidine-amide oligonucleotide mimics (POM) 1 were designed to be stereochemically and conformationally similar to natural nucleic acids, but with an oppositely charged, cationic backbone.
Cooper, M.A. +5 more
core +1 more source
Accurate quantification of nucleic acids using hypochromicity measurements in conjunction with UV spectrophotometry [PDF]
, 2017 UV absorbance spectrophotometry is widely used for the quantification of nucleic acids. For accurate quantification it is important to determine the hypochromocity of the oligonucleotide or complex nucleic acid structure.
Dickman, M.J. +3 more
core +1 more source
Urea-induced denaturation of PreQ1-riboswitch [PDF]
J. Am. Chem. Soc. 2013, 2013 Urea, a polar molecule with a large dipole moment, not only destabilizes the folded RNA structures, but can also enhance the folding rates of large ribozymes. Unlike the mechanism of urea-induced unfolding of proteins, which is well understood, the action of urea on RNA has barely been explored.
arxiv +1 more source
Free energy landscape and characteristic forces for the initiation of DNA unzipping [PDF]
, 2015 DNA unzipping, the separation of its double helix into single strands, is crucial in modulating a host of genetic processes. Although the large-scale separation of double-stranded DNA has been studied with a variety of theoretical and experimental ...
Andricioaei, Ioan +5 more
core +2 more sources
Observation of coherent delocalized phonon-like modes in DNA under physiological conditions [PDF]
, 2016 Underdamped terahertz-frequency delocalized phonon-like modes have long been suggested to play a role in the biological function of DNA. Such phonon modes involve the collective motion of many atoms and are prerequisite to understanding the molecular ...
Ellis, Elizabeth M. +6 more
core +1 more source
Stability of nucleic acid bases in concentrated sulfuric acid: Implications for the habitability of Venus' clouds [PDF]
PNAS, June 12, 2023, 120 (25) e2220007120, 2023 What constitutes a habitable planet is a frontier to be explored and requires pushing the boundaries of our terracentric viewpoint for what we deem to be a habitable environment. Despite Venus' 700 K surface temperature being too hot for any plausible solvent and most organic covalent chemistry, Venus' cloud-filled atmosphere layers at 48 to 60 km ...
arxiv +1 more source